PERI- AND POSTNATAL STUDY (SEGMENT III) OF RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTORS (LBD-005) IN RATS
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概要
- 論文の詳細を見る
A perinatal and postnatal study was carried out in Sprague-Dawley rats subcutaneously injected recombinant Granulocyte-Macrophage Colony Stimulating Factors (LBD-005), the growth of stem cell and the development of the hematopoietic cell, at dose levels of 250, 500 and 1000 μg/kg/day for a period from day 17 of gestation to day 21 after delivery. All pregnant dams were allowed to litter naturally, and the postnatal development of the offsprings was observed. The incidences of external, internal and skeletal anomalies were not significantly increased in the F_1 and F_2 fetuses of any treated groups. Recombinant GM-CSF caused no effects on parturition, lactation, postnatal growth and differentiation, behaviour and reproductive ability of the male and female offsprings.
- 日本トキシコロジー学会の論文
著者
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Kim Sung-hoon
韓国
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Kim Su-jin
Vestibulocochlear Research Center Of Wonkwang University:college Of Oriental Medicine Kyung Hee Univ
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Han Sang-seop
韓国
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Kim Sung‐hoon
韓国
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Kim Su-jin
Division Of Environmental Science And Technology Graduate School Of Agriculture
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Han S‐s
Pharmacokinetics & Toxicokinetics Lab. Toxicology Research Center Korea Research Institute Of Ch
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Han Sang-seop
Toxicology Research Center Korea Research Institute Of Chemical Technology
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Roh J‐k
Pharmacokinetics And Toxicokinetics Lab. Toxicology Research Center Korea Research Institute Of Chem
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KIM Sung-Hoon
Toxicology Research Center Korea Research Institute of Chemical Technology
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CHUNG Moon-Koo
Toxicology Research Center Korea Research Institute of Chemical Technology
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ROH Jung-Koo
Toxicology Research Center Korea Research Institute of Chemical Technology
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Kim Seung-ae
Cancer Preventive Material Dev. Res. Center Coll. Of Oriental Medicine Kyunghee Univ.
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Chung Moon-koo
Pharmacokinetics & Toxicokinetics Lab. Toxicology Research Center Korea Research Institute Of Ch
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Chung Moon-koo
Toxicol.res.ctr. Korea Research Institute Of Chemical Technology
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Kim Sung-hoon
Coll. Of Oriental Medicine Kyung Hee Univ.
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Han Sang-seop
Toxicol.res.ctr. Korea Research Institute Of Chemical Technology
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