Examination for Estrogenic Activities of Soyasaponin I and Related Compounds
スポンサーリンク
概要
- 論文の詳細を見る
The estrogenic activities, i.e., i) the binding ability to human estrogen receptors (hERs) a and β ii) the effect on hER-dependent β-galactosidase induction, and iii) the effect on the estrogen-dependent growth of MCF-7 cells, of soybean saponin [soyasaponin 1 (1)] and related compounds [soyasapogenol B (3) and its monoglucuronide (2)] were investigated, since the amount of saponins in soybean is more than that of isoflavones which are known as phytoestrogen. The estrogenic activities of soybean saponins and related compounds were less than those of isoflavones. The binding and β-galactosidase-inducive behavior of compounds 1-3 was similar to that of tamoxifen which is known as an estrogen antagonist. However, their antagonistic activity was far less potent than that of tamoxifen. Contrary to the antagonistic activity, compounds 1 - 3 inhibited hER-dependent growth of MCF-7 cells. Especially, the sapogenol (3) showed anti-proliferative activity (IC_<50> < 1μM) against MCF-7 cells.
- 日本生薬学会の論文
- 2004-10-20
著者
-
Nagamatsu T
Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University
-
Nagao T
Laboratory Of Pharmacobiology And Theraperutics Faculty Of Pharmaceutical Science Meijo University
-
Nagao Toshiyuki
Department Of Pharmacology Faculty Of Pharmacy Meijo University
-
Nagamatsu T
Department Of Pharmacology Faculty Of Pharmacy Meijo University
-
岡部 光
Faculty Of Pharmaceutical Sciences Fukuoka University
-
TSUCHIHASHI Ryota
Faculty of Pharmaceutical Sciences, Fukuoka University
-
Kinjo Junei
Faculty Of Pharmaceutical Sciences Fukuoka University
-
Kinjo Junei
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Fukuoka University
-
Hirakawa Tomoki
Faculty Of Pharmaceutical Sciences Kumamoto University
-
Hirakawa Tomoki
福岡大学 薬
-
MORITO Keiko
Faculty of Pharmaceutical Sciences, Kanazawa University
-
Tsuchihashi Ryota
Faculty Of Pharmaceutical Sciences Fukuoka University
-
Okabe Hikaru
Faculty Of Pharmaceutical Sciences Fukuoka University
-
岡部 光
福岡大学
-
Okabe Hikaru
福岡大学 薬学部
-
岡部 光
福岡大学薬学部
-
金城 順英
熊本大学 薬
-
Morito Keiko
Faculty Of Pharmaceutical Sciences Kanazawa University
-
Aomori Tohru
Faculty Of Pharmaceutical Sciences Kanazawa University
-
Kim J-h
Faculty Of Pharmaceutical Sciences Fukuoka University
-
Jung K
Korea Res. Inst. Biosci. And Biotechnol. Taejon Kor
-
Nohara Toshihiro
Faculty Of Medical And Pharmaceutical Science Kumamoto University
-
Masamune Y
Department Of Microbiology Faculty Of Pharmaceutical Sciences Kanazawa University
-
Masamune Yukito
Faculty Of Pharmaceutical Sciences Kanazawa University
-
Hirose Toshiharu
Faculty Of Pharmaceutical Sciences Kanazawa University
-
Matsumoto Yumiko
Department Of Hygienic Sciences Kobe Pharmaceutical University
-
Miyata Yoshiaki
Graduate School Of Natural Science And Technology Kanazawa University
-
Kinjyo Junei
Faculty Of Pharmaceutical Sciences Kumamoto University
-
Masamune Y
Faculty Of Pharmaceutical Sciences Kanazawa University
-
Okawa Masafumi
Faculty Of Pharmaceutical Sciences Fukuoka University
-
Nohara Toshihiro
Faculty of Medical and Pharmaceutical Scieces, Sojo University
関連論文
- Protective Effect of Prostaglandin EP_4-Receptor Agonist on Anti-glomerular Basement Membrane Antibody-Associated Nephritis
- Microbial transformation and bioactivation of isoflavones from Pueraria flowers by human intestinal bacterial strains
- Cyclodextrin-Enclosed Substances of Brazilian Propolis
- Two Novel Long-Chain Alkanoic Acid Esters of Lupeol from Alecrim-Propolis
- Flavonoids from Brazilian Propolis
- A new diterpenoid and a new triterpenoid glucosyl ester from the leaves of Callicarpa japonica Thunb. var. luxurians Rehd.
- A new lignan glucoside from the stems of Callicarpa japonica Thunb. var. luxurians Rehd.
- Five New Diterpenoids, Viteagnusins A-E, from the Fruit of Vitex agnus-castus
- A new phenylethanoid glycoside from the fruits of Callicarpa japonica Thunb. var. luxurians Rehd.
