未熟温州ミカンエキスのラット経口投与時におけるヘスペリジンおよびヘスペレチンの消化管吸収性

概要

論文の詳細を見る
Hesperidin and hesperetin having an antiallergic effect are contained abundantly in immature fruit of Citrus unshiu. However, the gastrointestinal absorption of hesperidin and hesperetin as an aglycone of hesperidin after oral administration of Citrus unshiu extract (CU-ext) has not been clarified. We developed a simultaneous HPLC analysis for hesperidin and hesperetin in plasma and investigated the pharmacokinetics of hesperidin and hesperetin after oral administration of CU-ext compared with that after hesperidin solution or suspension in rats. Much higher plasma concentrations of hesperidin and hesperetin were observed after administration of CU-ext compared to those after hesperidin suspension. The maximum plasma concentration (Cmax) and bioavailability of hesperidin was 835 ng/mL and 3.5-7%, respectively, after administration of CU-ext (200 mg/kg), although respective values after hesperidin suspension were only 144 ng/mL and 0.5-1.5%. Comparison of the ratio of AUC o fhesperetin to that of hesperidin also demonstrated that a part of hesperidin was absorbed after conversion to hesperetin. This study showed that the form of CU-ext could promote the absorption of hesperidin.
2008-02-20