Protective Effects of Isoliquiritigenin Against Methamphetamine-Induced Neurotoxicity in Mice
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概要
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Isoliquiritigenin (ISL) suppresses cocaine-induced extracellular dopamine levels and has a neuroprotective effect in cocaine-treated rat brain. Here, we examine the effect of ISL on methamphetamine-induced striatal neurotoxicity. Repeated injections of methamphetamine cause the loss of striatal dopamine transporter (DAT) and tyrosine hydroxylase (TH). Intraperitoneal injection of ISL prior to methamphetamine injection significantly prevented methamphetamine-induced reduction of DAT and TH. ISL also suppressed methamphetamine-induced activation of glial cells. Moreover, ISL impeded the expression of nitric oxide synthase and the activation of NF-κB through blockage of its phosphorylation. Our results suggest that ISL protects against methamphetamine-induced neurotoxicity by inhibition of NF-κB activation.
- 2009-10-20
著者
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LEE Min
Department of Internal Medicine, Chonnam National University Hospital
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YANG Chae
Department of Physiology, Daegu Haany University
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JEON Jae-Pil
Division of Biobank for Health Sciences, Korea National Institute of Health
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HWANG Meeyul
The Research Center for Biomedical Resource of Oriental Medicine, Daegu Haany University
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Yang Chae
Department Of Physiology Daegu Haany University
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Yang Chae
Department Of Physiology College Of Oriental Medicine Daegu Haany University
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Hwang Meeyul
The Research Center For Biomedical Resource Of Oriental Medicine Daegu Haany University
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Lee Min
Department Of Physiology Daegu Haany University
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Jeon Jae-pil
Division Of Biobank For Health Sciences Korea National Institute Of Health
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Lee Min
Department Of Aeronautics And Astronautics Kyushu University
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Yang Chae
Department Of Oriental Medicine College Of Oriental Medicine
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Hwang Meeyul
The Res. Center For Biomedical Resource Of Oriental Medicine Daegu Haany Univ. Kor
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