生薬・ウワウルシの薬理学的研究(第3報)免疫性炎症におけるArbutinとIndomethacinの併用効果
スポンサーリンク
概要
- 論文の詳細を見る
A study was carried out to examine the combined effect of arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) SPRENG. (Bearberry leaf) and indomethacin on Type IV allergic reaction-induced immuno-inflammation, carrageenin-induced edema and adjuvant-induced arthritis. Contact dermatitis caused by picryl chloride (PC-CD) and sheep red cell delayed type hypersensitivity (SRBC-DTH) was not inhibited by the oral application of arbutin at 2 divided doses immediately before and 16 h after the application, but arbutin at dose of 50 mg/kg 24 h after the application rapidly decreased the swelling of PC-CD. Arbutin (p. o.) plus indomethacin (s. c.) showed inhibitory effect on the swelling of PC-CD and SRBC-DTH stronger than that of indomethacin alone. When arbutin (p. o.) and indomethacin (s. c.) in a given portion were simultaneously administered, the inhibitory effect was more potent than that of indomethacin alone in both carrageenin-induced edema and adjuvant-induced arthritis. These results suggest that arbutin may increase the inhibitory action of indomethacin on PC-CD, SRBC-DTH, carrageenin-induced edema and adjuvant-induced arthritis, but further investigations are required to understand the mechanism involved.
- 社団法人日本薬学会の論文
- 1991-05-25
著者
-
松田 秀秋
近畿大学薬学部創薬科学科薬用資源学研究室
-
久保 道徳
近畿大学薬学部
-
田中 孝幸
Daiichi Seiyaku Co. Ltd.
-
松田 秀秋
近畿大学 薬学部
-
田中 孝幸
第一製薬株式会社
-
Tanaka T
Graduate School Of Biomedical Sciences Nagasaki University
-
松田 秀秋
近畿大学薬学部
-
Tanaka Takemi
School Of Agriculture Kyushu Tokai University
関連論文
- 青い柑橘類果実でアンチエイジング : 抗アレルギー作用を併せ持つ美白・美肌作用(大学発!美味しいバイオ)
- Hydroxychavicol : a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle
- 薬用人参の蘆頭の薬史学的考証とギンセノシド類の組成
- Pharmacological study on Panax ginseng C. A. MEYER. XVI. Improving effects of Red Ginseng on peripheral circulation disorder
- 天然資源からの育毛生薬の探索 (特集 育毛剤開発の現状と課題)
- 抗糖尿病性機能性食品の血糖降下作用
- コーカサス型発酵乳ケフィアの薬理活性研究(第1報)抗腫瘍活性について その1
- わが国固有の柑橘類果実の薬史学的考証から見出された有用性について
- インドメメタシンのヘアレラット皮膚透過に対する呉茱萸の促進作用
- I-A-3 漢薬・地黄の生薬薬理学的研究(第 3 報) : 血流を指標にした地黄の修治と薬能