Protective activity from hydrophilic and lipophilic free radical generators of Wen-Pi-Tang and its crude drug extracts in LLC-PK_1 cells
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概要
- 論文の詳細を見る
水溶性アゾ化合物のAAPH(2,2'-azobis(2-amidino-propane)dihydrochloride)と脂溶性アゾ化合物のAMVN(2,2'-azobis(2,4dimethylvaleronitrile))で腎上皮細胞のLLC-PK1に酸化的ストレスを惹起させ,温脾湯と5種類の構成和漢薬の効果を検討した。AAPHとAMVNで処埋した場合,細胞生有率が著しく抵ドし,チオバルビツール酸反応物質の生成が著しく上昇したが,温脾湯と各構成和漢薬エキスをそれぞれ添加した場合,温脾湯と大黄,薬用人参では高い抗酸化活性を示した。しかし附子,乾姜,甘草では相対的に低いi活牲であった。このことから,温脾湯の抗酸化活性は構成和漢薬に起因し,また温脾湯は水溶性抗酸化物と脂溶性抗酸化物の両方の特徴を有していることが示唆された。
- 2000-12-15
著者
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PARK Jong
Department of Internal Medicine, Chonnam National University Hospital
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横澤 隆子
富山医科薬科大学和漢薬研究所
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TERASAWA Katsutoshi
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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MITSUMA Tadamichi
Department of Japanese Oriental Medicine, Iizuka Hospital
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横澤 隆子
富山大学和漢医薬学総合研究所
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Rhyu Dong
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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RHYU Dong
富山医科薬科大学和漢薬研究所
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CHO Eun
富山医科薬科大学和漢薬研究所
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Mitsuma Tadamichi
Department Of Japanese Oriental Medicine (kampo) Oriental Medical Center Iizuka Hospital
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Mitsuma Tadamichi
Department Of Japanese Oriental (kampo) Medicine Iizuka Hospital
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Mitsuma Tadamichi
Department Of Japanese Oriental Medicine Iizuka Hospital
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横澤 隆子
富山医科薬科大学和漢薬研究所細胞資源工学部門
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Park Jong
Department Of Oriental Medicine Resource College Of Natural Science Sunchon National University
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Terasawa Katsutoshi
Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive
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Park Jong
Department Mathematics Pusan National University
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Terasawa Katsutoshi
Department Of Japanese Oriental (kampo) Medicine Faculty Of Medicine Toyama Medical And Pharmaceutic
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Terasawa Katsutoshi
Department Of Integrated Japanese Oriental Medicine School Of Medicine Gunma University
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TERASAWA Katsutoshi
Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University
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