Trypanocidal Constituents in Plants 2. Xanthones from the Stem Bark of Garcinia subelliptica (Pharmacognosy)

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概要

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• The constituents of the stem bark of Garcinia subelliptica (Guttiferae) were investigated based on its trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent for Chagas' disease. As the active components, nine xanthones were isolated including two new ones, 4-hydroxybrasilixanthone B and 1,3,5,6-tetrahydroxy-4,7,8-tri(3-methyl-2-butenyl)xanthone. Their structures were determined by spectroscopic analysis. Trypanocidal activity against trypomastigotes, an infectious form of T. cruzi, was also estimated as well as cytotoxic activity. Fukugetin, the major component of the bark, showed no activity.

• 公益社団法人日本薬学会の論文
• 2003-12-01

著者

• 岡部 光

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 阿部 フミ子

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 赤羽 啓栄

  福岡医大

• 赤羽 啓栄

  School Of Medicine Fukuoka University

• 赤羽 啓栄

  九州大学 寄生虫

• 赤羽 啓栄

  信州大・志賀高原生研

• 赤羽 啓栄

  福岡大学 病理学

• ABE Fumiko

  Faculty of Pharmaceutical Sciences, Fukuoka University

• NAGAFUJI Shinya

  Faculty of Pharmaceutical Sciences, Fukuoka University

• OKABE Hikaru

  Faculty of Pharmaceutical Sciences, Fukuoka University

• AKAHANE Hiroshige

  School of Medicine, Fukuoka University

• Okabe Hikaru

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 岡部 光

  福岡大学

• Okabe Hikaru

  福岡大学 薬学部

• 岡部 光

  福岡大学薬学部

• Akahane H

  School Of Medicine Fukuoka University

• 赤羽 啓栄

  福岡大医

• Abe Fumiko

  Faculty Of Pharmaceutical Science Fukuoka University

• HIGO Hiroo

  Graduate School of Medical Sciences, Kyushu University

• Nagafuji Shinya

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Akahane Hiroshige

  福岡大学医学部寄生虫学

• Higo H

  Graduate School Of Medical Sciences Kyushu University

• 赤羽 啓栄

  福岡大学 医学部 寄生虫学 教室

• Abe Fumio

  Faculty of Pharmaceutical Sciences, Fukuoka University

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