Tinospora tuberculata Suppresses Nitric Oxide Synthesis in Mouse Macrophages
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概要
- 論文の詳細を見る
We have obtained evidence that co-incubation of thioglycollate-elicited peritoneal macrophages with an aqueous extract of Tinospora tuberculata inhibits lipopolysaccharide-stimulated excessive production of nitric oxide (NO) in vitro. This effect is concentration-dependent and appears to involve suppression of both inducible nitric oxide synthase (iNOS) activity and NADPH-diaphorase activity, thus altering NO production. As NO is one of the critical mediators in various disorders and iNOS inhibitors may have therapeutic potential, these results may explain some aspects of the multifunctional properties of Tinospora tuberculata, which has been used in various folk remedies in southeast Asia and China.
- 公益社団法人日本薬学会の論文
- 1999-12-15
著者
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Yokozawa Takako
Institute of Natural Medicine, University of Toyama
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横澤 隆子
富山医科薬科大学和漢薬研究所
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HATTORI Masao
Institute of Natural Medicine, University of Toyama
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Chen C
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Yokozawa Takako
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Hattori Masao
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Hattori M
Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University
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Hattori M
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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CHEN Cui
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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WANG Tian
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Chen Cui
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Wang Tian
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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横澤 隆子
Inst. Of Natural Medicine Univ. Of Toyama
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Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
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