The Immune-Enhancing Effect of the Herbal Combination Bouum-Myunyuk-Dan(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
The herbal formulation Bouum-Myunyuk-Dan (BMD) has long been used for various diseases. It has been shown to have antimicrobial and anti viral activity clinically. However, it is still unclear how BMD exerts these effects in experimental models. In this study, we investigated the effect of BMD on the production of cytokines in a human T cell line, MOLT-4 cells, and in mouse peritoneal macrophages. As a result, BMD significantly increased the viability and proliferation of splenocytes (p<0.05) and also significantly increased interleukin (IL)-2 and IL-4 production compared with media control (about 2.7-fold for IL-2 and 6.7-fold for IL-4,p<0.05) after 24 h. BMD increased the interferon (IFN)-γ production by 3.7-fold but there were no significant differences compared with controls. Maximal effective concentrations of BMD were 1 mg/ml for IL-2 and IL-4 and 0.1 mg/ml for IFN-γ. In addition, BMD (0.01 mg/ml) increased the production of tumor necrosis factor (TNF)-α and IL-12 in mouse peritoneal macrophages (by 2.7-fold for TNF-α and 42.5-fold for IL-12, p<0.05). In conclusion, these data indicate that BMD may have an immune-enhancing effect through the production of various cytokines.
- 社団法人日本薬学会の論文
- 2004-01-01
著者
-
Jeong Hyun-ja
Coll. Of Oriental Medicine And Inst. Of Oriental Medicine Kyung Hee Univ.
-
Jung Hyuk-sang
Biochip Research Center Hoseo University
-
Jeong Hyun-ja
Dep. Of Anatomy School Of Medicine Chonbuk National Univ.
-
Kim Hyung-Min
Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee
-
Na Ho-jeong
韓国
-
AN Hyo-Jin
College of Oriental Medicine, Kyung Hee University
-
AN Hyo-Jin
Department of Pharmacology, College of Oriental Medicine. Kyung Hee University
-
CHUNG Hwan-Suck
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University
-
JEONG Hyun-Ja
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University
-
An Hyo-jin
College Of Oriental Medicine Kyung Hee University
-
An Hyo-jin
韓国
-
An Hyo-jin
Department Of Pharmacology College Of Oriental Medicine Kyung Hee University
-
Kim Hyung-min
韓国
-
Jeong H‐j
Dep. Of Oriental Pharmacy Wonkwang Univ.
-
AHN Kyoo-Seok
Department of Food and Nutrition, Chung-Ang University
-
SEO Sang-Wan
Department of Pharmacology, College of Oriental Medicine, Kyung Hee University
-
KIM Tae-gyun
College of Oriental Medicine, Wonkwang University
-
WON Jin-Hee
College of Oriental Medicine, Wonkwang University
-
SHIN Jo-Young
College of Oriental Medicine, Wonkwang University
-
Jung H‐s
Division In Anatomy And Developmental Biology Department Of Oral Biology College Of Dentistry Yonsei
-
Kim H‐m
Kyung Hee Univ. Seoul Kor
-
Kim Hyung
College Of Oriental Medicine Kyung Hee University
-
Kim Hyung-min
Department Of Pharmacology College Of Oriental Medicine Kyung Hee University
-
Jung Hyuk-sang
Department Of Anatomy College Of Oriental Medicine Kyung Hee University
-
Na Ho‐jeong
College Of Pharmacy Wonkwang University
-
Won Jin-hee
College Of Oriental Medicine Wonkwang University
-
Shin Jo-young
College Of Oriental Medicine Wonkwang University
-
Kim Tae-gyun
College Of Oriental Medicine Wonkwang University
-
Chung Hwan-suck
Department Of Pharmacology College Of Oriental Medicine Kyung Hee University:department Of Oriental
-
Chung Hwan-suck
College Of Pharmacy Wonkwang University
-
Seo S‐b
Department Of Pharmacology College Of Oriental Medicine Kyung Hee University:department Of Oriental
-
Seo Sang
Department Of Herbology College Of Oriental Medicine Wonkwang University
-
Ahn Kyoo-seok
Department Of Pathology College Of Oriental Medicine Kyung Hee University
-
Kim Hyung‐min
Dep. Of Anatomy School Of Medicine Chonbuk National Univ.
-
Kim Hyung-ryong
Dep. Of Dental Pharmacology And Wonkwang Biomaterial Implant Res. Inst. School Of Dentistry Wonkwang
-
Kim H.
韓国
-
Kim H‐m
Yonsei Univ. School Of Medicine
-
Chung Hwan-suck
College Of Pharmacy Vestibulocochlear Research Center Of Wonkwang University
-
Jung Hyun-ju
Coll. Of Pharmacy And Wonkwang-oriental Medicines Res. Inst. Wonkwang Univ.
-
Jung H‐a
Coll. Of Oriental Medicine And Inst. Of Oriental Medicine Kyung Hee Univ.
-
Na Ho‐jeong
Dep. Of Pharmacology Coll. Of Oriental Medicine Inst. Of Oriental Medicine Kyung Hee Univ.
