Evaluation of Oriental medicines using a cultured renal epithelial cell line, LLC-PK_1 : Effects of Carthami Flos, Rhei Rhizoma and Astragali Radix

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rights: 本文データは和漢医薬学会の許諾に基づき複製したものであるThe effects of Carthami Flos，Rhei Rhizoma and Astragali Radix extract，which have been proved to ameliorate renal failure in rats with glycerol-induced renal failure，were examined in cell culture under three different culture conditions．Rhei Rhizoma　extract showed the most potent effect among the three crude drugs under any of the routine，hypoxia-reoxygenation and cisplatin exposure conditions employed，suggesting that its favorable effect on proximal tubule function is due to suppression　of lipid peroxidation via free radicals．In contrast，this anti-cytotoxic activity was low in Astragali Radix extract，and almost nil in Carthami Flos extract．These results indicate that Rhei Rhizoma，Astragali Radix and Carthami Flos exert their actions on different sites in the kidney．
和漢医薬学会の論文
1998-01-01