Antiproliferative Constituents from Umbelliferae Plants. V. A New Furanocoumarin and Falcarindiol Furanocoumarin Ethers from the Root of Angelica japonica

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概要

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• The CHCl_3 extract of the root of Angelica japonica showed high inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth. From this extract, a new furanocoumarin named japoangelone and four furanocoumarin ethers of falcarindiol, named japoangelols A-D, were isolated together with caffeic acid methyl ester, four polyacetylenic compounds (panaxynol, falcarindiol, 8-O-acetylfalcarindiol, and (9Z)-1,9-heptadecadiene-4,6-diyne-3,8,11-triol), eight coumarins (osthol, isoimperatorin, scopoletin, byakangelicin, xanthotoxin, bergapten, oxypeucedanin methanolate, and oxypeucedanin hydrate), and two chromones (3'-O-acetylhamaudol, and hamaudol). The structures of the new isolates were determined based on spectral evidence. The ED_<50> of isolates against MK-1,HeLa, and B16F10 cell lines are reported.

• 社団法人日本薬学会の論文
• 1999-01-15

著者

• 岡部 光

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Katano Mitsuo

  Department Of Surgery Saga Medical School

• Katano Mitsuo

  Department Of Cancer Therapy And Research Graduate School Of Medical Sciences Kyushu University

• Mori Masao

  Faculty Of Hospital Pharmacy Saga Medical School

• Matsunaga Keiji

  Graduate School Of Pharmaceutical Sciences Kyoto University

• OKABE Hikaru

  Faculty of Pharmaceutical Sciences, Fukuoka University

• FUJIOKA Toshihiro

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Okabe Hikaru

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 岡部 光

  福岡大学

• Okabe Hikaru

  福岡大学 薬学部

• 岡部 光

  福岡大学薬学部

• Katano M

  Department Of Surgery Saga Medical School

• Fujii Hiroko

  Faculty Of Pharmaceutical Sciences Fukitoka University

• Mori M

  Department Of Pharmacy Saga University Hospital

• Mori M

  Faculty Of Hospital Pharmacy Saga Medical School

• Mori M

  The Institute Of Physical And Chemical Research (riken)

• FURUMI Kazuhiro

  Faculty of Pharmaceutical Sciences, Fukuoka University

• MIHASHI Kunihide

  Faculty of Pharmaceutical Sciences, Fukuoka University

• NAKANO Yukitaka

  Faculty of Hospital Pharmacy, Saga Medical School

• MATSUNAGA Hisashi

  Faculty of Hospital Pharmacy, Saga Medical School

• MORI Masato

  Faculty of Hospital Pharmacy, Saga Medical School

• FUJII Hisashi

  Kanagawa Industrial Technology Research Institute

• Matsunaga K

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 森 昌斗

  Hospital Pharmacy Saga Medical School

• Fujii H

  Kanagawa Industrial Technology Research Institute

• Fujioka T

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Fujioka Toshihiro

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Matsunaga H

  Takeda Chemical Ind. Ltd. Osaka Jpn

• Furumi Kazuhiro

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Nakano Yukitaka

  Faculty Of Hospital Pharmacy Saga Medical School

• Mihashi Kunihide

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Matsunaga H

  Dep. Of Pharmacy Okayama Univ. Hospital

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