Immunomodulatory Effect of Astragali Radix Extract on Murine Th1/Th2 Cell Lineage Development(Pharmacology)
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概要
- 論文の詳細を見る
Astragali Radix (AR), is a popular herbal medicine used to treat allergic diseases in Korea, Japan and China. Our study examined the effect of an AR ethanol extract on both in vitro and in vivo murine CD4 T cells' differentiation into Th1 and Th2 subsets. CD4 T cells from Balb/c mice were activated with anti-CD3/anti-CD28 mAb in the presence of AR for 2 d. AR treated cells showed an elevated level of IL-4 but a reduced level of IFN-γ secretion. In addition, in vitro Th1/Th2 polarization experiments revealed that AR enhanced the levels of IL-4 in Th2 cells but reduced the levels of IFN-γ in Th1 cells. To elucidate the effects of AR in Th1/Th2 lineage development during the in vivo condition, AR was administrated orally to BALB/c mice. The results demonstrated that AR administration significantly increased IL-4 production in both the serum and supernatant of splenocyte culture, while IFN-γ secretion was diminished upon in vivo activation with anti-CD3 antibody. Our data clearly indicates that AR selectively alters Th1/Th2 cytokine secretion patterns and provides the pharmacological basis for AR's clinical applications.
- 社団法人日本薬学会の論文
- 2004-12-01
著者
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AHN Kyoo-Seok
Department of Food and Nutrition, Chung-Ang University
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Kang Hee
Department Of Dermatology Ajou University School Of Medicine
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CHO Chongwoon
Purimed R&D Institute, Kyung Hee University
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Ahn Kyoo-seok
Department Of Pathology College Of Oriental Medicine Kyunghee University
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BAE Hyun-Su
Department of Physiology, College of Oriental Medicine, KyungHee University
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Bae Hyun-su
Department Of Physiology College Of Oriental Medicine Kyunghee University
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Kang Hee
Department Of Applied Physics Osaka University:department Of Physics Sciences Chungbuk National Univ
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Cho Chongwoon
Purimed R&d Institute Kyung Hee University
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