A New Diagnostic Method for Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma Based on Serum Metallothionein,Copper, and Zinc Levels

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概要

• 論文の詳細を見る

• Serum metal levels and their ratios are frequently reported to be good signals for diagnosing various diseases. These parameters are not always specific to the disease, however, it is necessary to use other serum parameters for an exact diagnosis. We examined whether the monitoring of these serum parameters such as metallothionein, copper, and zinc levels are useful in diagnosing hepatic disorders. Metallothionein levels of patients with liver cirrhosis and hepatocellular carcinoma were found to be significantly lower than those of patients with chronic hepatitis and those of controls. In contrast, copper levels of the patients with liver cirrhosis and hepatocellular carcinoma were significantly higher than those with chronic hepatitis and controls. Zinc levels of the patients with chronic hepatitis and hepatocellular carcinoma were lower than those of controls. Using these three parameters, we are introducing a new parameter, (Cu/Zn)/MT, by which we can discriminate between patients in the [control+miscellaneous diseases+chronic hepatitis] group and those in the [liver cirrhosis+hepatocellular carcinoma] group. The new parameter does not, however, allow us to clearly distinguish between the liver cirrhosis and hepatocellular carcinoma groups. Multivariate discriminant analysis was found to be very useful, with combinations of two discriminant functions having been designed to discriminate both between chronic hepatitis and liver cirrhosis and between liver cirrhosis and hepatocellular carcinoma. This method recognizes the differences between hepatic disorder, including chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma groups. On the basis of these results, we propose here that the diagnosis of hepatic disorders should be made based on a combination of three serum levels such as those of metallothionein, copper, and zinc.

• 公益社団法人日本薬学会の論文
• 2002-04-01

著者

• SAKURAI Hiromu

  Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University

• Saisho H

  Department Of Medicine And Clinical Oncology Graduate School Of Medicine Chiba University

• Nakajima Katsuyuki

  Japan Immunoresearch Laboratories Co. Ltd.

• FUKUDA Hiroyuki

  First Department of Medicine, School of Medicine, Chiba University

• EBARA Masaaki

  First Department of Medicine, School of Medicine, Chiba University

• Ebara M

  First Department Of Medicine School Of Medicine Chiba University

• Ebara Masaaki

  First Department Of Medicine Chiba University School Of Medicine

• NAKAYAMA Akihiro

  Department of Physics, Meijo University

• Hamasaki Hiroshi

  Department Of Mechanical System Engineering Faculty Of Engineering Hiroshima University

• Hamasaki Hiroshi

  Department Of Earth And Planetary Sciences Faculty Of Science Kyushu University

• Hamasaki Hiroshi

  Department Of Health Science Kyoto Pharmaceutical University

• Fukuda H

  Chiba Univ.

• Sakurai Hiromu

  Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University

• Nakayama A

  Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University

• Fukuda Hiroyuki

  Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University

• NAKAYAMA Akihiro

  Gifu Keizai University

• Nakayama Akihiro

  Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University

• Nakajima K

  Res. Inst. Of Pharmacological And Therapeutical Dev. Otsuka Pharmaceutical Co. Ltd.

• Nakajima Katsuyuki

  Japan Immunoresearch Laboratories

• Nakajima Katsuyuki

  Japan Immuno Reseach Laboratories

• NAKAYAMA Akihiro

  Department of Physics, Nagoya University

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