Cambodian Phellinus linteus Inhibits Experimental Metastasis of Melanoma Cells in Mice via Regulation of Urokinase Type Plasminogen Activator(Biochemistry/Molecular Biology)

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概要

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• Phellinus linteus (PL) is a fungus mainly found in tropical America, Africa and Asian countries including Korea, Japan and China. PL has been traditionally used for the treatment of arthritis, liver damage and cancer. However, little was known on the biological activity and characterization of Phellinus species in Cambodia. Thus, in the present study, the anti-metastatic mechanism of aqueous extract of Cambodian Phellinus linteus (CPL) was evaluated. Cambodian mushroom was identified as a Phellinus species with 99% homology of Phellinus linteus by DNA sequence analysis and comparison by the National Center for Biotechnology Information. CPL did not exhibit any significant cytotoxicity against B16BL6 cells, invasive melanoma cells at 1 mg/ml. However, CPL inhibited platelet aggregation induced by B16BL6 cells and also disrupted the adhesion to gelatin and invasion of B16BL6 cells in a concentration dependent manner. Similarly, CPL dose-dependently inhibited the pulmonary metastatic colonies in C57BL/6 mice intravenously injected by B16BL6 cells up to 55.5% at a dose of 50 mg/kg compared with untreated control. CPL also down-regulated the expression of urokinase type plasminogen activator (uPA), one of key proteins associated with invasion and metastasis of tumor cells in a concentration dependent fashion, while CPL didn't significantly affect the expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) by reverse transcriptase-polymerase chain reaction (RT-PCR). Taken together, these findings indicate that Cambodian Phellinus linteus may inhibit metastasis at least partly via regulation of uPA associated with tumor cell induced platelet aggregation (TCIPA) and also suggest a further study for isolation of active ingredients and the involvement of adhesion molecule signaling pathway.

• 社団法人日本薬学会の論文
• 2005-01-01

著者

• Kim Hyung-min

  College Of Oriental Medicine Kyung Hee University

• Jeong Hyun-ja

  Dep. Of Anatomy School Of Medicine Chonbuk National Univ.

• Kim Sung-hoon

  韓国

• Kim Su-jin

  Vestibulocochlear Research Center Of Wonkwang University:college Of Oriental Medicine Kyung Hee Univ

• Na Ho-jeong

  韓国

• Lee Eun-ok

  Coll. Of Oriental Medicine Kyung Hee Univ.

• Kim Hyung-min

  韓国

• KIM Sung-Hoon

  Department of Oncology, Graduate School of East-West Medical Science

• Kim Sung‐hoon

  韓国

• Jung H‐s

  Division In Anatomy And Developmental Biology Department Of Oral Biology College Of Dentistry Yonsei

• Kim Su-jin

  Division Of Environmental Science And Technology Graduate School Of Agriculture

• Kim H‐m

  Kyung Hee Univ. Seoul Kor

• Kim Hyung

  College Of Oriental Medicine Kyung Hee University

• Lee Hong-beom

  Division Of Ocean Science Korea Maritime University

• Jung Hyuk-sang

  Department Of Anatomy College Of Oriental Medicine Kyung Hee University

• Na Ho‐jeong

  College Of Pharmacy Wonkwang University

• Ahn K

  Korea Research Institute Of Bioscience And Biotechnology

• KIM Sung-Hoon

  Toxicology Research Center Korea Research Institute of Chemical Technology

• Ahn K‐s

  Cancer Preventive Material Development Research Center College Of Oriental Medicine Kyunghee Univers

• Ahn Kwang

  Cancer Preventive Material Dev. Res. Center Coll. Of Oriental Medicine Kyunghee Univ.

• KIM Dae-Keun

  College of Pharmacy, Woosuk University

• LEE Hyo-Jung

  Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University

• LEE Hyo-Jeong

  Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University

• LIM Eu-Soo

  Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University

• AHN Kyoo-Seok

  College of Oriental Medicine, Kyunghee University

• SHIM Beom-Sang

  College of Oriental Medicine, Kyunghee University

• GONG Soo-Ja

  Chosun Nursing College

• KIM Dae-Keun

  Collge of Pharmacy, Woosuk University

• Kim Hyung‐min

  Dep. Of Anatomy School Of Medicine Chonbuk National Univ.

• Kim Hyung-ryong

  Dep. Of Dental Pharmacology And Wonkwang Biomaterial Implant Res. Inst. School Of Dentistry Wonkwang

• Kim H.

  韓国

• Kim H‐m

  Yonsei Univ. School Of Medicine

• Kim Dae

  Coll. Of Pharmacy Woosuk Univ.

• Kim Dae-keun

  College Of Pharmacy Woosuk University

• Kim Seung-ae

  Cancer Preventive Material Dev. Res. Center Coll. Of Oriental Medicine Kyunghee Univ.

• Lee Hyo-jung

  Coll. Of Oriental Medicine Kyung Hee Univ.

• Shim Beom-sang

  College Of Oriental Medicine Kyunghee University

• Kim Sung-hoon

  Coll. Of Oriental Medicine Kyung Hee Univ.

• Na Ho‐jeong

  韓国

• Ahn K

  Seoul National Univ. Seoul Kor

• Jung H‐a

  Coll. Of Oriental Medicine And Inst. Of Oriental Medicine Kyung Hee Univ.

• Na Ho‐jeong

  Dep. Of Pharmacology Coll. Of Oriental Medicine Inst. Of Oriental Medicine Kyung Hee Univ.

• Kim Sung-hoon

  Department Of Chemistry Konkuk University

• Kim Hong‐joon

  Department Of Veterinary Medicine College Of Life Sciences Research Institute For Subtropical Agricu

• Lee Hyo-jeong

  Department Of Complementary And Alternative Therapy College Of Management Commerce And Social Welfar

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