Inhibition of Nitric Oxide and Tumor Necrosis Factor-Alpha by Moutan Cortex in Activated Mouse Peritoneal Macrophages(Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
Moutan cortex (MC) is one of the most widely used Oriental herbal medicines for treating inflammatory diseases. In this study, the effect of MC on lipopolysaccharide (LPS) and recombinant interferon-gamma (rIFN-γ)-induced production of nitric oxide (NO) and tumor necrosis factor (TNF)-alpha were examined using mouse peritoneal macrophages. MC inhibited the LPS/rIFN-γ-induced expression of inducible nitric oxide synthase (iNOS) and TNF-alpha release. To clarify the mechanism involved, the effect of MC on the activation of nuclear factor (NF)-kappaB was examined. The LPS/rIFN-γ-induced activation of NF-kappaB was almost completely blocked by MC at 0.5 mg/ml. These findings demonstrate that the inhibition of the LPS/rIFN-γ-induced production of NO and TNF-alpha by MC is due to the inhibition of NF-kappaB activation.
- 社団法人日本薬学会の論文
- 2007-05-01
著者
-
KIM Dongwoo
Department of Electrical Engineering and Computer Science, Hanyang University
-
Bae Hyunsu
Dep. Of Physiology Coll. Of Oriental Medicine Kyung Hee Univ.
-
Hong Moochang
Dep. Of Physiology Coll. Of Oriental Medicine Kyung Hee Univ.
-
CHUNG Hwan-Suck
Purimed R&D Institute, Kyung Hee University
-
KANG Moonkyu
Purimed R&D Institute, Kyung Hee University
-
CHO Chongwoon
Purimed R&D Institute, Kyung Hee University
-
PARVEZ Shoukat
Purimed R&D Institute, Kyung Hee University
-
PARK Chong-heong
Department of Internal Medicine, College of Oriental Medicine, Kyungwon University
-
OH Joonghwan
Department of Internal Medicine, College of Oriental Medicine, Kyungwon University
-
KIM Hongyeoul
Institute of Oriental Medicine, Kyung Hee University
-
SHIN Minkyu
Department of Physiology, College of Oriental Medicine, Kyung Hee University
-
HONG Moochang
Department of Physiology, College of Oriental Medicine, Kyung Hee University
-
KIM Yangseok
Department of Physiology, College of Oriental Medicine, Kyung Hee University
-
BAE Hyunsu
Purimed R&D Institute, Kyung Hee University
-
Chung Hwan-suck
Department Of Pharmacology College Of Oriental Medicine Kyung Hee University:department Of Oriental
-
Chung Hwan-suck
College Of Pharmacy Wonkwang University
-
Chung Hwan-suck
College Of Pharmacy Vestibulocochlear Research Center Of Wonkwang University
-
Kim Yangseok
Dep. Of Physiology Coll. Of Oriental Medicine Kyung Hee Univ.
-
Oh Jung-wan
Department Of Internal Medicine College Of Oriental Medicine Kyungwon University
-
Kim Dongwoo
Department Of Electrical Engineering And Computer Science Hanyang University
-
Kim Dongwoo
Department Of Internal Medicine College Of Oriental Medicine Kyungwon University
-
Shin Minkyu
Dep. Of Physiology Coll. Of Oriental Medicine Kyung Hee Univ.
-
Kim Hyunhee
College Of Oriental Medicine Kyung-hee University
-
Kang M
Purimed R&d Institute Kyung Hee University
-
Kim Hong
Institute Of Oriental Medicine Kyung Hee University
-
Cho Chongwoon
Purimed R&d Institute Kyung Hee University
-
Parvez Shoukat
Purimed R&d Institute Kyung Hee University:nibge
-
Kang Moonkyu
Purimed R&d Institute Kyung Hee University
-
Park Chong-heong
Department Of Internal Medicine College Of Oriental Medicine Kyungwon University
-
Chung Hwan-suck
Dep. Of Pathology Coll. Of Oriental Medicine Kyung Hee Univ.
