Anti-herpes Virus Type 1 Activity of Oleanane-Type Triterpenoids(Pharmacognosy)
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概要
- 論文の詳細を見る
The anti-herpes simplex virus type 1 (HSV-1) activity of 15 oleanan-type triterpenoides including glycyrrhizin and its sapogenol was examined and their structure-activity relationships were discussed. Although glycyrrhizin which exhibited in vivo efficacy against HSV-1 replication showed moderate in vitro anti-HSV-1 activity, its sapogenol, glycyrrhetic acid, showed 10 times greater action than glycyrrhizin. Therefore, the in vivo anti-HSV-1 activity of glycyrrhizin administered orally could be reasonably attributed to glycyrrhetic acid generated by hydrolysis by intestinal bacteria. Since the activity of soyasapogenol A was less than 1/20 of that of soyasapogenol B, the hydroxylation at C-21 seemed to reduce anti-HSV-1 activity. Since kudzusapogenol A, abrisapogenols B and C lacked the activity, the C-29 hydroxy group would eliminate anti-HSV-1 activity. On the other hand, since the methylesters of kudzusapogenol B and glycyrrhetic acid exhibited greater action, a methoxy carboxy group at C-20 might enhance activity.
- 社団法人日本薬学会の論文
- 2005-09-01
著者
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Okawa Masafumi
Faculty of Pharmaceutical Sciences, Fukuoka University
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Yokomizo Kazumi
Laboratory of Presymptomatic Medical Pharmacology, Faculty of Pharmaceutical Sciences, Sojo Universi
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Nagamatsu T
Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University
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Nagao Toshiyuki
名城大学 薬学部臨床疾患制御学
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Nagao Toshiyuki
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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Nagamatsu T
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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TSUCHIHASHI Ryota
Faculty of Pharmaceutical Sciences, Fukuoka University
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KINJO Junei
Faculty of Pharmaceutical Sciences, Fukuoka University
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Kinjo Junei
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kinjo Junei
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Fukuoka University
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Kinjo Junei
福岡大学 薬学部
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Kinjo Junei
熊本大学 薬
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IKEDA Tsuyoshi
Laboratory of Natural Medicines, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
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NOHARA Toshihiro
Laboratory of Natural Medicines, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
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UYEDA Masaru
Laboratory of Pharmaceutical Microbiology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto
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Tsuchihashi Ryota
Faculty Of Pharmaceutical Sciences Fukuoka University
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Uyeda Masaru
Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un
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Uyeda Masaru
Shokei University
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金城 順英
熊本大学 薬
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Nohara Toshihiro
Fac. Of Pharmaceutical Sciences Sojo Univ.
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Yokomizo K
Kumamoto Univ. Kumamoto Jpn
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Ikeda Tsuyoshi
Faculty Of Medical And Pharmaceutical Sciences Kumamoto University
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Udayama M
Kumamoto Univ. Kumamoto Jpn
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Yokomizo Kazumi
Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un
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Yokomizo Kazumi
Faculty Of Pharmaceutical Sciences Kumamoto University
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Uyeda Masaru
Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University
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Kinjo J
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kim J-h
Faculty Of Pharmaceutical Sciences Fukuoka University
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Jung K
Korea Res. Inst. Biosci. And Biotechnol. Taejon Kor
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Nohara Toshihiro
Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University
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Udayama Manabu
Faculty Of Pharmaceutical Sciences Kumamoto University
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Uyeda Masaru
Department Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un
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Nagao T
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kinjyo Junei
Faculty Of Pharmaceutical Sciences Kumamoto University
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Okawa Masafumi
Faculty Of Pharmaceutical Sciences Fukuoka University
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