Antiproteinuric Effect of KD3-671, an Angiotensin II Type 1 Receptor Antagonist, in Rats With Accelerated Passive Heymann Nephritis
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概要
- 論文の詳細を見る
The antiproteinuric effect of KD3-671 (2-propyl-8-oxo-1-[(2-(H-tetrazole-5-yl)biphenyl-4-yl)methyl]-4,5,6,7-tetrahydrocycloheptimidazole), an angiotensin II type 1 receptor antagonist, was compared with that of enalapril, an angiotensin II-converting enzyme inhibitor, using an experimental model of membranous nephropathy. KD3-671 (3, 10 and 30 mg/kg per day) and enalapril (30 mg/kg per day) were given p.o. for 40 days, respectively. KD3-671 (30 mg/kg per day) inhibited the elevation of proteinuria and plasma total cholesterol. On the other hand, enalapril showed only a tendency to diminish these parameters. KD3-671 had an antiproteinuric effect in rats with accelerated passive Heymann nephritis. These findings provide considerable encouragement for the clinical development of KD3-671.
- 社団法人 日本薬理学会の論文
- 2002-02-01
著者
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Nagamatsu T
Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University
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Nagamatsu Tadashi
名城大学 薬学部薬理学
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Nagamatsu Tadashi
Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University
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Nagao T
Laboratory Of Pharmacobiology And Theraperutics Faculty Of Pharmaceutical Science Meijo University
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Nagao Toshiyuki
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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Nagamatsu T
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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Suzuki Y
School Of Pharmaceutical Sciences University Of Shizuoka
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Suzuki Y
Fukuoka Inst. Technol. Fukuoka
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SUZUKI Yoshio
Department of Pharmacology, Faculty of Pharmacy, Meijo University
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Suzuki Y
Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University
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Suzuki Y
Core Research For Evolutional Science And Technology (crest Jst) University Of Shizuoka School Of Ph
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HAYASHI Kazumi
Department of Pharmacology, Faculty of Pharmacy, Meijo University
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Hayashi Kazumi
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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Suzuki Yoshio
Department Of Electronics Fukuoka Institute Of Technology
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Suzuki Y
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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Suzuki Yoshio
Department Of Chemical Science & Technology Faculty Of Engineering Kyushu University
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