Examination of the Nitric Oxide Production-Suppressing Component in Tinospora tuberculata

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概要

• 論文の詳細を見る

• The component of aqueous Tinospora tuberculata extract that inhibits nitric oxide (NO) production was examined using macrophages activated by the addition of lipopolysaccharide. The aqueous extract was partitioned with ethyl acetate. The aqueous layer was fractionated with a Diaion column. The residue of the aqueous extract was extracted with methanol, and partitioned with ethyl acetate. The ethyl acetate layer was found to be associated with a distinct decrease in the NO level and inducible NO synthase. On further fractionation, the subfraction of E-3 showed high anti-NO activity. N-trans-Feruloyltyramine isolated from E-3 was identified as exhibiting strong anti-NO activity. This compound is the most active component of Tinospora tuberculata with respect to the suppression of NO production.

• 公益社団法人日本薬学会の論文
• 2001-10-01

著者

• Yokozawa Takako

  Institute of Natural Medicine, University of Toyama

• 田中 孝幸

  Daiichi Seiyaku Co. Ltd.

• Yokozawa Takako

  富山医科薬科大学和漢医薬学総合研究所

• TANAKA Takashi

  School of Pharmaceutical Sciences, Nagasaki University

• Tanaka T

  Graduate School Of Biomedical Sciences Nagasaki University

• Yokozawa T

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• Yokozawa Takako

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• KIMURA Takeatsu

  Daiichi College of Pharmaceutical Sciences

• Tanaka T

  School Of Pharmaceutical Sciences Nagasaki University

• Kimura T

  Okayama Univ. Okayama Jpn

• Tanaka T

  Tohoku Univ. Sendai Jpn

• Tanaka Takemi

  School Of Agriculture Kyushu Tokai University

• Tanaka Takashi

  School Of Pharmaceutical Sciences Nagasaki University

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