Early Statin Therapy Within 48 Hours Decreased One-Year Major Adverse Cardiac Events in Patients With Acute Myocardial Infarction
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概要
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HMG-CoA reductase inhibitors (statins) reduce major adverse cardiac events (MACE) and mortality in patients with acute coronary syndrome. We investigated whether early statin therapy would be effective at reducing MACE in patients with acute myocardial infarction (AMI).A total of 1,159 patients were analyzed. They were grouped by initiation time of statin administration after admission as follows: group I; n = 945, ≤ 48 hours, group II; n = 214, > 48 hours.Cardiovascular risk factors and noncardiac comorbidities were not different between the two groups. ST-elevation MI as initial diagnosis was more prevalent in group I (68.4% versus 59.3%, P = 0.013). In-hospital mortality was not different in the two groups (0.8% versus 0.5%, P = 0.483). In one-year clinical follow-up, MACE and repercutaneous coronary intervention were lower in group I (17.8% versus 24.6%, P = 0.016, 10.2% versus 15.5%, P = 0.021, respectively). However, there was no difference in mortality (3.8% versus 4.7%, P = 0.319). In multivariate analysis, statin initiation within 48 hours after admission was an independent predictor of one-year MACE (OR 1.49, 95% CI = 1.00-2.21, P = 0.045).Consequently, early statin therapy within 48 hours after admission reduced MACE at one-year follow-up in patients with AMI.
著者
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JEONG Myung
Department of Internal Medicine, Chonnam National University Hospital
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KIM Min
Department of Internal Medicine, Chonnam National University Hospital
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CHO Kyung
Department of Internal Medicine, Chonnam National University Hospital
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LEE Min
Department of Internal Medicine, Chonnam National University Hospital
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KO Jum
Department of Internal Medicine, Chonnam National University Hospital
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PARK Keun
Department of Internal Medicine, Chonnam National University Hospital
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SIM Doo
Department of Internal Medicine, Chonnam National University Hospital
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YOON Nam
Department of Internal Medicine, Chonnam National University Hospital
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YOON Hyun
Department of Internal Medicine, Chonnam National University Hospital
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PARK Hyung
Department of Internal Medicine, Chonnam National University Hospital
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KIM Ju
Department of Internal Medicine, Chonnam National University Hospital
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HONG Young
Department of Internal Medicine, Chonnam National University Hospital
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CHO Jeong
Department of Internal Medicine, Chonnam National University Hospital
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PARK Jong
Department of Internal Medicine, Chonnam National University Hospital
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KANG Jung
Department of Internal Medicine, Chonnam National University Hospital
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Ahn Youngkeun
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University
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Kim Kye
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University
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Lee Min
Department Of Aeronautics And Astronautics Kyushu University
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Park Jong
Department Mathematics Pusan National University
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YOON Hyun
Department of Biological Sciences, Korea Advanced Institute of Science and Technology
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Jeong Myung
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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Kim Kye
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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Park Hyung
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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Kim Ju
Department of Cardiology, Chonnam National University Hospital
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Cho Jeong
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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Kang Jung
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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Park Keun
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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Park Jong
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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Sim Doo
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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KIM Min
Department of Animal Science and Biotechnology, College of Agriculture and Life Science, Chungnam National University, Daejeon 305–764, Korea
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Kim Min
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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Cho Kyung
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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Yoon Nam
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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Ko Jum
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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Hong Young
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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Kim Ju
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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