薬用人参の薬理学的研究(第7報) 紅参の感染防御作用その1 マウス網内系の貪食活性化作用

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Effects of 70% methanol extract (I) from Red Ginseng (steamed and dried root of Panax ginseng C. A. MEYER) on the phagocytic activity of mouse reticuloendotherial system were studied by the carbon clearance method in normal mice, carrageenan or cyclophosphamide-treated mice. In normal mice, the clearance-rate of carbon was shortened 1 h after the administration of I (50,200 or 500 mg/kg, p.o., one time, one time/d for 3 d or one time/d for 5 d). Microscopically, carbon particles were internalized mainly by Kupffer cells in the liver and in the spleen, by macrophage (Mφ) of marginal zones between white and red pulp. I (200 or 500 mg/kg, p.o., one time/d for 3 d) activated the phagocytosis of carbon by Kupffer cells in the liver and Mφ in the spleen. In carrageenan (injurious agent of Mφ)-treated mice, I (200 or 500 mg/kg, p.o.) was not found to show the shortening of the clearance rate of carbon. However, in cyclophosphamide (injurious agent of leukocyte)-treated mice, the clearance-rate of carbon was shortened by the oral administration of I (200 or 500 mg/kg, p.o.). These results suggested that 70% methanol extract from Red Ginseng promotes the phagocytic activity on the reticuloendotherial system in mice and has a stimulatory effect on Mφ.
公益社団法人日本薬学会の論文
1985-10-25