- Two New 15, 16-Seco-cycloartane Glycosides from Cimicifuga Rhizome
- Four New Cycloartane Glycosides from Aquilegia vulgaris and Their Immunosuppressive Activities in Mouse Allogeneic Mixed Lymphocyte Reaction
- Three Cycloartane Glycosides from Cimicifuga Rhizome and Their Immunosuppressive Activities in Mouse Allogeneic Mixed Lymphocyte Reaction
- Studies on the Constituents of Gueldenstaedtia multiflora
- Three New Monoterpenoids from the Fruit of Genipa americana
- Four New Triterpene Glycosides from Nigella damascena
- New Iridoid Glucosides from the Aerial Parts of Verbena brasiliensis
- ウスバサイシンAsiasarum sieboldii F. Maekawaの発芽特性
- Anti-herpes Virus Type 1 Activity of Oleanane-Type Triterpenoids(Pharmacognosy)
- New Bisabolane-Type Sesquiterpenes from the Aerial Parts of Lippia dulcis
- Examination for Estrogenic Activities of Soyasaponin I and Related Compounds
- A New Lignan Glycoside and Phenylethanoid Glycosides from Strobilanthes cusia BREMEK
- Soy Isoflavone Metabolites Isolated from Human Urine
- Pregnane- and Furostane-Type Oligoglycosides from the Seeds of Allium tuberosum
- Steroids from the Underground Parts of Trillium kamtschaticum
- Hepatoprotective Constituents in Plants 14. Effects of Soyasapogenol B, Sophoradiol, and Their Glucuronides on the Cytotoxicity of tert-Butyl Hydroperoxide to HepG2 Cells(Pharmacognosy)
- Four New Cycloartane Glycosides from Aquilegia vulgaris
- Sesquiterpenoids, Triterpenoids, and Flavonoids from the Fruits of Schinus molle
- DPPH radical-scavenging effect on some constituents from the aerial parts of Lippia triphylla
- Two new lignan glucosides from the fruit of Vitex cannabifolia
- Two Novel Antioxidant Ortho-Benzoyloxyphenyl Acetic Acid Derivatives from the Fruit of Vaccinium uliginosum
- Two New Steroid Glycosides and a New Sesquiterpenoid Glycoside from the Underground Parts of Trillium kamtschaticum
- Iridoid Glucosides from the Fruit of Genipa americana
- Antioxidative, Antihyaluronidase and Antityrosinase Activities of Some Constituents from the Aerial Part of Piper elongatum VAHL.
- Evaluation of the Anti-oxidative Effect (in vitro) of Tea Polyphenols(Organic Chemistry)
- Antiproliferative Activity of the Main Constituents from Phyllanthus emblica
- Effects of KD3-671, an Angiotensin II Type 1 Receptor Antagonist, on Anti-Thy-1 Nephritis in Rats
- Involvement of Prostaglandin E_2 in Clearance of Aggregated Protein via Protein Kinase A in Glomeruli
- Thromboxane A_2 Interferes with a Disposal Process of Aggregated Protein in Glomeruli
- Effect of DP - 1904, a Thromboxane A_2 Synthase Inhibitor, Administered from the Autologous Phase on Crescentic-Type Anti-GBM Nephritis in Rats
- ピオグリタゾンは肥満型糖尿病の腎症を改善させる--腎臓の酸化反応を緩和する
- Insufficient Expression of Cyclooxygenase-2 Protein Is Associated With Retarded Degradation of Aggregated Protein in Diabetic Glomeruli
- Increase in the Deposition of Aggregated Protein in the Glomeruli of Spontaneously Diabetic Mice
- Three New Acyclic Diterpene Glycosides from the Aerial Parts of Paprika and Pimiento
- Acyclic Diterpene Glycosides, Capsianosides C,D,E,F and III, from the Fruits of Hot Red Pepper Capsicum annuum L. Used in Kimchi and Their Revised Structures
- Studies on the chemical constituents of green leaves of Eucommia ulmoides Oliv.
