PHARMACOLOGICAL STUDIES ON EXPERIMENTAL NEPHRITIC RATS (9). CHANGES IN ACTIVITIES OF URINARY ENZYMES IN THE MODIFIED TYPE OF MASUGIS NEPHRITIS AND THEIR SOURCES
スポンサーリンク
概要
- 論文の詳細を見る
Using a modified model of Masugis nephritis of rats, various enzymatic activities in urine, serum and renal tissue (glomeruli or cortex) were determined at appropriate intervals after the administration of anti-kidney serum and compared with the urinary protein content and the kidney weight. In the urine, alkaline phosphatase (Al-Phosase), acid phosphatase (Ac-Phosase) and N-acetyl-β-glucosaminidase (NA-β-Gase) activities remarkably increased after the induction of nephritis, reached their peaks on the 10th day and reverted to almost the normal levels on the 30th day. The patterns of time course of these enzymatic activities were similar to patterns seen in the urinary protein content and the kidney weight. In the serum, the Al-Phosase activity decreased slightly, while NA-β-Gase activity increased slightly. The AcPhosase activity in serum remained at normal levels during the experimental periods. In the glomeruli, the bound activities of these three enzymes decreased with nephritis, showing a negative correlation with results in the urine. On the other hand, fibrinolytic activities in the urine (plasmin-like enzyme) and renal cortex (plasminogen activator) also paralleled the urinary protein content and the kidney weight in the course of the disease. These results suggest that the Al-Phosase, Ac-Phosase and NA-β-Gase excreted into urine in cases of nephritis may be mostly derived from damaged renal cells and one part of Al-Phosase may also come from the plasma. Moreover, the increase of plasmin-like enzyme in urine is considered to be due to the increase of plasminogen activator in the renal cortex. Thus, the determination of these enzymatic activities in the urine should be useful for evaluating effects of drugs for the treatment of nephritis.
- 社団法人 日本薬理学会の論文
著者
-
Nagamatsu Tadashi
Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University
-
Suzuki Y
Core Research For Evolutional Science And Technology (crest Jst) University Of Shizuoka School Of Ph
-
Ito Mikio
Department Of Materials Science And Processing Graduate School Of Engineering Osaka University
-
Suzuki Yoshio
Department Of Electronics Fukuoka Institute Of Technology
-
Suzuki Yoshio
Department Of Chemical Science & Technology Faculty Of Engineering Kyushu University
-
Ito Mikio
Department Of Analytical Pharmacology Faculty Of Pharmacy Meijo University
-
ITO Mikio
Department of Pharmacology, Faculty of Pharmacy, Meijo University
関連論文
- Protective Effect of Prostaglandin EP_4-Receptor Agonist on Anti-glomerular Basement Membrane Antibody-Associated Nephritis
- Identification and Characterization of Carbohydrate Molecules in Mammalian Cells Recognized by Dengue Virus Type 2
- A Unique Phosphatidylinositol Bearing a Novel Branched-Chain Fatty Acid from Rhodococcus equi Binds to Influenza Virus Hemagglutinin and Inhibits the Infection of Cells
- lnhibitory action of sulfatide a putative ligand for L-selectiv on B cell proliferation and lg prodrction
- Microstructure and Thermoelectric Properties of NaxCo2O4 Synthesized by Spark Plasma Sintering (特集 熱電変換材料)
- Effect of Partical Substitution of 3d Transition Metals for Co on the Thermoelectric Properties of Na_xCo_2O_4
- Preparation of SiC Dispersed Fe_Co_Si_2 by Pressureless Sintering with Cu and Si Addition and Its Thermoelectric Performance
- 液相焼結法によるβ-FeSi_2の作製とその熱電特性
- Effects of Al and Cu Addition on Pressureless Sintering behavior and Phase Transformation of β-FeSi_2
- Effect of Si/C Ratio on thermoelectric Properties of β-FeSi_2 Mechanically Alloyed with (Si+C) Additions
