地黄の研究(第4報) : 熟地黄50%エタノール抽出エキスの血行動態に及ぼす影響(その2)

概要

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The effects of 50% ethanolic extract (JR-ext) prepared from Steamed Rehmanniae Radix (the steamed root of Rehmannia glutinosa LIBOSH, "Juku-Jio" in Japanese) on hemodynamics were investigated in rats. JR-ext activated pyruvate kinase activity, rate-limiting enzyme in erythrocyte glycolytic pathway that closely relates to erythrocyte ATP content and its rheological properties, and increased the ratio of young erythrocytes in whole blood. JR-ext increased erythrocyte count, and locomotor activity after forced running (3 m/min × 8 hr), in iron-deficient anemic rats. Also, JR-ext had an inhibitory effect on decrease of hypodermic temperature in back of rats under 4℃, and promotional effect on recovery of hypodermic temperature after water-immersion. These results suggest that JR-ext enhanced the erythrocyte properties in quantity and quality, would promote the exchanges of oxygen and carbon dioxide in peripheral tissue, and consequently activate vital life activity.
2003-12-20