-
Kim Hong‐joon
Department Of Veterinary Medicine College Of Life Sciences Research Institute For Subtropical Agricu
-
Chung Hwan-suck
Dep. Of Pathology Coll. Of Oriental Medicine Kyung Hee Univ.
-
Jeong Hyun-Ja
Department of Botanical Resources, Sangji University
-
Seo Sang-Wan
Department of Herbology, College of Oriental Medicine, Wonkwang University
関連論文
- The Genome-Wide Expression Profile of Nelumbinis semen on Lipopolysaccharide-Stimulated BV-2 Microglial Cells
- Decursin Prevents Cisplatin-Induced Apoptosis via the Enhancement of Antioxidant Enzymes in Human Renal Epithelial Cells
- ウシ網膜におけるプロテインキナーゼCの発現に関する免疫組織化学的研究(解剖学)
- Differential expression and localization of connexins 26 and 43 in the rat gingival epithelium
- Microarray Analysis on Odontogenesis-related-genes in Mouse Dental Papillae(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
- Anti-inflammatory Effect of Columbianetin on Activated Human Mast Cells
- Hwanggunchungyitang Prevents Cadmium-Induced Ototoxicity through Suppression of the Activation of Caspase-9 and Extracellular Signal-Related Kinase in Auditory HEI-OC1 Cells(Pharmacology)
- The Anti-inflammatory Effect of Gigukjiwhangwhangami through the Inhibition of Nuclear Factor-κB Activation in the Peripheral Blood Mononuclear Cells of Patients with Cerebral Infarction(Pharmacognosy)
- Anti-inflammatory Activity of Gumiganghwaltang through the Inhibition of Nuclear Factor-κB Activation in Peritoneal Macrophages(Pharmacology)
- Immune-Enhancing Effect of the Korean Natural Medicine WooKiEum(Pharmacology)
- Regulatory Effect of Dosiinpartner on High-Fat Diet-Induced Obesity in C57BL/6J Mice(Pharmacology)
- Induction of Nitric Oxide Synthase by Oldenlandia diffusa in Mouse Peritoneal Macrophages
- Effect of Ionizing Radiation on the Differentiation of ROS 17/2.8 Osteoblasts through Free Radicals
- The Anti-gastropathic and Anti-rheumatic Effect of Niga-ichigoside F_1 and 23-Hydroxytormentic Acid Isolated from the Unripe Fruits of Rubus coreanus in a Rat Model(Pharmacognosy)
- β-D-Xylopyranosyl-(1→3)-β-D-glucuronopyranosyl Echinocystic Acid Isolated from the Roots of Codonopsis lanceolata Induces Caspase-Dependent Apoptosis in Human Acute Promyelocytic Leukemia HL-60 Cells(Pharmacognosy)
- 19α-Hydroxyursane-Type Triterpenoids : Antinociceptive Anti-inflammatory Principles of the Roots of Rosa rugosa(Pharmacognosy)
- Methanol Extract of Xanthium strumarium L. Possesses Anti-inflammatory and Anti-nociceptive Activities(Pharmacognosy)
- Structure-Activity Relationship of Oleanane Disaccharides Isolated from Akebia quinata versus Cytotoxicity against Cancer Cells and NO Inhibition (Pharmacognosy)
- Antinociceptive and Antiinflammatory Effects of Niga-ichigoside F_1 and 23-Hydroxytormentic Acid Obtained from Rubus coreanus(Pharmacognosy)
- Inhibition of Methanol Extract from the Aerial Parts of Saururus chinensis on Lipopolysaccharide-Induced Nitric Oxide and Prostagladin E_2 Production from Murine Macrophage RAW 264.7 Cells
- ラット血管閉塞/再還流精巣におけるCD44接着分子発現(短報)(解剖学)
- Antinociceptive Anti-inflammatory Effect of Monotropein Isolated from the Root of Morinda officinalis(Pharmacognosy)
- Isolation of Saponins with the Inhibitory Effect on Nitric Oxide, Prostaglandin E_2 and Tumor Necrosis Factor-α Production from Pleurospermum kamtschaticum(Pharmacognosy)
- Molecular Authentication of Panax ginseng Species by RAPD Analysis and PCR-RFLP
- The Methylene Chloride Fraction of Trichosanthis Fructus Induces Apoptosis in U937 Cells through the Mitochondrial Pathway(Molecular and Cell Biology)
- Cyclic-AMP Inhibits Nitric Oxide-Induced Apoptosis in Human Osteoblast : The Regulation of Capase-3, -6, -9 and the Release of Cytochrome c in Nitric Oxide-Induced Apoptosis by cAMP
- The Immunosuppressive Effect of Gamisanghyulyunbueum through Inhibition of Mitogen-Activated Protein Kinase and Nuclear Factor Activation in MOLT-4 Cells(Pharmacology)
- Sargassum hemiphyllum Inhibits Atopic Allergic Reaction via the Regulation of Inflammatory Mediators
- Rubus croceacanthus Leveille Inhibits Mast Cell-Mediated Anaphylactic-Like Reaction and Tumor Necrosis Factor-α Secretion(Pharmacology)
