Trypanocidal Constituents in Plants 5. Evaluation of Some Mexican Plants for Their Trypanocidal Activity and Active Constituents in the Seeds of Persea americana(Pharmacognosy)
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概要
- 論文の詳細を見る
Crude extracts of Mexican medicinal plants were screened for trypanocidal activity against Trypanosoma cruzi, which is the etiological agent for Chagas' disease, one of the most serious protozoan diseases in Latin America. There were 71 kinds of methanolic and other organic extracts from 65 plants, which were newly examined by a preliminary screening test to observe immobilization of epimastigotes and trypomastigotes of T. cruzi in vitro. The MeOH extract of seeds of Persea americana (avocado) showed moderate activity against epimastigotes. In order to identify the principal compounds for the activity, the MeOH extract was subjected to bioassay-guided fractionation. From the active fractions, six 1,2,4-trihydroxyheptadecane derivatives and two 1,2,4-trihydroxy-nonadecane derivatives including a new one were isolated. These compounds showed moderate activity against epimastigotes and trypomastigotes.
- 社団法人日本薬学会の論文
- 2005-07-01
著者
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Okawa Masafumi
Faculty of Pharmaceutical Sciences, Fukuoka University
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阿部 フミ子
Faculty Of Pharmaceutical Sciences Fukuoka University
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赤羽 啓栄
福岡医大
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赤羽 啓栄
School Of Medicine Fukuoka University
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赤羽 啓栄
九州大学 寄生虫
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赤羽 啓栄
信州大・志賀高原生研
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赤羽 啓栄
福岡大学 病理学
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KINJO Junei
Faculty of Pharmaceutical Sciences, Fukuoka University
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Kinjo Junei
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kinjo Junei
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Fukuoka University
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Kinjo Junei
福岡大学 薬学部
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Kinjo Junei
熊本大学 薬
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Okawa Masafumi
東海大学 農学部
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ABE Fumiko
Faculty of Pharmaceutical Sciences, Fukuoka University
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NAGAFUJI Shinya
Faculty of Pharmaceutical Sciences, Fukuoka University
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AKAHANE Hiroshige
School of Medicine, Fukuoka University
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OGURA Tetsuya
Department of Chemistry, CEN, Universidad Autonoma de Guadalajara
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MARTINEZ ALFARO
Jardin Botanico del Instituto de Biologia, Ciudad Universitaria
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REYES CHILPA
Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria
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金城 順英
熊本大学 薬
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Akahane H
School Of Medicine Fukuoka University
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赤羽 啓栄
福岡大医
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Abe Fumiko
Faculty Of Pharmaceutical Science Fukuoka University
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Reyes Chilpa
Instituto De Quimica Universidad Nacional Autonoma De Mexico Ciudad Universitaria
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Kinjo J
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kim J-h
Faculty Of Pharmaceutical Sciences Fukuoka University
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Jung K
Korea Res. Inst. Biosci. And Biotechnol. Taejon Kor
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Martinez Alfaro
Jardin Botanico Del Instituto De Biologia Ciudad Universitaria
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Nagafuji Shinya
Faculty Of Pharmaceutical Sciences Fukuoka University
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Akahane Hiroshige
福岡大学医学部寄生虫学
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Kinjyo Junei
Faculty Of Pharmaceutical Sciences Kumamoto University
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Ogura Tetsuya
Departamento De Quimica Cen Universidad Autonoma De Guadalajara Apdo.
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Ogura Tetsuya
Department Of Chemistry Cen Universidad Autonoma De Guadalajara
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赤羽 啓栄
福岡大学 医学部 寄生虫学 教室
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Okawa Masafumi
Faculty Of Pharmaceutical Sciences Fukuoka University
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OGURA Tetsuya
Departamento de Quìmica, CEN, Universidad Autónoma de Guadalajara Apdo
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