Scavenging Activities of α-, β- and γ-Thujaplicins against Active Oxygen Species
スポンサーリンク
概要
- 論文の詳細を見る
α-, β- and γ-Thujaplicins are three-tropolone-related compounds purified from the woods of Chamaecyparis obtusa SIEB. et ZUCC. and Thuja plicata D. DON. Based on our recent finding that β-thujaplicin inhibits the formation of sunburn cells (SBC), which appear in the epidermis after UVB irradiation, we have speculated that β-thujaplicin is a potent scavenger against active oxygen species. ESR spin-trapping, chemiluminescence and fluorescence methods, and cyclic voltammetry were used to evaluate the abilities of β-thujaplicin and its isomers, α- and γ-thujaplicins, as scavengers of five kinds of active oxygen species such as superoxide anion radicals, hydroxyl radicals, singlet oxygens, tert-butyl peroxyl radicals and hydrogen peroxides. These compounds were found to have comparable inhibitory effects of hydroxyl radicals generated by the Fenton reaction and high scavenging activities against tert-butyl peroxyl radicals as compared with those of l-ascorbic acid and dl-α-tocopherol, and α-thujaplicin was found to have the highest activity against hydrogen peroxides among the thujaplicins.However, the effects of these compounds on superoxide anion radicals and singlet oxygens were less than those of l-ascorbic acid and dl-α-tocopherol. These facts suggest that thujaplicins have effective antioxidant ability. This ability is thought to be due in part to the chelating ability and redox potential of the compounds, which in turn are related to the prevention of UV-induced photo-damage in vivo.
- 公益社団法人日本薬学会の論文
- 1997-12-15
著者
-
SAKURAI Hiromu
Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
-
Fujimoto Kaori
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaid
-
Fujimoto Kaori
Department Of Analytical And Bionorganic Chemistry Kyoto Pharmaceutical University
-
Fukuda Kohsai
Department Of Agricultural Chemistry Kyushu University:(present Address) Department Of Applied Micro
-
ARIMA Yaeno
Department of Dermatology, Kyoto University Graduate School of Medicine
-
HATANAKA Akihiko
Department of Analytical and Bionorganic Chemistry, Kyoto Pharmaceutical University
-
TSUKIHARA Sachiko
Department of Analytical and Bionorganic Chemistry, Kyoto Pharmaceutical University
-
FUKUDA Keiko
Department of Analytical and Bionorganic Chemistry, Kyoto Pharmaceutical University
-
Fukuda K
Unit Of Chemistry Faculty Of Engineering Kansai University
-
Arima Yaeno
Department Of Analytical And Bionorganic Chemistry Kyoto Pharmaceutical University
-
Fukuda Keiko
Department Of Analytical And Bionorganic Chemistry Kyoto Pharmaceutical University
-
Sakurai Hiromu
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
-
Hatanaka Akihiko
Department Of Analytical And Bionorganic Chemistry Kyoto Pharmaceutical University
-
Tsukihara Sachiko
Department Of Analytical And Bionorganic Chemistry Kyoto Pharmaceutical University
-
Hatanaka Akihiko
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
-
Sakurai Hiromu
Department Of Analytical And Bionorganic Chemistry Kyoto Pharmaceutical University
関連論文
- Mononuclear to Tetranuclear Structural Transformation in Vanadyl Complexes of 3-Hydroxypyridine-2-carboxylic Acid (H_2hpic)
- Bacampicillin Uptake Is Shared with Thiamine in Caco-2 Cells(Biopharmacy)
- Specific Inhibition by Cyclodextrins of Raw Starch Digestion by Fungal Glucoamylase
- The Hyperdigestion of Raw Starch by a Carbohydrate-Rich Glucoamylase from a Protease- and Glycosidase-Negative Mutant of Aspergillus awamori var. kawachi F-2035
- Hemagglutinating Activity of Extracellular Alkaline Metalloendopeptidases from Vibrio sp. NUF-BPP1
