Antiproliferative Constituents in Umbelliferae Plants. III. Constituents in the Root and the Ground Part of Anthriscus sylvestris HOFFM.
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概要
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The MeOH extract of the root and the ground part of Anthriscus sylvestris HOFFM. showed a high inhibitory activity against MK-1,HeLa, and B16F10 cell growth in vitro. The activity was found only in the CHCl_3-soluble fractions. From the CHCl_3-soluble fraction of the root, falcarindiol, 1-(3'-methoxy-4', 5'-methylenedioxyphenyl)-1ξ-methoxy-2propene, elemicin, and nemerosin were newly isolated in addition to deoxypodophyllotoxin (anthricin), anthriscusin, (-)-deoxypodorhizone, and anthriscinol methyl ether which were reported earlier as constituents of the root of this plant.From the CHCl_3-soluble fraction of the ground part, deoxypodophyllotoxin, (-)-deoxypodorhizone, nemerosin, and falcarindiol were isolated.In vitro antiproliferative activities of the isolates against MK-1,HeLa, and B16F10 cells are reported.
- 社団法人日本薬学会の論文
- 1998-05-15
著者
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岡部 光
Faculty Of Pharmaceutical Sciences Fukuoka University
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Katano Mitsuo
Department Of Surgery Saga Medical School
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Katano Mitsuo
Department Of Cancer Therapy And Research Graduate School Of Medical Sciences Kyushu University
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Mori Masao
Faculty Of Hospital Pharmacy Saga Medical School
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OKABE Hikaru
Faculty of Pharmaceutical Sciences, Fukuoka University
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NAGAO Tsuneatsu
Faculty of Pharmaceutical Sciences, Fukuoka University
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Okabe Hikaru
Faculty Of Pharmaceutical Sciences Fukuoka University
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岡部 光
福岡大学
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Okabe Hikaru
福岡大学 薬学部
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岡部 光
福岡大学薬学部
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Katano M
Department Of Surgery Saga Medical School
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Ikeda Ryuji
Faculty Of Pharmaceutical Sciences Fukuoka University
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Mori M
Department Of Pharmacy Saga University Hospital
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Mori M
Faculty Of Hospital Pharmacy Saga Medical School
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Mori M
The Institute Of Physical And Chemical Research (riken)
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NAKANO Yukitaka
Faculty of Hospital Pharmacy, Saga Medical School
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MATSUNAGA Hisashi
Faculty of Hospital Pharmacy, Saga Medical School
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MORI Masato
Faculty of Hospital Pharmacy, Saga Medical School
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森 昌斗
Hospital Pharmacy Saga Medical School
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Nagao Tsuneatsu
Faculty Of Pharmaceutical Sciences Fukuoka University
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Matsunaga H
Takeda Chemical Ind. Ltd. Osaka Jpn
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Nakano Yukitaka
Faculty Of Hospital Pharmacy Saga Medical School
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Matsunaga H
Dep. Of Pharmacy Okayama Univ. Hospital
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