- Thermoelectric Properties of β-FeSi_2 Mechanically Alloyed with Si and C
- Effects of Mechanical Alloying and Copper Addition on Thermoelectric Properties of n-Type and p-Type β-FeSi_2
- Improvement of Magnetic Properties of Mechanically Ground Sm_2Fe_N_x Powders by Vacuum Heat Treatment
- Effect of Milling Atmosphere on the Preparation of Sm_2Fe_N_x Powder by Mechanical Grinding
- Recognition of N-Glycolylneuraminic Acid Linked to Galactose by the α2,3 Linkage Is Associated with Intestinal Replication of Influenza A Virus in Ducks
- Thermodynamic Effects of Hopanoids on Synthetic and Bacterial Phospholipid Membranes
- Interactions between Bacteriohopane-32,33,34,35-tetrol and Liposomal Membranes Composed of Dipalmitoylphosphatidylcholine
- ATOMIC FORCE MICROSCOPY OF DIMYRISTOYLPHOSPHATIDYLCHOLINE MEMBRANES
- The New Role of Disodium Cromoglycate in the Treatment of Adults with Bronchial Asthma
- In Vitro Inhibition of Human Influenza A Virus Infection by Fruit-Juice Concentrate of Japanese Plum (Prunus mume SIEB. et ZUCC)(Microbiology)
- Clarithromycin Inhibits Progeny Virus Production from Human Influenza Virus-Infected Host Cells(Microbiology)
- Suppression of the Biosynthesis of Cellular Sphingolipids Results in the Inhibition of the Maturation of Influenza Virus Particles in MDCK Cells(Highlighted paper selected by Editor-in-chief,Biochemistry)
- In Vitro and in Vivo Inhibitory Effects of Disodium Cromoglycate on Influenza Virus Infection(Pharmacology)
- Duck and Human Pandemic Influenza A Viruses Retain Sialidase Activity under Low pH Conditions^1
- A Macrocyclic Sialic Acid Cluster as a Host, as an Adsorbate, and as a Ligand for Lectin and Virus
- Ganglioside GM_ on the Cell Surface Is Involved in the Infection by Human Rotavirus KUN and MO Strains
- Th1/Th2-Balancing Immunomodulating Activity of Gel-Forming(1→3)-β-Glucans from Fungi
- Adjuvant Effect of Grifolan on Antibody Production in Mice
- Effects of KD3-671, an Angiotensin II Type 1 Receptor Antagonist, on Anti-Thy-1 Nephritis in Rats
- Involvement of Prostaglandin E_2 in Clearance of Aggregated Protein via Protein Kinase A in Glomeruli
- Thromboxane A_2 Interferes with a Disposal Process of Aggregated Protein in Glomeruli
- Effect of DP - 1904, a Thromboxane A_2 Synthase Inhibitor, Administered from the Autologous Phase on Crescentic-Type Anti-GBM Nephritis in Rats
- Association study of the C3 gene with adult and childhood asthma
- Synthetic Studies on Selection Ligands/Inhibitors. Synthesis and Biological Evaluation of Sulfated and Phosphorylated β-D-Galacto- and Lactopyranosides Containing Fatty-Alkyl Residues of Different Carbon Chain Lengths
- SYNTHESIS AND BIOLOGICAL ACTIVITY OF THE NOVEL SULFATED AND PHOSPHORYLATED BIVALENT β-D-GALACTOPYRANOSIDES CONTAINING FATTY-ALKYL RESIDUES
- Influenza A Virus-Binding Activity of Glycoglycerolipids of Aquatic Bacteria
- P-564 MULTI-DIMENSIONAL HPLC MAPPING METHOD FOR STRUCTURAL ANALYSES OF N-GLYCANS AND ITS APPLICATIONS TO N-GLYCOSYLATION PROFILING OF ORGANISMS AND TISSUES
- ピオグリタゾンは肥満型糖尿病の腎症を改善させる--腎臓の酸化反応を緩和する
- Insufficient Expression of Cyclooxygenase-2 Protein Is Associated With Retarded Degradation of Aggregated Protein in Diabetic Glomeruli
- Increase in the Deposition of Aggregated Protein in the Glomeruli of Spontaneously Diabetic Mice
- Sulfatide and Its Synthetic Analogues Recognition by Moraxella catarrhalis
- β-Thujaplicin Zinc Chelate Induces Apoptosis in Mouse High Metastatic Melanoma B16BL6 Cells
- Role of Sialylglycoconjugate(s) in the Initial Phase of Metastasis of Liver-metastatic RAW117 Lymphoma Cells
