Saeng-Maek-San, a Medicinal Herb Complex, Protects Liver Cell Damage Induced by Alcohol

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概要

• 論文の詳細を見る

• The effect of treatment with Saeng-Maek-San (SMS) Complex (SMS1 or SMS2) upon rat hepatocytes exposed to alcohol was investigated. We compared the serum biochemistry and liver histology of rats administered both alcohol and SMS to control rats treated with alcohol alone. SMS treatment resulted in a significant reduction in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and triglycerides (TG) compared to the control rats. In contrast, expression levels of alcohol dehydrogenase (ADH) were increased. Electron microscopy indicated that administration of SMS preserved the structure of organelles, including the nucleus and mitochondria. In addition, lipid droplets and secondary lysosomes were observed in the control rats. These data suggest that SMS represents an excellent candidate for protection of rat hepatocytes from alcoholmediated damage.

• 社団法人日本薬学会の論文
• 2002-11-01

著者

• LEE Min

  Department of Internal Medicine, Chonnam National University Hospital

• Kim Kang

  Department Of Theoretical And Computational Molecular Science Institute For Molecular Science

• Kim K

  Yong-in Univ. Yongin‐si Kor

• LEE Hyung

  Department of Physics and Astronomy, FPRD, Seoul National University

• Lee S‐h

  Wonkwang Univ. Jeonbuk Kor

• Kim K‐s

  Department Of Food And Nutrition Yong-in University

• PARK Kap

  Department of Biological Sciences, Konkuk University

• KANG Hyunmin

  Department of Life Science, Yong-In University

• LEE Sang-Han

  Corea Research Institute of Bioscience & Biotechnology (KRIBB)

• CHO Jkhyun

  College of Veterinary Medicine, Konkuk University

• Park K

  Konkuk Univ. Seoul Kor

• Lee S‐h

  College Of Pharmacy Yeungnam University

• Lee Sang-han

  Corea Research Institute Of Bioscience & Biotechnology (kribb)

• Lee H

  Konkuk Univ. Seoul Kor

• Lee Hyung

  Department Of Chemistry Bk21 School Of Chemical Materials Science And Skku Advanced Institute Of Nan

• Park Kap

  Department Of Biological Sciences Konkuk University

• Cho Jkhyun

  College Of Veterinary Medicine Konkuk University

• Kang Hyunmin

  Department Of Life Science Yong-in University

• Lee Min

  Department Of Biological Sciences Konkuk University

• Kim Kang

  Department Of Computational Molecular Science Institute For Molecular Science

• Lee Min

  Department Of Aeronautics And Astronautics Kyushu University

• Lee Hyung

  Department Of Biological Sciences Konkuk University

• Kim Kang

  Department of Applied Physics, Hanyang University, Sa-1 Dong, Ansan 426-791, Korea

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