Structure-Activity Relationships of Lignans from Schisandra chinensis as Platelet Activating Factor Antagonists
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概要
- 論文の詳細を見る
We studied the structure-activity relationships of lignans from Schisandra chinensis and their derivatives as platelet activating factor (PAF) antagonists. Strong activity was shown in lignans without an ester group at C-6,a hydroxyl group at C-7 or a methylene dioxy moiety and with an R-biphenyl configuration. 6(7)-Dehydroschisandrol A, a derivative of schisandrol A, showed the highest activity (IC_<50>, 2.1×10^<-6> M) in this study.
- 社団法人日本薬学会の論文
- 1999-03-15
著者
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Kinjo Junei
熊本大学 薬
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Lee Hyeong-kyu
韓国
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Lee Hyeong-kyu
Korea Research Institute Of Bioscience And Biotechnology
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Lee Im
Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog
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Ahn K
Korea Research Institute Of Bioscience And Biotechnology
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LEE Im
Biotechnology Research Division, Korea Research Institute of Bioscience and Biotechnology
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JUNG Keun
Biotechnology Research Division, Korea Research Institute of Bioscience and Biotechnology
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OH Sei
Biotechnology Research Division, Korea Research Institute of Bioscience and Biotechnology
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PARK Si
Biotechnology Research Division, Korea Research Institute of Bioscience and Biotechnology
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AHN Kyung
Biotechnology Research Division, Korea Research Institute of Bioscience and Biotechnology
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LEE Hyeong-Kyu
Biotechnology Research Division, Korea Research Institute of Bioscience and Biotechnology
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Park Si-hyung
Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog
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Ahn K‐s
Cancer Preventive Material Development Research Center College Of Oriental Medicine Kyunghee Univers
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Ahn Kwang
Cancer Preventive Material Dev. Res. Center Coll. Of Oriental Medicine Kyunghee Univ.
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Jung K
Korea Res. Inst. Biosci. And Biotechnol. Taejon Kor
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Lee Hyeong-kyu
Korea Res. Inst. Of Bioscience And Biotechnology
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Lee Hyeong-kyu
Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog
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Oh Sei-ryang
Korea Research Institute Of Bioscience And Biotechnology:college Of Pharmacy Wonkwang University
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Ahn K
Seoul National Univ. Seoul Kor
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Lee I
Korea Res. Inst. Biosci. And Biotechnol. Taejon Kor
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