柑橘類果実の薬理学的研究(第1報)ウンシュウミカン果実の抗アレルギー作用その1

概要

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A study was carried out to examme the effect of 50% ethanolic extract from green fruit of Citrus unshiu MARKOVICH on type I, II and IV allergic reactions. Forty eight-hour homologous passive cutaneous anaphylaxis (PCA) in rats as a typical model of the type I reaction was significantly inhibited by the oral administration of the extract. Complement-dependent cytolysis of sheep red blood cell as a typical model of the type II reaction was significantly inhibited by incubation with it. Contact dermatitis in mice as a model of the type IV reaction caused by picryl chloride or sheep red blood cell was significantly inhibited by the oral application of it. The anti-allergic actions decreased with the growth of fruit of Citrus unshiu. These results suggested that the 50% ethanolic extract from green fruit of Citrus unshiu have anti-allergic actions against the type I, II and IV reactions.
公益社団法人日本薬学会の論文
1989-11-25