Inhibitory Effects of Cucurbitane Triterpenoids on Epstein-Barr Virus Activation and Two-Stage Carcinogenesis of Skin Tumor. II

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概要

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• To search for possible anti-tumor-promoters, we carried out a primary screening of twenty-four 29-nor-cucurbitacin glucosides isolated from the roots of Cayaponia tayuya (Cucurbitaceae) using an in vitro synergistic assay system. Of these glucosides, cayaponosides B (5), B_3 (7), D (8), D_<3b>(22) and C_2 (23) exhibited significant inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Furthermore, 5 and 23 exhibited remarkable anti-tumor-promoting effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.

• 公益社団法人日本薬学会の論文
• 1995-02-15

著者

• 長尾 常敦

  福岡大

• 岡部 光

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 徳田 春邦

  京府医大

• 木島 孝夫

  Kyoto Pharmaceutical University

• 高崎 みどり

  Kyoto Pharmaceutical University

• 小塚 睦夫

  Kyoto Pharmaceutical University

• 徳田 春邦

  京都府立医科大学生化学教室

• 西野 輔翼

  京都府立医科大学 院 分子生化学

• 西野 輔翼

  Cancer Prevention Division, National Cancer Center Research Institute

• 岡部 光

  福岡大学

• Okabe Hikaru

  福岡大学 薬学部

• 岡部 光

  福岡大学薬学部

• 徳田 春邦

  Department of Biochemistry, Kyoto Prefectural University of Medicine

• 加藤 昌子

  Div. Of Chemistry Fac. And Graduate School Of Sci. Hokkaido Univ.

• 長尾 常敦

  Faculty of Pharmaceutical Sciences, Fukuoka University

• 真岡 孝至

  Kyoto Pharmaceutical University

• 入野 信人

  Nippon Mektron, Ltd.

• 中隅 哲郎

  Institute de Pesouisas de Plantas Medicinais do Brazil

• 西野 輔翼

  Cancer Prevention Division National Cancer Center Research Institute

• 入野 信人

  Nippon Mektron Ltd.

• 徳田 春邦

  京都府立医大・第一内科

• Maoka T

  Sun Biorex Co. Ltd. Kyoto Jpn

• 小塚 睦夫

  Kyoto Pharmaceutical Univ. Kyoto Jpn

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