New Insulinomimetic Zinc(II)Complexes of α-Amino Acids and Their Derivatives with Zn(N_2O_2)Coordination Mode

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概要

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• Zinc(II)complexes of α-amino acids and their derivatives with a Zn(N_2O_2)coordination mode were found to have in vitro insulinomimetic activity as estimated with the inhibition of free fatty acid release in isolated rat adipocytes treated with epinephrine. It was revealed that the insulinomimetic activities of zinc(II)complexes with over-all stability constants(logβ)less than 10.5 are higher than those of ZnSO_4 and VOSO_4. The high blood glucose level of KK-A^y mice with type 2 diabetes mellitus was lowered by daily intraperitoneal injections of a zinc(II)complex, cis-[Zn(L-Thr)_2(H_2O)_2], for 14d. The improvement of diabetes mellitus was confirmed with the oral glucose tolerance test.

• 公益社団法人日本薬学会の論文
• 2001-05-01

著者

• SAKURAI Hiromu

  Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University

• Suzuki Y

  School Of Pharmaceutical Sciences University Of Shizuoka

• SUZUKI Yuka

  Department of Gynecology, Aichi Cancer Center

• Suzuki Y

  Fukuoka Inst. Technol. Fukuoka

• Suzuki Y

  Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University

• Suzuki Y

  Core Research For Evolutional Science And Technology (crest Jst) University Of Shizuoka School Of Ph

• YOSHIKAWA Yutaka

  Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University

• KOJIMA Yoshitane

  Department of Chemistry, Graduate School of Science, Osaka City University

• Ueda Eriko

  Department of Chemistry, Graduate School of Science, Osaka City University

• Yanagihara Naohisa

  Department of Biosciences, Teikyo University

• Ueda Eriko

  Department Of Chemistry Graduate School Of Science Osaka City University

• Sakurai Hiromu

  Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University

• Suzuki Yuka

  Department Of Gynecology Aichi Cancer Center

• Kojima Y

  Department Of Chemistry Graduate School Of Science Osaka City University

• Kojima Yoshitane

  Department Of Chemistry Faculty Of Science Osaka City University

• Suzuki Yuka

  Department Of Functional Pharmaceutics Graduate School Of Pharmaceutical Sciences University Of Toky

• Yoshikawa Yutaka

  Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University

• Suzuki Y

  Department Of Pharmacology Faculty Of Pharmacy Meijo University

• Yanagihara N

  Department Of Biosciences Teikyo University

• Yanagihara Naohisa

  Department Of Biosciences Faculty Of Science And Engineering Teikyo University

• Ueda Eriko

  Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University

• Suzuki Yuka

  Department of Cardiology, Tokyo Women's Medical University

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