- Acteoside, a Component of Stachys Sieboldii MIQ, May Be a Promising Antinephritic Agent(3): Effect of Acteoside on Expression of Intercellular Adhesion Molecule-1 in Experimental Nephritic Glomeruli in Rats and Cultured Endothelial Cells
- Suppression of Experimental Crescentic-Type Anti-Glomerular Basement Membrane (GBM) Nephritis by FK506 (Tacrolimus Hydrate) in Rats
- The Possible Roles of Hyperlipidemia and Mononuclear Cells in Glomeruli in Puromycin Aminonucleoside Nephrosis in Rats
- PRECLINICAL EVALUATION OF ANTINEPHRITIC DRUGS
- BENZYLIDENECYANOMETHYL-1,3-BENZAZOLES AS 1-AZA-1,3-BUTADIENES
- Association of the RIP2 Gene with Childhood Atopic Asthma
- Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma
- Catalytic Action of Azolium Salts. IX. Synthesis of 6-Aroyl-9H-purines and Their Analogues by Nucleophilic Aroylation Catalyzed by Imidazolium or Benzimidazolium Salt
- Carbon-Carbon Bond Cleavage of α-Hydroxybenzylheteroarenes Catalyzed by Cyanide Ion : Retro-Benzoin Condensation Affords Ketones and Heteroarenes and Benzyl Migration Affords Benzylheteroarenes and Arenecarbaldehydes
- Carbon-Carbon Bond Cleavage of α-Substituted Benzoins by Retro-Benzoin Condensation : A New Method of Synthesizing Ketones
- Catalytic Action of Azolium Salts. VIII. Oxidative Aroylation with Arenecarbaldehydes Catalyzed by 1,3-Dimethylbenzimidazolium Iodide
- A New Method of Synthesizing Deoxybenzoins from 1,3-Dimethyl-2-(α-benzyloxybenzyl)imidazolium and 1,3-Dimethyl-2-(α-benzyloxybenzyl)benzimidazolium Iodides Based on Wittig-Type Rearrangement
- Olefin-Insertion Reaction between the Carbonyls of Benzils ; Formation of 1, 4-Diketons by Michael Addition Catalyzed by Cyanide Ion
- SYNTHESIS OF KETONES BY RETRO-BENZOIN CONDENSATION CATALYZED BY POTASSIUM CYANIDE
- Antiproteinuric Effect of KD3-671, an Angiotensin II Type 1 Receptor Antagonist, in Rats With Accelerated Passive Heymann Nephritis
- An association study of asthma and related phenotypes with polymorphisms in negative regulator molecules of the TLR signaling pathway
- Induction of Cyclooxygenase-2 Expression in Glomeruli by Aggregated Protein
- Z-335,a Thromboxane A_2 Receptor Antagonist, Suppresses the Progression of Arachidonic Acid-Induced Hind Limb Gangrene in Rats
- Arachidonic Acid-Induced Hind Limb gangrene : A New Experimental Rat Model of Paripheral Vascular Disease
- New Zinc (II) Complexes with Tetradentate Amino Acid Derivatives: Structure Characterization, Solution Chemistry, and in vitro Insulinomimetic Activity
- New Insulinomimetic Zinc(II)Complexes of α-Amino Acids and Their Derivatives with Zn(N_2O_2)Coordination Mode
- Modulation of Anti-Glomerular Basement Membrane Nephritis in Rats by ONO-1301, a Non-Prostanoid Prostaglandin I_2 Mimetic Compound with Inhibitory Activity against Thromboxane A_2 Synthase
- Effects of SK-896, a New Human Motilin Analogue ([Leu^]motilin-Hse), on Postoperative Ileus in Dogs after Laparotomy
- Metabolic Fate of SK-896, a New Human Motilin Analogue ([Leu^]motilin-Hse) (III) : Feto-Placental Transfer and Excretion into Milk in Rats after Single Intravenous Injection of^3H-SK-896
- Metabolic Fate of SK-896, a New Human Motilin Analogue ([Leu^]motilin-Hse) (II) : Blood and Plasma Concentration and Excretion in Rats after Single Intravenous Injection or Constant Rate Intravenous Infusion of ^3H-SK-896
- Metabolic Fate of SK-896, a New Human Motilin Analogue ([Leu^]motilin-Hse) (I) : Distribution and Accumulation in Rats after Single or Repeated Intravenous Injection of ^3H-SK-896
- Anti-ulcer Effects of Antioxidants, Quercetin, a-Tocopherol, Nifedipine and Tetracycline in Rats
- Sex Differences in Constitutive Level of Renal Lauric Acid Hydroxylase Activities and CYP4A-Related Proteins in Mice
