Induction of Nitric Oxide Synthase by Oldenlandia diffusa in Mouse Peritoneal Macrophages
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概要
- 論文の詳細を見る
Oldenlandia diffusa (OD) has been used to treat malignant tumors. In this study using mouse peritoneal macrophages, we have examined the mechanism by which OD regulates nitric oxide (NO) production. When OD (1 mg/ml) was used in combination with 10 U/ml of recombinant interferon-γ (rlFN-γ), there was a marked cooperative induction of NO production (36.13±7.12 μ_M) by the Griess method (nitrite). Treatment of macrophages with rlFN-r plus OD (1 mg/ml) caused a significant increase in tumor necrosis factor-α(TNF-α) production (4.49±1.43 ng/ml) by enzyme-linked immunosorbent assay. The increased production of NO and TNF-α from rlFN-γ-plus OD-stimulated cells was almost completely inhibited by pretreatment with 100 μ_M of pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappa B (NF-κB). PDTC also inhibited phosphorylation of lκB in rlFN-γ-plus OD-stimulated cells. These findings demonstrate that OD increases the production of NO and TNF-α by rlFN-γ-primed macrophages and suggest that NF-κB plays a critical role in mediating these effects of OD.
- 社団法人日本薬学会の論文
- 2002-09-01
著者
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Jung Hyuk-sang
Biochip Research Center Hoseo University
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Jeong Hyun-ja
Dep. Of Anatomy School Of Medicine Chonbuk National Univ.
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Kim Hyung-Min
Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee
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Kim Sung-hoon
韓国
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Kim Su-jin
Vestibulocochlear Research Center Of Wonkwang University:college Of Oriental Medicine Kyung Hee Univ
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Hong Seung-heon
Vestibulocochlear Research Center Of Wonkwang University
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Hong S‐h
韓国
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Hong Seung-heon
韓国
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Hong Seung-heon
Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University
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Na Ho-jeong
韓国
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SONG Bong-Keun
College of Oriental Medicine, Wonkwang University
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LEE Eon-Jeong
College of Oriental Medicine, Wonkwang University
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CHUNG Hwan-Suck
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University
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JEONG Hyun-Ja
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University
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KIM Mi-Sun
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University
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KIM So-Jin
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University
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JEONG In-Seok
College of Oriental Medicine, Wonkwang University
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AHN Jong-Woong
Natural Products Research Team, Korea Research Institute of Chemical Technology
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BAEK Seung-Hwa
Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang Universi
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Kim Hyung-min
韓国
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Baek S‐h
Department Of Biochemistry And Molecular Biology College Of Medicine Yeungnam University
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Baek Suk-hwan
韓国
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Baek Seung-hwa
Department Of Herbal Resources Professional Graduate School Of Oriental Medicine Wonkwang Univerisy
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Baek Seung-hwa
韓国
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Kim Sung‐hoon
韓国
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Jung H‐s
Division In Anatomy And Developmental Biology Department Of Oral Biology College Of Dentistry Yonsei
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Kim Su-jin
Division Of Environmental Science And Technology Graduate School Of Agriculture
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Kim M‐s
Vestibulocochlear Research Center Of Wonkwang University
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Kim H‐m
Kyung Hee Univ. Seoul Kor
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Kim Hyung
College Of Oriental Medicine Kyung Hee University
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Kim Hyung-min
Department Of Pharmacology College Of Oriental Medicine Kyung Hee University
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Ahn Jong-woong
Natural Products Research Team Korea Research Institute Of Chemical Technology
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Kim Mi-sun
College Of Pharmacy Wonkwang University
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Jung Hyuk-sang
Department Of Anatomy College Of Oriental Medicine Kyung Hee University
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Na Ho‐jeong
College Of Pharmacy Wonkwang University
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KIM Sung-Hoon
Toxicology Research Center Korea Research Institute of Chemical Technology
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Chung Hwan-suck
Department Of Pharmacology College Of Oriental Medicine Kyung Hee University:department Of Oriental
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Chung Hwan-suck
College Of Pharmacy Wonkwang University
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Kim Hyung‐min
Dep. Of Anatomy School Of Medicine Chonbuk National Univ.
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Kim Hyung-ryong
Dep. Of Dental Pharmacology And Wonkwang Biomaterial Implant Res. Inst. School Of Dentistry Wonkwang
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Kim H.
韓国
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Kim H‐m
Yonsei Univ. School Of Medicine
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Chung Hwan-suck
College Of Pharmacy Vestibulocochlear Research Center Of Wonkwang University
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Kim Seung-ae
Cancer Preventive Material Dev. Res. Center Coll. Of Oriental Medicine Kyunghee Univ.
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Kim Sung-hoon
Coll. Of Oriental Medicine Kyung Hee Univ.
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So Hong-seob
韓国
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Song Bong-keun
Vestibulocochlear Research Center Of Wonkwang University
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Lee Eon-jeong
College Of Oriental Medicine Wonkwang University
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Jung H‐a
Coll. Of Oriental Medicine And Inst. Of Oriental Medicine Kyung Hee Univ.
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Na Ho‐jeong
Dep. Of Pharmacology Coll. Of Oriental Medicine Inst. Of Oriental Medicine Kyung Hee Univ.
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Kim Hong‐joon
Department Of Veterinary Medicine College Of Life Sciences Research Institute For Subtropical Agricu
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Jeong In-seok
College Of Oriental Medicine Wonkwang University
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Kim Mi-sun
Department Of Dermatology Seoul National University College Of Medicine
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Shin H‐y
Kyung Hee Univ. Seoul Kor
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Chung Hwan-suck
Dep. Of Pathology Coll. Of Oriental Medicine Kyung Hee Univ.
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Jeong Hyun-Ja
Department of Botanical Resources, Sangji University
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