Protective Effects of Cuscutae semen against Dimethylnitrosamine-Induced Acute Liver Injury in Sprague-Dawley Rats(Pharmacology)

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概要

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• We investigated the protective effect of Cuscutae semen (CS) on acute liver injury induced by dimethylnitrosamine (DMN) in Sprague-Dawley rats. CS is an important traditional herbal medicine widely used as a tonic and aphrodisiac to nourish the liver and kidney and to treat impotence and seminal emission. Rats were given a single intraperitoneal injection of DMN (40 mg/kg), and were then treated with CS daily by oral gavage for 4 d. Immunohistochemical studies for alpha-smooth muscle actin (α-SMA) and proliferating cell nuclear antigen (PCNA) were performed, along with hydroxyproline and biological assay. Liver injury caused by DMN-injection was significantly inhibited in the CS-treated group compared to the silymarin-treated group. The results of blood biological assay were significantly protected by CS in serum total protein (T-protein), T-bilirubin (T-bili), D-bilirubin (D-bili), GOT, GPT, and ALP. The hydroxyproline content and amount of active α-SMA and PCNA were significantly decreased in the CS-treated group than in the silymarin-treated group. CS exhibited an in vivo hepatoprotective effect and anti-fibrogenic effects against DMN-induced acute liver injury and inhibited the formation of hydroxyproline, which suggests that CS may be useful in preventing fibrogenesis after liver injury.

• 公益社団法人日本薬学会の論文
• 2007-08-01

著者

• Jeong Hyun-ja

  Coll. Of Oriental Medicine And Inst. Of Oriental Medicine Kyung Hee Univ.

• SOH Yunjo

  Department of Dental Pharmacology, School of Dentistry, Chonbuk National University

• SOHN Nak-Won

  Graduate School of East-West Medicine, Kyung Hee University

• Jeong Hyun-ja

  Dep. Of Anatomy School Of Medicine Chonbuk National Univ.

• Na Ho-jeong

  韓国

• KIM Eun

  Department of Phpysics, Hanyang University

• Kim Hyung-min

  韓国

• KIM Eun-Young

  Department of Biotechnology, Pukyong National University

• Kim Yun-kyung

  韓国

• Sohn Nak-won

  Graduate School Of East-west Medicine Kyung Hee Univ.

• Jeong H‐j

  Dep. Of Oriental Pharmacy Wonkwang Univ.

• Kim H‐m

  Kyung Hee Univ. Seoul Kor

• Kim Eun-young

  Department Of Biotechnology Pukyong National University

• Soh Yunjo

  Dep. Of Dental Pharmacology School Of Dentistry Chonbuk National Univ.

• Jung Hyuk-sang

  Department Of Anatomy College Of Oriental Medicine Kyung Hee University

• Na Ho‐jeong

  College Of Pharmacy Wonkwang University

• Kim Hyung‐min

  Dep. Of Anatomy School Of Medicine Chonbuk National Univ.

• Kim H‐m

  Yonsei Univ. School Of Medicine

• LEE Hyun-Sam

  Department of Anatomy, College of Oriental Medicine, Kyung Hee University

• SOHN Youngjoo

  Deparment of Gynecology, College of Oriental Medicine, Sangji University

• SOHN Nak-Won

  Department of Anatomy, College of Oriental Medicine, Kyung Hee University

• Soh Yunjo

  Graduate School Of East-west Medical Science Kyung Hee University

• Soh Yunjo

  Department Of Biological Sciences Auburn University

• Jung H‐a

  Coll. Of Oriental Medicine And Inst. Of Oriental Medicine Kyung Hee Univ.

• Na Ho‐jeong

  Dep. Of Pharmacology Coll. Of Oriental Medicine Inst. Of Oriental Medicine Kyung Hee Univ.

• Seo Youngwan

  Division Of Ocean Science Korea Maritime University

• Kim Eun-young

  College Of Oriental Medicine And Institute Of Oriental Medicine Kyung Hee University

• Lee Hyun-sam

  College Of Oriental Medicine And Institute Of Oriental Medicine Kyung Hee University

• Kim Eun

  Department Of Anesthesia And Pain Medicine School Of Medicine Pusan National University

• Jung Hyuk-sang

  Department Of Anatomy College Of Oriental Medicine Institute Of Oriental Medicine Kyung Hee Universi

• KIM Eun

  Department of Agricultural Biotechnology, Seoul National University

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