Oren-gedoku-to and Keishi-bukuryo-gan-ryo Inhibit the Progression of Atherosclerosis in Diet-Induced Hypercholesterolemic Rabbits(Pharmacognosy)
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概要
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In this study, we examined whether the Kampo formulas Oren-gedoku-to (OGT, Huanglian-jie-du-tang in Chinese) and Keishi-bukuryo-gan-ryo (KBG, Gui-zhi-fu-ling-wan in Chinese) could prevent the progression of atherosclerosis in cholesterol-fed rabbit, an animal model for hypercholesterolemia in vivo. Twenty-four male Japanese white rabbits (2 kg body weight) were divided into four groups. The control group was fed standard rabbit chow containing 1% cholesterol, the OGT group was fed standard rabbit chow containing 1% cholesterol and 1% OGT, the KBG group was fed standard rabbit chow containing 1% cholesterol and 1% KBG, and the vitamin E group was fed standard rabbit chow containing 1% cholesterol and vitamin E (450 mg/1000 g). All four groups were kept on these diets for 8 weeks. At the end of the experiments, the percentage of surface area of the total thoracic aorta with visible plaque was significantly reduced in the OGT and KBG groups. The serum thiobarbituric acid reactive substances of the vitamin E group showed a significantly low value compared with the control group, whereas the serum lipid peroxide levels of the OGT and KBG groups were considerably lower than that of the control groups as well as that of the vitamin E group. Furthermore, the urinary 8-hydroxy-deoxyguanosine levels of the OGT and KBG groups were considerably lower than that of the vitamin E group. These results suggest that OGT and KBG prevent the progression of atheromatous plaque by creating a sounder antioxidant defense system than vitamin E.
- 社団法人日本薬学会の論文
- 2005-02-01
著者
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横澤 隆子
富山医科薬科大学和漢薬研究所
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Terasawa Katsutoshi
群馬大学 医学部医学科統合和漢診療学講座
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中川 孝子
富山大学和漢医薬学総合研究所漢方診断学部門
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Yokozawa Takako
Univ. Toyama Toyama Jpn
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Yoshikawa T
Institute Of Natural Medicine University Of Toyama
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SEKIYA Nobuyasu
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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HIKIAMI Hiroaki
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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KOUTA Kazufumi
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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SHIMADA Yutaka
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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TERASAWA Katsutoshi
21st Century COE Program, Toyama Medical and Pharmaceutical University
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Terasawa K
Dept. Of Japanese Oriental Medicine Graduate School Of Medicine Chiba University
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寺澤 捷年
富山医科薬科大・和漢診療学教室
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SHIBAHARA Naotoshi
Department of Kampo Diagnostics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Un
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Shimada Y
Dept. Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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NAKAGAWA Takako
Department of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama
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KAINUMA Mosaburo
Department of Japanese Oriental (Kampo) Medicine, Oriental Medical Center, Iizuka Hospital
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横澤 隆子
富山大学和漢医薬学総合研究所
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Shimada Y
Tokyo Inst. Technol. Yokohama Jpn
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Kita T
Department Of Integrated Japanese Oriental Medicine School Of Medicine Gunma University
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Shimada Y
Institute Of Multidisciplinary Research For Advanced Materials Tohoku University
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Shimada Yuji
Microsystem Research Center Precision And Intelligence Laboratory Tokyo Institute Of Technology
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Shimada Y
Tohoku Univ. Sendai Jpn
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島田 洋蔵
産業技術総合研究所
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Sekiya Nobuyasu
Department Of Japanese Oriental Medicine Faculty Of Medicine
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嶋田 豊
富山医科薬科大学医学部和漢診療学
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Shibahara Naotoshi
Department Of Kampo Diagnostics Institute Of Natural Medicine University Of Toyama : 21st Century Co
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Shibahara Naotoshi
Department Of Japanese Oriental (kampo) Medicine Toyama Medical And Pharmaceutical University
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横澤 隆子
富山医科薬科大学和漢薬研究所細胞資源工学部門
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Kouta Kazufumi
Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive
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Terasawa Katsutoshi
21st Century Coe Program University Of Toyama:department Of Japanese Oriental Medicine Graduate Scho
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Kita T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Sekiya N
Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive
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Nakagawa Takako
Department Of Kampo Diagnostics Institute Of Natural Medicine University Of Toyama
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Nakagawa Takako
Department Of Japanese Oriental Medicine Toyama Medical And Pharmaceutical University
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Nakagawa Takako
Department Of Anesthesia Ntt West Hospital
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Hikiami Hiroaki
富山大学 大学院医学薬学研究部和漢診療学講座
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Hikiami Hiroaki
Department Of Japanese Oriental Medicine Graduate School Of Medical And Pharmaceutical Sciences Univ
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Shibagaki Yukari
富山大学和漢医薬学総合研究所
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島田 洋蔵
Dept. Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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Shimada Yutaka
Department Of Anatomy And Cell Biology School Of Medicine Chiba Unversity
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Shimada Yutaka
21^<st> Century Coe Program Toyama Medical And Pharmaceutical University
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Kainuma Mosaburo
Department Of General Internal Medicine Kyushu University Hospital
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Kainuma Mosaburo
Department Of Japanese Oriental (kampo) Medicine Oriental Medical Center Iizuka Hospital
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Terasawa Katsutoshi
21st Century Coe Program University Of Toyama
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Shimada Nobuyasu
Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive
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Shimada Yutaka
Department Of Anatomy And Cell Biology School Of Medicine Chiba University
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Kainuma Mosaburo
Department Of General Internal Medicine Kyushu University
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HIKIAMI Hiroaki
Department of Japanese Oriental (Kampo) Medical Center, Suwa Central Hospital
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