生薬・マムシの薬理活性研究(第1報)50%エタノールエキスの実験的胃潰瘍に対する作用

概要

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Anti-ulcerogenic activities of a 50% ethanolic extract ([M]) from whole body of Agkistrodon blomhoffii blomhoffii BOIE were investigated in rats. [M] at oral doses of 250-500 mg/kg was found to show a prophylactic effect on the water-immersion stress-and ethanol-induced ulcer and a remedial effect on acetic acid-induced ulcer, but not Shay-ulcer in pylorus-ligated rats and indomethacin-induced ulcer. [M] increased the gastric mucosal blood flow in intact rats and improved the decrease of the blood flow in acetic acid-induced ulcer rats. [M] inhibited the decrease in content of hexosamine of gastric mucosa in rats treated with acetic acid. These results suggest that [M] have a prophylactic effect on ulcerogenics, and an anti-ulcer effect by the increase and/or maintenance of gastric mucosal blood flow and hexosamine, but further investigations are required to understand the mechanism involved.
社団法人日本薬学会の論文
1989-08-25