-
BAE Hyunsu
Purimed R&D Institute, Kyung Hee University:Department of Physiology, College of Oriental Medicine, Kyung Hee University
-
Chung Hwan-Suck
Purimed R&D Institute, Kyung Hee University
-
Kim Dongwoo
Department of Applied Physics, Korea University, Seoul 136-713, Korea
関連論文
- The Genome-Wide Expression Profile of Nelumbinis semen on Lipopolysaccharide-Stimulated BV-2 Microglial Cells
- Outage Performance of Multi-Hop Decouple-and-Forward Relaying in Spatially Correlated MIMO Channels
- Regulatory Effect of Dosiinpartner on High-Fat Diet-Induced Obesity in C57BL/6J Mice(Pharmacology)
- Induction of Nitric Oxide Synthase by Oldenlandia diffusa in Mouse Peritoneal Macrophages
- Comparative Radio Packet Scheduling Issues in cdma2000 1x and 1xEV Systems(Wireless Communication Technologies)
- Molecular Authentication of Panax ginseng Species by RAPD Analysis and PCR-RFLP
- The Immune-Enhancing Effect of the Herbal Combination Bouum-Myunyuk-Dan(Pharmacology)
- Inhibition of Nitric Oxide and Tumor Necrosis Factor-Alpha by Moutan Cortex in Activated Mouse Peritoneal Macrophages(Pharmacognosy)
- Effects of Yukmijihwang-tang Derivatives (YMJd) on Ibotenic Acid-Induced Amnesia in the Rat(Pharmacognosy)
- Effect of Acori graminei Rhizoma on Contractile Dysfunction of Ischemic and Reperfused Rat Heart(Pharmacognosy)
- Inhibition of Production of Reactive Oxygen Species and Gene Expression Profile by Treatment of Ethanol Extract of Moutan Cortex Radicis in Oxidative Stressed PC12 Cells(Pharmacognosy)
- Effects of Yukmijihwang-tang Derivatives (YMJd), a Memory Enhancing Herbal Extract, on the Gene-Expression Profile in the Rat Hippocampus(Pharmacognosy)
- Anti-obesity Effect of PM-F2-OB, an Anti-obesity Herbal Formulation, on Rats Fed a High-Fat Diet(Pharmacognosy)
- So-Cheong-Ryong-Tang, Tradititional Korean Medicine, Suppresses Th2 Lineage Development (Pharmacognosy)
- Chung-Yeul-Gue-Soup-Sa-Gan-Tang, Traditional Korean Medicine, Enhances CD4^+ T Cell Activities and Modulates Th1/Th2 Lineage Development
- A Simple Minimum Rate Supporting Scheduler for High Speed Downlink Packet Access(Wireless Communication Technologies)
- Immunomodulatory Effect of Astragali Radix Extract on Murine Th1/Th2 Cell Lineage Development(Pharmacology)
- Inhibitory Effect of High Molecular Weight Water-Soluble Chitosan on Hypoxia-Induced Inflammatory Cytokine Production
- Outage Performance of Multi-Hop Decouple-and-Forward Relaying in Spatially Correlated MIMO Channels
- Impact of Carrier Frequency Offset on Received SNR in Dual-Hop OFDM Systems with a Fixed Relay
- Maximization of Carried Traffic by Prioritizing New Call Attempts in a CDMA Base Station with Finite Receiver Processors(Switching for Communications)
- Study of Cascade Shower Fluctuation with a Tile/Fiber Sampling Calorimeter(The Physics of Elementary Particles and Fields)
- Prioritized Call Admission Design for Providing Video Telephone Services in WCDMA Networks(Network)
- Effects of Gradual Enhancement for Receivers at Mobile Terminals in Different Locations with Greedy Scheduling(Wireless Communication Technologies)
- BER Analysis of Dual-Hop Amplify-and-Forward MIMO Relaying with Best Antenna Selection in Rayleigh Fading Channels
- Location-Dependent Downlink Capacity Loss Due to Introducing a High Data-Rate User in CDMA Cellular Systems with Multiple Low Data-Rate Users
- A Framework for Determining User Admissibility in Multiservice DS-CDMA Mobile Network Design(Special Issue on Mobile Multimedia Communications)
- Performance Comparison between Two- and Three-Phase Coded Bi-directional Relaying Protocols
- Exact and Closed-Form Outage Probability of Opportunistic Single Relay Selection in Decode-and-Forward Relaying
- The Capacity of Downlink Multiuser OFDM with Quality Based CSI Feedback
- Effect of GaN Microlens Array on Efficiency of GaN-Based Blue-Light-Emitting Diodes
- Pixel-Isolated Phase-Separated Composite Organic Film for Flexible Ferroelectric Liquid Crystal Display Applications
- Interactive Admission and Power Control Protocol for Cooperative Spectrum Underlay in Distributed Cognitive Radio Networks