Fritillaria ussuriensis Extract Inhibits the Production of Inflammatory Cytokine and MAPKs in Mast Cells
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概要
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Fritillaria ussuriensis (FU, derived from the bulbs of various species of the genus Fritillaria, including Fritillaria thunbergii Miq.) is used in herbal medicine to treat conditions such as eczema, skin burns, and frostbite. In this study, we investigated the mechanism of the anti-allergy effect of FU. FU extract (80 mg/kg), orally administered to Sprague-Dawley (SD) rats, significantly inhibited the passive cutaneous anaphylaxis (PCA) reaction. It inhibited the compound 48/80-induced release of histamine from rat peritoneal mast cells in a concentration-dependent manner. Significant inhibitory effects of the FU extract on IL-6, IL-8, and TNF-α (1, 10, and 100 μg/mL) were observed in HMC-1 cells. Treatment with FU attenuated PMA plus A23187-induced phosphorylation of all three MAPKs, especially at concentrations of 10 and 100 μg/mL. Further, it (80 mg/kg) led to significant inhibition of mast-cell accumulation in ear tissue at the chronic phase. These results indicate that it inhibits allergic reactions.
- 2011-08-23
著者
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SOHN Youngjoo
College of Oriental Medicine, Sangji University
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Kim Jong-hyun
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Lee Min
Department Of Aeronautics And Astronautics Kyushu University
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Cho Ik-hyun
Department Of Anatomy Jeju National University School Of Medicine
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Han Na
Department Of Anatomy College Of Oriental Medicine Institute Of Oriental Medicine Kyung Hee Universi
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Jung Hyuk-sang
Department Of Anatomy College Of Oriental Medicine Institute Of Oriental Medicine Kyung Hee Universi
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Shin Kyu
Department Of Anatomy College Of Oriental Medicine Institute Of Oriental Medicine Kyung Hee Universi
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Lee Min
Department Of Anatomy College Of Oriental Medicine Institute Of Oriental Medicine Kyung Hee Universi
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Kim Jong-hyun
Department Of Anatomy College Of Oriental Medicine Institute Of Oriental Medicine Kyung Hee Universi
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Cho Ik-hyun
Department Of Anatomy College Of Oriental Medicine Institute Of Oriental Medicine Kyung Hee Universi
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Sohn Youngjoo
College Of Oriental Medicine Sangji University
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