Antiproliferative Constituents in the Plants 7. Leaves of Clerodendron bungei and Leaves and Bark of C. trichotomum^<1)>
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概要
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The constituents of the leaves of Clerodendron bungei STEUD. (Verbenaceae) and leaves and bark of C. trichotomum THUNB. were investigated guided by the antiproliferative activity against three tumor cell lines (MK-1: human gastric adenocarcinoma, HeLa: human uterus carcinoma, and B16F10: murine melanoma). Two phenylethanoid glycoside caffeic acid esters, acteoside and isoacteoside, were isolated as the constiuents which selectively inhibit the growth of B16F10 cells. The antiproliferative activities against B16F10 cells of acteoside (GI_<50>: 8μM), isoacteoside (8μM) and their methanolysis products, methyl caffeate (26μM), 3, 4-dihydroxyphenethyl alcohol (8μM), 3, 4-dihydroxyphenethyl glucoside (10μM), desrhamnosyl acteoside (6μM), and desrhamnosyl isoacteoside (6μM) suggested that the 3, 4-dihydroxyphenethyl alcohol group might be more responsible for the activities of acteoside and isoacteoside than the caffeoyl group. The activities of chlorogenic acid, 3, 4-dihydroxyphenylacetic acid, 3-(3, 4-dihydroxyphenyl) alanine, 3, 4-dihydroxy-phenethylamine hydrochloride, ferulic acid, sinapic acid, and five dihydroxybenzoic acids were also determined and compared with those of the above compounds.
- 公益社団法人日本薬学会の論文
- 2001-11-01
著者
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Nagao Toshiyuki
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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岡部 光
Faculty Of Pharmaceutical Sciences Fukuoka University
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阿部 フミ子
Faculty Of Pharmaceutical Sciences Fukuoka University
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ABE Fumiko
Faculty of Pharmaceutical Sciences, Fukuoka University
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OKABE Hikaru
Faculty of Pharmaceutical Sciences, Fukuoka University
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NAGAO Tsuneatsu
Faculty of Pharmaceutical Sciences, Fukuoka University
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Okabe Hikaru
Faculty Of Pharmaceutical Sciences Fukuoka University
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岡部 光
福岡大学
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Okabe Hikaru
福岡大学 薬学部
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岡部 光
福岡大学薬学部
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Abe Fumiko
Faculty Of Pharmaceutical Science Fukuoka University
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Nagao T
Faculty Of Pharmaceutical Sciences Fukuoka University
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Nagao Tsuneatsu
Faculty Of Pharmaceutical Sciences Fukuoka University
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