- Breaks in Double-Strand DNA by Cu(II) Complexes of Etoposide (VP-16) and Its Derivatives, as Evaluated by S1 Nuclease Treatment
- Human Metallothionein Gene Expression Is Upregulated by β-Thujaplicin : Possible Involvement of Protein Kinase C and Reactive Oxygen Species(Molecular and Cell Biology)
- Preparation of Optically Active Allothreonine via Optical Resolution by Replacing Crystallization
- Evaluation of Distribution Patterns for Copper and Zinc in Metallothionein and Superoxide Dismutase in Chronic Liver Diseases and Hepatocellular Carcinoma Using High-Performance Liquid Chromatography(HPLC)(Analytical Biochemistry)
- Antidiabetic Activity of Zn(II) Complexes with a Derivative of L-Glutamine
- Insulinomimetic Zinc(II) Complexes with Natural Products: In Vitro Evaluation and Blood Glucose Lowering Effect in KK-A^y Mice with Type 2 Diabetes Mellitus
- Catalytic and Spectroscopic Properties of Imidazole(N)-Fe(III)porphyrin Complexes in Dioxygenation of Tryptophan Derivatives
- Superoxide Dismutase Mimetic Complex of Mn (II)/N, N-Bis (2 - Pyridylmethyl) - (S) - Histidine
- Scavenging Activities of α-, β- and γ-Thujaplicins against Active Oxygen Species
- New Zinc (II) Complexes with Tetradentate Amino Acid Derivatives: Structure Characterization, Solution Chemistry, and in vitro Insulinomimetic Activity
- New Insulinomimetic Zinc(II)Complexes of α-Amino Acids and Their Derivatives with Zn(N_2O_2)Coordination Mode
- Four New Acridone-Coumarin Dimers from a Citrus Plant
- Selenium Supplementation Rescues Cardiac Output in Patients with Severe Heart Failure who are Intractable to ACE Inhibitors and β-Blockers(Heart Failure, Clinical 14 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- A New Physiologically Based Pharmacokinetic Analysis for In Vivo Organ Disposition of Nitroxyl Spin Probes in Mice as Measured by Multisite Detection L-band ESR (MSD-LESR)
- Role of oxidative stress on pathogenesis of hypertensive cerebrovascular lesions
- Optical Resolution by the Replacing Crystallization of DL-Threonine with L-Alanine as an Optically Active Cosolute
- Novel Extracellular Alkaline Metalloendopeptidases from Vibrio sp. NUF-BPP1 : Purification and Characterization
- Isolation and Characterization of Cytotoxic Compounds from Corn
- Relationship betweeen X- or L-Band ESR Spectra and Coordination Structures of Copper(II) Complexes with a CuO_4 Coordination Mode
- Coordination-Dependent ESR Spectra of Copper(II) Complexes with a CuN_4 Type Cooridnation Mode : Relationship between ESR Parameters and Stability Constants or Redox Potentials of the Complexes
- Oxovanadium(IV)-Porphyrin Complex as a Potent Insulin-Mimetic. Treatment of Experimental Type 1 Diabetic Mice by the Complex [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadate(IV)(4-)
- Merallokinetic Study of Zinc in the Blood of Normal Rats Given Insulinomimetic Zinc(II) Complexes and Improvement of Diabetes Mellitus in Type 2 Diabetic GK Rats by their Oral Administration
- Lysophosphatidylcholine Enhances Superoxide Anions Production via Endothelial NADH/NADPH Oxidase
- A Chemical Model of Tryptophan 2,3-Dioxygenase : Reactivity and Formation of a Reactive Intermediate in the Dioxygenation Processes
- A New Determination Method of Nitric Oxide (NO) with a NO-selective Electrode Demonstrated by the Kinetic Analysis of NO Generation and Decomposition
- Antioxidative Properties of Extracts from Ancient Rice Brans
- Novel screening method for ultraviolet protection : Combination of a human skin-equivalent model and 8-hydroxy-2'-deoxyguanosine
