Identification of Antidiabetic Effect of Iridoid Glycosides and Low Molecular Weight Polyphenol Fractions of Corni Fructus, a Constituent of Hachimi-jio-gan, in Streptozotocin-Induced Diabetic Rats

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概要

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• In our previous study, Corni Fructus (Cornus officinalis SIEB. et ZUCC.), a component crude drug of the Chinese prescription Hachimi-jio-gan, was reported to reduce glucotoxicities, up-regulate renal function, and consequently ameliorate glycation-associated renal damage as well as Hachimi-jio-gan. Based upon these facts, we prepared Corni Fructus fractions and evaluated which fraction contained the effective components against diabetes, using one iridoid glycoside and three polyphenol fractions, which were expected to possess stronger activities than Corni Fructus, administered orally at a dose of 20 mg/kg body weight/d for 10 d, respectively. As a result, iridoid glycosides and low molecular weight polyphenol fractions could reduce the pathogenesis of diabetic renal damage, each having different mechanisms, i.e., iridoid glycosides successfully decreased the hyperglycemic state and affected renal advanced glycation end-product (AGE) accumulation, such as Nε-(carboxyethyl)lysine and Nε-(carboxymethyl)lysine, while low molecular weight polyphenol fractions could reduce renal lipid peroxidation, the receptor for AGE, and inducible nitric oxide synthase. Overall, these data suggest that iridoid glycosides and low molecular weight polyphenols purified from Corni Fructus improve metabolic parameters associated with the development of diabetic renal damage. The main active components of these fractions are discussed.

• 社団法人日本薬学会の論文
• 2007-07-01

著者

• Yokozawa Takako

  Institute of Natural Medicine, University of Toyama

• 田中 隆

  長崎大学大学院医歯薬学総合研究科

• Tanaka Takashi

  Graduate School Of Education Hiroshima University

• 松尾 洋介

  長崎大学大学院医歯薬学総合研究科

• Kang Ki

  Inst. Of Natural Medicine Univ. Of Toyama

• Kang Ki

  富山大学和漢医薬学総合研究所

• Kang Ki

  Institute of Natural Medicine, University of Toyama

• Yamabe Noriko

  Institute of Natural Medicine, University of Toyama

• Yamabe Noriko

  富山大学和漢医薬学総合研究所

• Yamabe Noriko

  Institute Of Natural Medicine University Of Toyama

• Yokozawa Takako

  Inst. Of Natural Medicine Univ. Of Toyama

• Yoshikawa T

  Institute Of Natural Medicine University Of Toyama

• MATUSO Yosuke

  Graduate School of Biomedical Sciences, Nagasaki University

• Matsuo Yosuke

  Graduate School Of Biomedical Sciences Nagasaki University

• Matsuo Yosuke

  Graduate School Of Biomedical Sciences Nagasaki Univ.

• Yokozawa Takako

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Kang Ki

  Institute Of Natural Medicine University Of Toyama

• Tanaka Tomonori

  Faculty Of Medical And Pharmaceutical Sciences Kumamoto University

• 田中 隆

  Faculty Of Pharmaceutical Sciences Kyushu University

• Tanaka T

  School Of Pharmaceutical Sciences Nagasaki University

• Kang Ki

  Univ. Toyama Toyama Jpn

• Matuso Yosuke

  Graduate School Of Biomedical Sciences Nagasaki University

• 横澤 隆子

  Inst. Of Natural Medicine Univ. Of Toyama

• Tanaka Takemi

  School Of Agriculture Kyushu Tokai University

• Tanaka Takashi

  Graduate School Of Biomedical Sciences Nagasaki University

• Tanaka Takashi

  Graduate School Of Biochemical Science Nagasaki University

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