- Physiological functions of solanaceous and tomato steroidal glycosides
- Acyclic Diterpene Glycosides, Capsianosides VIII, IX, X, XIII, XV and XVI from the Fruits of Paprika Capsicum annuum L. var. grossum BAILEY and Jalapeno Capsicum annuum L. var. annuum
- P-229 NEW STEROIDAL GLYCOSIDES FROM TUBOCAPSICUM ANOMALUM
- Tomato New Sapogenols : Isoesculeogenin A and Esculeogenin B
- Acteoside, a Component of Stachys Sieboldii MIQ, May Be a Promising Antinephritic Agent(3): Effect of Acteoside on Expression of Intercellular Adhesion Molecule-1 in Experimental Nephritic Glomeruli in Rats and Cultured Endothelial Cells
- Suppression of Experimental Crescentic-Type Anti-Glomerular Basement Membrane (GBM) Nephritis by FK506 (Tacrolimus Hydrate) in Rats
- The Possible Roles of Hyperlipidemia and Mononuclear Cells in Glomeruli in Puromycin Aminonucleoside Nephrosis in Rats
- PRECLINICAL EVALUATION OF ANTINEPHRITIC DRUGS
- Pharmacological Studies on Experimental Nephritic Rats-9-Changes in Activities of Urinary Enzymes in the Modified Type of Masugi′s Nephritis and Their Sources
- Pharmacological studies on experimental nephritic rats-2-Antinephritic effect of various drugs on Masugi′s nephritis
- Antiproteinuric Effect of KD3-671, an Angiotensin II Type 1 Receptor Antagonist, in Rats With Accelerated Passive Heymann Nephritis
- Microbial metabolism of soy isoflavones by human intestinal bacterial strains
- Two New Cycloartane Glycosides from the Underground Parts of Aquilegia vulgaris
- A New Steroidal Glycoside and a New Phenyl Glycoside from a Ripe Cherry Tomato
- New C_ Steroidal Glycosides from Tubocapsicum anomalum
- A New Homostilbene and Two New Homoisoflavones from the Bulbs of Scilla scilloides
- Mechanism for Conversion of Spirosolane Derivative into Pregnane
- A Pregnane Glycoside from Overripe Tomato
- Two Labdane Diterpene and Megastigmane Glycosides from Aquilegia hybrida
- Conversion of Esculeoside A into Esculeogenin B
- Antiproliferative Constituents from Umbelliferae Plants VII. Active Triterpenes and Rosmarinic Acid from Centella asiatica(Pharmacognosy)
- Three New Steroid Glycosides from the Underground Parts of Trillium kamtschaticum
- Three New 15,16-Seco-cycloartane Glycosides from Cimicifuga Rhizome
- New C_ Steroidal Glycosides from Tubocapsicum anomalum
- Two New 15-Deoxycimigenol-Type and Three New 24-epi-Cimigenol-Type Glycosides from Cimicifuga Rhizome
- Steroidal Alkaloid Glycosides, Esculeosides C and D, from the Ripe Fruit of Cherry Tomato
- Interactions of Phytoestrogens with Estrogen Receptors α and β(III). Estrogenic Activities of Soy Isoflavone Aglycones and Their Metabolites Isolated from Human Urine(Toxicology)
- Efficient Conversion of Tomatidine into Neuritogenic Pregnane Derivative
- Metabolism of Tomato Steroidal Glycosides in Humans
- P-297 ANTI-FOAM CELL FORMATION OF ESCULEOGENIN A, A NOVEL STEROIDAL ALKALOID ISOLATED FROM TOMATO
- P-263 NOVEL TOMATO STEROIDAL GLYCOSIDES
- Cytotoxic Triterpenes and Sterol from the Fruit of Rabbiteye Blueberry (Vaccinium ashei)
- Induction of Cyclooxygenase-2 Expression in Glomeruli by Aggregated Protein
- Cytotoxic Activity of Steroidal Glycosides from Solanum Plants(Pharmacognosy)
- Modulation of Anti-Glomerular Basement Membrane Nephritis in Rats by ONO-1301, a Non-Prostanoid Prostaglandin I_2 Mimetic Compound with Inhibitory Activity against Thromboxane A_2 Synthase
- Distinction of Absolute Configuration at C-22 of C-23-Hydroxyspirostane and C-23-Hydroxyspirosolane Glycosides
- P-276 ANTIOBESITY EFFECTS OF GREEN LEAVES OF EUCOMMIA AND THEIR CHEMICAL CONSTITUENTS
- Antiproliferative Constituents from Umbelliferae Plants. IX. New Triterpenoid Glycosides from the Fruits of Bupleurum rotundifolium
- Antiproliferative Constituents from Umbelliferae Plants VI. New Ursane-Type Saikosaponin Analogs from the Fruits of Bupleunim rotundifolium
- Three Unusual 22-β-O-23-Hydroxy-(5α)-spirostanol Glycosides from the Fruits of Solanum torvum
- Two New Tetranor-Cycloartane Glycosides from Cimicifuga Rhizome
- Cucurbitane Glycosides from Unripe Fruits of Siraitia grosvenori
- Cucurbitane Glycosides from Unripe Fruits of Lo Han Kuo (Siraitia grosvenori)
- Steroidal Glycosides from the Underground Parts of Solanum sodomaeum
- Three new aromatic glycosides from the ripe fruit of cherry tomato
- Simultaneous analysis of isoflavones and saponins in Pueraria flowers using HPLC coupled to an evaporative light scattering detector and isolation of a new isoflavone diglucoside
- Study of constituents of Veronicastrum villosulum
- Examination for Estrogenic Activities of Soyasaponin I and Related Compounds
- Soy Isoflavone Metabolites Isolated from Human Urine
- HPLC Profile Analysis of Hepatoprotective Oleanene-Glucuronides in Several Soybean Processed Foods
- Components of convolvulin from Quamoclit×multifida
- Content variations of the tomato saponin esculeoside A in various processed tomatoes
- Study of the chemical constituents of Pruni Cortex and its related parts
- 糸球体における凝集タンパクの分解処理とCREBのリン酸化へのProtein kinase Cの関与
- 糸球体における凝集タンパクの分解処理とCREBのリン酸化へのProtein kinase Cの関与