- Preparation of Four Geometric Isomers of 4,6-Hexadecadienol, -dienal, and -dienyl Acetate and Their Electro-Antennographic Activity toward Male Eri-Silk Moths
- Chemical Structure-Dependent Differential Effects of Flavonoids on the Catalase Activity as Evaluated by a Chemiluminescent Method(Analytical Biochemistry)
- An Improved Diagnostic Method for Chronic Hepatic Disorder : Analyses of Metallothionein Isoforms and Trace Metals in the Liver of Patients with Hepatocellular Carcinoma as Determined by Capillary Zone Electrophoresis and Inductively Coupled Plasma-Mass S
- A New Diagnostic Method for Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma Based on Serum Metallothionein,Copper, and Zinc Levels
- Synthesis, Structure, and In Vitro and In Vivo Insulinomimetic Activities of the Zinc(II)-6-Ethylpicolinate Complex
- New Bioactive Zinc(II) Complexes with Peptides and Their Derivatives : Synthesis, Structure, and In Vitro Insulinomimetic Activity
- New Insulinomimetic Zinc(II) Complexes of Nicotinamide and its Derivatives: X-ray Structure and Biochemical Activity
- Simple Procedure for Preparing Trifluoroacetylprolyl Amino Acids, Acyl Components in the Racemization Test for Peptide Synthesis by GLC(Organic Chemistry)
- A New Type of Orally Active Insulin-Mimetic Vanadyl Complex: Bis(l-oxy-2-pyridinethiolato)oxovanalum(IV)with VO(S_2O_2) Coordination Mode
- Evidence for Singlet Oxygen Involvement in Rat and Human Cytochrome P450-dependent Substrate Oxidations
- Oxovanadium (IV) and (V) Complexes with 3-Hydroxy-4(1H)-pyridinones and 1-Hydroxy-2(1H)-pyrimidinones - Synthesis, Structural Characteristics, and Their Insulin-mimetic Activities
- Insulinomimetic Vanadyl-Hydroxythiazolethione Complexes with VO(S_2O_2) Coordination Mode : The Correlation between the Activity and Hammett's Substituent Constant
- Synthesis of New Vanadyl Complexes of Hydroxyazine-type Heterocycles and Their Insulin-Mimetic Activities
- Zinc(II) complexes with allixin-derivatives as oral therapeutics for type 2 diabetes
- Insulinomimetic Activity of Vanadyl-Porphyrin Complexes
- A New Anti-diabetic Zn(II)-Hinokitiol (β-Thujaplicin) Complex with Zn(O_4) Coordination Mode
- A New Type of Orally Active Insulin-mimetic Vanadyl-porphyrin Complex : meso-Tetrakis({4-sulfonatophenyl}porphyrinato)oxovanadium(IV)
- Determination of trace element concentrations in ancient rices (red and black rices) and a present-day rice (Koshihikari) : Relationship among the trace element concentrations, species, harvest site and rice parts
- A Highly Potent Insulin-mimetic Zinc(II) Complex with a Zn(S_2O_2) Coordination Mode : Bis(1, 6-dimethyl-3-hydroxy-5-methoxy-2-pentyl-1, 4-dihydropyridine-4-thionato)zinc(II)
- Insulin-Mimetic Vanadyl (IV) Complexes as Evaluated by Both Glucose-Uptake and Inhibition of Free Fatty Acids (FFA) -Release in Isolated Rat Adipocytes
- Chemistry and Biochemistry of Insulin-Mimetic Vanadium and Zinc Complexes. Trial for Treatment of Diabetes Mellitus
- An Extremely High Insulin-Mimetic Activity of Bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridinolato)zinc(II) Complex
- Essential Role of Singlet Oxygen Species in Cytochrome P450-dependent Substrate Oxygenation by Rat Liver Microsomes
- Possible Involvement of Singlet Oxygen Species as Multiple Oxidants in P450 Catalytic Reactions
- Direct Reaction between Shikonin and Thiols Induces Apoptosis in HL60 Cells
- A zinc(II)-glycine complex is an effective inducer of metallothionein and removes oxidative stress
- A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative properties
