Antiproliferative Constituents from Umbelliferae Plants. IX. New Triterpenoid Glycosides from the Fruits of Bupleurum rotundifolium
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概要
- 論文の詳細を見る
The MeOH extract of the fruits of Bupleurum rotundifolium showed inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth. Bioactivity-guided fractionation of the MeOH extract led to the isolation of four new triglycosides of 13β, 28-epoxy oleanane-type triterpenes, named rotundiosides O, Q, S and T; 12 new glycosides of oleanane-type triterpenes, named rotundiosides J-N, P, R, U-Y, and others; echinocystic acid 3-O-sulfate; and three known oleanane-type triterpene glycosides, rotundiosides A, F and G. The structures of the new isolates were determined based on chemical and spectroscopic evidence. The GI_<50> of isolates against MK-1, HeLa and B16F10 cell lines are reported.
- 公益社団法人日本薬学会の論文
- 2006-12-01
著者
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Nagamatsu T
Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University
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Nagao Toshiyuki
名城大学 薬学部臨床疾患制御学
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Nagao Toshiyuki
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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Nagamatsu T
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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岡部 光
Faculty Of Pharmaceutical Sciences Fukuoka University
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Matsunaga Keiji
Graduate School Of Pharmaceutical Sciences Kyoto University
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Nohara T
Faculty Of Pharmaceutical Sciences Kumamoto University
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OKABE Hikaru
Faculty of Pharmaceutical Sciences, Fukuoka University
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NAGAO Tsuneatsu
Faculty of Pharmaceutical Sciences, Fukuoka University
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FUJIOKA Toshihiro
Faculty of Pharmaceutical Sciences, Fukuoka University
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YOSHIDA Miyako
Faculty of Pharmaceutical Sciences, Fukuoka University
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Okabe Hikaru
Faculty Of Pharmaceutical Sciences Fukuoka University
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岡部 光
福岡大学
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Okabe Hikaru
福岡大学 薬学部
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岡部 光
福岡大学薬学部
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Nohara Toshihiro
Fac. Of Pharmaceutical Sciences Sojo Univ.
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Takata Jiro
Laboratory Of Drug Design And Drug Delivery Faculty Of Pharmaceutical Sciences Fukuoka University
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MIHASHI Kunihide
Faculty of Pharmaceutical Sciences, Fukuoka University
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IWASE Yukiko
Faculty of Pharmaceutical Sciences, Fukuoka University
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MATSUNAGA Kazuhisa
Faculty of Pharmaceutical Sciences, Fukuoka University
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TAKATA Jiro
Faculty of Pharmaceutical Sciences, Fukuoka University
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KARUBE Yoshiharu
Faculty of Pharmaceutical Sciences, Fukuoka University
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Nishiyama T
Laboratory Animal Center Taisho Pharmaceutical Co. Ltd.
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Karube Yoshiharu
Faculty Of Pharmaceutical Sciences Fukuoka University
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Matsunaga Kazuhisa
Faculty Of Pharmaceutical Sciences Fukuoka University
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Nagao T
Faculty Of Pharmaceutical Sciences Fukuoka University
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YOSHIDA Keisuke
Faculty of Pharmaceutical Sciences, Fukuoka University
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SHIBAO Hiroko
Faculty of Pharmaceutical Sciences, Fukuoka University
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Matsunaga K
Faculty Of Pharmaceutical Sciences Fukuoka University
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Takata Jiro
Faculty Of Pharmaceutical Sciences Fukuoka University
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Iwase Y
Faculty Of Pharmaceutical Sciences Fukuoka University
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Iwase Yukiko
Fac. Of Pharmaceutical Sciences Fukuoka Univ.
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Iwase Yukiko
Faculty Of Pharmaceutical Sciences Fukuoka University
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Shibao Hiroko
Faculty Of Pharmaceutical Sciences Fukuoka University
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Yoshida M
Faculty Of Pharmaceutical Sciences Fukuoka University
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Yoshida Miyako
Faculty Of Pharmaceutical Sciences Fukuoka University
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Matsunami Katsuyoshi
Department Of Pharmacognosy Graduate School Biomedical Sciences Hiroshima University
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Fujioka T
Faculty Of Pharmaceutical Sciences Fukuoka University
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Fujioka Toshihiro
Faculty Of Pharmaceutical Sciences Fukuoka University
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Nagao Tsuneatsu
Faculty Of Pharmaceutical Sciences Fukuoka University
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Yoshida Keisuke
Faculty Of Mechanical Engineering Kyushu University
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Mihashi Kunihide
Faculty Of Pharmaceutical Sciences Fukuoka University
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