The Protective Role of Chinese Prescription Kangen-karyu Extract on Diet-Induced Hypercholesterolemia in Rats(Pharmacognosy)
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概要
- 論文の詳細を見る
This study was carried out to investigate the protective potential of Chinese prescription Kangen-karyu, comprising six crude drugs, on coronary heart disease which is the principal cause of morbidity and mortality worldwide. The diet-induced hypercholesterolemic rat model, which shows an elevation in low density lipoprotein (LDL) cholesterol and atherosclerosis, was employed. The control rats fed a diet of 1% cholesterol and 0.5% cholic acid showed the highest cholesterol levels in serum and feces relative to those fed a normal diet, however, the rats administered Kangen-karyu extract showed reductions in these levels without changes in liver cholesterol, indicating that the reduction of serum total cholesterol by Kangen-karyu extract probably arises from an increase in cholesterol excretion. Furthermore, the administration of Kangen-karyu extract significantly prevented the elevation of serum aspartate aminotransferase and alanine aminotransferase, known as marker enzymes of liver damage. The elevated serum levels of LDL cholesterol were lowered, however, the high density lipoprotein cholesterol level was significantly elevated by Kangen-karyu extract and these were dose-dependent decreases in the atherogenic index to 15.2, 8.8 and 7.5 at oral doses of 50, 100 and 200mg from the 19.4 control value, respectively. In addition, Kangen-karyu extract inhibited LDL oxidation in a dose-dependent manner, and the elevated level of thiobarbituric acid-reactive substances in control rats showed a decline by the administration of Kangen-karyu extract. The present study suggests that Kangen-karyu could play a protective role against hypercholesterolemia through the regulation of cholesterol levels and inhibition of lipid peroxidation.
- 社団法人日本薬学会の論文
- 2006-04-01
著者
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Yokozawa Takako
Institute of Natural Medicine, University of Toyama
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横澤 隆子
富山医科薬科大学和漢薬研究所
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中川 孝子
富山大学和漢医薬学総合研究所漢方診断学部門
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Yokozawa Takako
富山医科薬科大学和漢医薬学総合研究所
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Yokozawa Takako
Univ. Toyama Toyama Jpn
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Yoshikawa T
Institute Of Natural Medicine University Of Toyama
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OKAMOTO Takuya
Iskra Industry Co., Ltd.
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SEI Yasuo
Iskra Industry Co., Ltd.
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Cho Eun
Department Of Food Science And Nutrition Pusan National University
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NAKAGAWA Takako
Department of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama
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横澤 隆子
富山大学和漢医薬学総合研究所
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Sei Yasuo
Iskra Industry Co. Ltd.
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Yokozawa T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Yokozawa Takako
Institute Of Natural Medicine University Of Toyama
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Yokozawa Takako
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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SATOH Akiko
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Satoh Akiko
Institute Of Natural Medicine University Of Toyama
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Satoh Akiko
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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SASAKI Sumiyo
Institute of Natural Medicine, University of Toyama
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Okamoto Takuya
Iskra Industry Co. Ltd.
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Okamoto T
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy:iskura Industry Co. Ltd.
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Sei Yasuo
福岡大学 薬学部臨床疾患薬理学教室
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Cho Eun
Department Of Dermatology St Vincent Hospital College Of Medicine The Catholic University Of Korea
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Okamoto Takuya
福岡大学 薬学部臨床疾患薬理学教室
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横澤 隆子
富山医科薬科大学和漢薬研究所細胞資源工学部門
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Sasaki Sumiyo
富山大学和漢医薬学総合研究所
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Sasaki Sumiyo
Institute Of Natural Medicine University Of Toyama
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横澤 隆子
Inst. Of Natural Medicine Univ. Of Toyama
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Nakagawa Takako
Department Of Kampo Diagnostics Institute Of Natural Medicine University Of Toyama
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Nakagawa Takako
Department Of Japanese Oriental Medicine Toyama Medical And Pharmaceutical University
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Cho Eun
Department Of Chemistry Yeungnam University
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岡本 拓也
摂南大学薬学部薬品物性化学研究室
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CHO Eun
Department of Animal Science and Biotechnology, Gyeongnam National University of Science and Technology
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