- Dysfunction of dermal fibroblasts induced by advanced glycation end-products (AGEs) and the contribution of a nonspecific interaction with cell membrane and AGEs
- POSSIBLE ROLES OF ADVANCED GLYCATION END-PRODUCTS IN PROMOTING SKIN AGING
- Protective Effects of Baicalein against Cell Damage by Reactive Oxygen Species
- Elastin Gene Expression in Blepharochalasis
- Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes
- Structure-Activity Relationship of Insulinomimetic Activity of Zinc(II) Complexes with Pyridine-2-sulfonic Acid Derivatives
- In Vitro Alpha-glucosidase Inhibitory Effect of Zn (II) Complex with 6-Methyl-2-picolinmethylamide
- Anti-diabetes Effect of Zn (II)/Carnitine Complex by Oral Administration (Communications to the Editor)
- Differential Reactivity of Metallothionein Isoforms I and II on Active Oxygen Species
- Antioxidative Compounds in the Extracts of Black Rice Brans
- Syntheses, Structures, and Insulin-like Activities of Oxovanadium (IV) Complexes with Tetra-and Penta-dentate Histidine Derivatives
- Analyses of the Metallothioneins and Trace Metals in the Liver and Serum of the Patients with Hepatocellular Carcinoma
- Effects of X-ray Irradiation on Genomic DNA Methylation Levels in Mouse Tissues
- New Insulin-Mimetic Zinc(II)Complexes;Bis-maltolato Zinc(II)and Bis-2-hydroxypyridine-N-oxido Zinc(II)with Zn(O_4)Coordination Mode
- Syntheses, Structures, and Insulin-like Activities of Two Vanadyl Complexes;[VO(GeG)(H_2O)]and[VO(MeM)(H_2O)]
- Inhibitory Effects of Alpinia speciosa K. SCHUM on the Porphyrin Photooxidative Reaction
- Local Detection of Aluminum in Livers of Rats Treated with Aluminum-maltolate Complex
- Protective activity of hamamelitannin on cell damage of murine skin fibroblasts induced by UVB irradiation
- Comparative study of insulin-mimetic activity of vanadium and zinc complexes
- Increased generation of hydrogen peroxide possibly from mitochondrial respiratory chain after UVB irradiation of murine fibroblasts
- Superoxide Anion Scavenging Activity and Metal Contents of Coffee
- REPAIR OF OXIDATIVE DNA DAMAGE IN UVB HYPERSENSITIVE DISORDERS
- Aluminum Distribution in Organs of Animals treated with Aluminum Ion and Its Complex
- Suppressive effects of zinc compounds against UVA-induced reactive oxygen species (ROS) in the skin of hairless mice
- The physiological effects of the undercurrent water from Mt. Fuji on type 2 diabetic KK-A^y mice
- Protective effect of metallogluconates against UVA-induced cutaneous lesion in HR-1 hairless mice
- Oral Administration of Bis(aspirinato)zinc(II) Complex Ameliorates Hyperglycemia and Metabolic Syndrome-Like Disorders in Spontaneously Diabetic KK-Ay Mice: Structure–Activity Relationship on Zinc–Salicylate Complexes
- Molecular Mechanism for Antidiabetic Activity of [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadium(IV) (VO(tpps)) Complex : Studies on Akt Phosphorylation and GLUT4 Translocation in 3T3-L1 Adipocytes
- Potential Insulinominetic Agents of Zinc(II) Complexes with Picolinamide Derivatives : Preparations of Complexes, in Vitro and in Vivo Studies
- Medicinal Aspects of Vanadium Complexes : Treatment of Diabetes Mellitus in Model Animals
- Specific Binding of Vanadyl Ion (VO^) with Thiolate of the Cysteine-34 Residue in Serum Albumin, Demonstrated by CD Spectroscopy and Kinetic Property
- Evidence for the Improvement of Noninsulin-Dependent Diabetes Mellitus in KKA^y Mice with Daily Oral Administration of Bis(6-methylpicolinato)oxovanadium(IV) Complex
- Inhibitory Effect of Oxovanadium(IV), Copper(II), and Zinc(II) Ions on the Activity of an Alpha-glucosidase from a Saccharomyces sp. (特集1:若手が拓く微量元素研究の最前線)