Experimental Renal Failure Rats Induced by Adenine -Evaluation of Free Amino Acid, Ammonia Nitrogen and Guanidino Compound Levels-
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概要
- 論文の詳細を見る
The levels of free amino acid, ammonia nitrogen and guanidino compounds were examined in renal failure rats induced by adenine. Among the essential amino acids in the serum, the marked reduction of lysine, valine, leucine and isoleucine was confirmed in the adenine-fed group as compared with the control group. Tyrosine and ornithine were also significantly reduced in the adenine-fed rats, while glycine, arginine and aspartic acid were significantly elevated. The urinary excretion of leucine, isoleucine and non-essential amino acids (glutamic acid, histidine, aspartic acid, citrulline, tyrosine, ornithine) was found to be high. On the other hand, adenine administered orally caused hyperammonemia. Furthermore, the results of the present study show that intake of adenine increased extraordinarily the level of guanidinosuccinic acid and methylguanidine in the serum, while the value of serum guanidinosuccinic acid and methylguanidine in rats fed on a control diet was not detectable.
- 社団法人 日本農芸化学会の論文
著者
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Yokozawa T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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YOKOZAWA Takako
Department of Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical Uni
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ZHENG Ping
Department of Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical Uni
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OURA Hikokichi
Department of Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical Uni
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Yokozawa Takako
Department Of Applied Biochemistry Research Institute For Wakan-yaku Toyama Medical And Pharmaceutic
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OURA Hikokichi
Department of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
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ZHENG Ping
Department of Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
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ZHENG Ping
Department of Biochemistry, Research Institute for Wakan- Yaku, Toyama Medical and Pharmaceutical University
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OURA Hikokichi
Department of Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
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