- Sex and Strain Differences in Constitutive Expression of Fatty Acid ω-Hydroxylase (CYP4A-Related Proteins) in Mice
- Simultaneous Evaluation of Gastric and Duodenal Ulcers-Healing Activities of Anti-ulcer Agents in Rats
- Effects of Gonadectomy and Sex Hormones on the Induction of Hepatic CYP4A by Clofibrate in Rats
- Healing-Promoting Action of the Zinc-Cimetidine Complex on Acetic Acid-Induced Gastric Ulcers in Rats
- Butein Ameliorates Experimental Anti-Glomerular Basement Membrane (GBM) Antibody-Associated Glomerulonephritis in Rats (1)
- Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population: a family and case–control study
- Studies on the Nephrotoxicity of Aminoglycoside Antibiotics and Protection from These Effects. (5). Interaction of Tobramycin with Latamoxef in Vitro
- Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus
- PHARMACOLOGICAL STUDIES ON EXPERIMENTAL NEPHRITIC RATS (9). CHANGES IN ACTIVITIES OF URINARY ENZYMES IN THE MODIFIED TYPE OF MASUGIS NEPHRITIS AND THEIR SOURCES
- PHARMACOLOGICAL STUDIES ON EXPERIMENTAL NEPHRITIC RATS (2). ANTINEPHRITIC EFFECT OF VARIOUS DRUGS ON MASUGIS NEPHRITIS
- Acteoside, a Component of Stachys Sieboldii MIQ, May Be a Promising Antinephritic Agent (2): Effect of Acteoside on Leukocyte Accumulation in the Glomeruli of Nephritic Rats
- Acteoside, a Component of Stachys Sieboldii MIQ, May Be a Promising Antinephritic Agent: Effect of Acteoside on Crescentic-Type Anti-GBM Nephritis in Rats
- Marked Antinephritic. Action and Less Adverse Effects of Methylprednisolone Suleptanate by Intermittent Administration in Rats
- Studies on the Antinephritic Effects of Plant Components (6): Antinephritic Effects and Mechanisms of Phellodendrine (OB-5) on Crescentic-Type Anti-GBM Nephritis in Rats (2)
- Studies on the Antinephritic Effect of Plant Components (4): Reduction of Protein Excretion by Berberine and Coptisine in Rats with Original-Type Anti-GBM Nephritis
- Suppression by Cyclosporin A of Anti-GBM Nephritis in Rats
- Studies on Antinephritic Effect of TJ-8014, a New Japanese Herbal Medicine (3): Effects on Crescentic-Type Anti-GBM Nephritis in Rats
- Antinephritic Effects of PGE1 and Thiaprostaglandin E1, TEI-5178 and TEI-6122, on Crescentic-Type Anti-GBM Nephritis in Rats
- Studies on Antinephritic Effect of TJ-8014, a New Japanese Herbal Medicine, and Its Mechanisms (2): Effect on the Release of Corticosterone from Adrenal Glands
- Accelerated Passive Heymann Nephritis in Rats as an Experimental Model for Membranous Glomerulonephritis and Effects of Azathioprine and Prednisolone on the Nephritis
- Antinephritic Effect of Y-19018, a Thromboxane A Synthetase Inhibitor, on Crescentic-Type Anti-GBM Nephritis in Rats
- Effects of Prostaglandin E1 and Dipyridamole on Disposal of Colloidal Carbon via Glomerular Mesangial Channels
- A genome-wide association study identifies RNF213 as the first Moyamoya disease gene
- Association of the MMP9 gene with childhood cedar pollen sensitization and pollinosis
- Replication of genetic association studies in asthma and related phenotypes
- Studies on experimental immune complex nephritis. 3. Therapeutic effect of prostaglandin E1 .ALPHA.-cyclodextrin host molecule (PGE1CD) on serum sickness nephritis in rats.
- Antinephritic effect of prostaglandin E1 on serum sickness nephritis in rats. (5). Effect of PGE1 on disposal of heat-aggregated bovine serum albumin in the glomerulus.
- Antinephritic effect of prostaglandin E1 on serum sickness nephritis in rats. (4). Enhanced clearance of macromolecules by the reticulo-endothelial system with prostaglandin E1.
- Thromboxane A2 Interferes with a Disposal Process of Aggregated Protein in Glomeruli.