- The Immune-Enhancing Effect of the Herbal Combination Bouum-Myunyuk-Dan(Pharmacology)
- Inhibition of Nitric Oxide and Tumor Necrosis Factor-Alpha by Moutan Cortex in Activated Mouse Peritoneal Macrophages(Pharmacognosy)
- Effect of Acori graminei Rhizoma on Contractile Dysfunction of Ischemic and Reperfused Rat Heart(Pharmacognosy)
- Inhibition of Production of Reactive Oxygen Species and Gene Expression Profile by Treatment of Ethanol Extract of Moutan Cortex Radicis in Oxidative Stressed PC12 Cells(Pharmacognosy)
- Anti-obesity Effect of PM-F2-OB, an Anti-obesity Herbal Formulation, on Rats Fed a High-Fat Diet(Pharmacognosy)
- Cambodian Phellinus linteus Inhibits Experimental Metastasis of Melanoma Cells in Mice via Regulation of Urokinase Type Plasminogen Activator(Biochemistry/Molecular Biology)
- Treatment with SI000413, a New Herbal Formula, Ameliorates Murine Collagen-Induced Arthritis(Pharmacology)
- Immunomodulatory Effect of Astragali Radix Extract on Murine Th1/Th2 Cell Lineage Development(Pharmacology)
- Inhibitory Effect of High Molecular Weight Water-Soluble Chitosan on Hypoxia-Induced Inflammatory Cytokine Production
- Oral Administration of Astragalus membranaceus Inhibits the Development of DNFB-Induced Dermatitis in NC/Nga Mice(Pharmacology)
- The 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor, Lovastatin (Statin) Ameliorates CCK-Induced Acute Pancreatitis in Rats(Pharmacology)
- Induction of Apoptosis by Korean Medicine Gagam-whanglyun-haedoktang Through Activation of Caspase-3 in Human Leukemia Cell Line, HL-60 Cells
- Ixeris dentata Green Sap Inhibits Both Compound 48/80-Induced Aanaphylaxis-Like Response and IgE-Mediated Anaphylactic Response in Murine Model
- クリップによる圧迫損傷術を施したラット脊髄におけるカテプシンDの免疫組織化学的研究(解剖学)
- ラット心臓の発達過程におけるホスホリパーゼD1の一時的発現(解剖学)
- 自己免疫性心筋炎発症Lewisラットの心組織におけるオステオポンチンの発現増強(短報)(病理学)
- クリップ圧迫により損傷したラット脊髄におけるオステオポンティンの免疫組織化学的研究(短報)(病理学)
- The Oriental Medicine 'Cool-Cool (Cool-X-A)' Inhibits Inflammatory Cytokine Production and Migration in Mast Cells(Pharmacology)
- Expression and Function of CD8 α/β Chains on Rat and Human Mast Cells (Miscellaneous)
- Protective Effects of Cuscutae semen against Dimethylnitrosamine-Induced Acute Liver Injury in Sprague-Dawley Rats(Pharmacology)
- Lithospermi radix Extract Inhibits Histamine Release and Production of Inflammatory Cytokine in Mast Cells
- OK205 Regulates Production of Inflammatory Cytokines in HMC-1 Cells(Pharmacology)
- Herbokines Increases Physical Stamina in Mice(Pharmacology)
- Periodontal Tissue Formation by Reaggregation System in Mice
- Lineage of non-cranial neural crest cell in the dental mesenchyme : using a lacZ reporter gene during early tooth development
- Analysis of tooth formation by reaggregated dental mesenchyme from mouse embryo
- SB-P4 Synthesis of post-transcriptional modulator for fine-tunable expression(Section XI Systems Biotechnology/Metabolic Engineering)
- Inactivation of cystein-aspartic acid protease (caspase)-1 by saikosaponin A
- Histone Deacetylase 1 Contributes to Cell Cycle and Apoptosis(Molecular and Cell Biology)
- Inactivation of Cystein-Aspartic Acid Protease (Caspase)-1 by Saikosaponin A
- Protective Effects of Cinnamomum cassia Blume in the Fibrogenesis of Activated HSC-T6 Cells and Dimethylnitrosamine-Induced Acute Liver Injury in SD Rats
- Lithospermi radix Extract Inhibits Histamine Release and Production of Inflammatory Cytokine in Mast Cells
- Leuconostoc citreum HJ-P4 (KACC 91035) regulates immunoglobulin E in an ovalbumin-induced allergy model and induces interleukin-12 through nuclear factor-kappa B and p38/c-Jun N-terminal kinases signaling in macrophages
- Improvement of Atopic Dermatitis-Like Skin Lesions by Platycodon grandiflorum Fermented by Lactobacillus plantarum in NC/Nga Mice
- Ursolic Acid from Oldenlandia diffusa Induces Apoptosis via Activation of Caspases and Phosphorylation of Glycogen Synthase Kinase 3 Beta in SK-OV-3 Ovarian Cancer Cells
- Erratum: Treatment with SI000413, a New Herbal Formula, Ameliorates Murine Collagen-Induced Arthritis [Biol. Pharm. Bull. 31(7): 1337—1342]