Evidence for the Improvement of Noninsulin-Dependent Diabetes Mellitus in KKA^y Mice with Daily Oral Administration of Bis(6-methylpicolinato)oxovanadium(IV) Complex
スポンサーリンク
概要
- 論文の詳細を見る
A vanadyl complex, bis(6-methylpicolinato)oxovanadium(IV), VO(6MPA), with VO(N_2O_2) coordination mode, was found to exhibit a normoglycemic effect on KKA^y mice with hereditary noninsulin-dependent diabetes mellitus with daily oral administration.
- 公益社団法人日本薬学会の論文
- 1999-11-15
著者
-
Sakurai Hiromu
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
-
Fujisawa Y
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
-
Fujisawa Yae
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
関連論文
- Mononuclear to Tetranuclear Structural Transformation in Vanadyl Complexes of 3-Hydroxypyridine-2-carboxylic Acid (H_2hpic)
- Breaks in Double-Strand DNA by Cu(II) Complexes of Etoposide (VP-16) and Its Derivatives, as Evaluated by S1 Nuclease Treatment
- Evaluation of Distribution Patterns for Copper and Zinc in Metallothionein and Superoxide Dismutase in Chronic Liver Diseases and Hepatocellular Carcinoma Using High-Performance Liquid Chromatography(HPLC)(Analytical Biochemistry)
- Antidiabetic Activity of Zn(II) Complexes with a Derivative of L-Glutamine
- Insulinomimetic Zinc(II) Complexes with Natural Products: In Vitro Evaluation and Blood Glucose Lowering Effect in KK-A^y Mice with Type 2 Diabetes Mellitus
- Catalytic and Spectroscopic Properties of Imidazole(N)-Fe(III)porphyrin Complexes in Dioxygenation of Tryptophan Derivatives
- Superoxide Dismutase Mimetic Complex of Mn (II)/N, N-Bis (2 - Pyridylmethyl) - (S) - Histidine
- Scavenging Activities of α-, β- and γ-Thujaplicins against Active Oxygen Species
- New Zinc (II) Complexes with Tetradentate Amino Acid Derivatives: Structure Characterization, Solution Chemistry, and in vitro Insulinomimetic Activity
- New Insulinomimetic Zinc(II)Complexes of α-Amino Acids and Their Derivatives with Zn(N_2O_2)Coordination Mode
- Selenium Supplementation Rescues Cardiac Output in Patients with Severe Heart Failure who are Intractable to ACE Inhibitors and β-Blockers(Heart Failure, Clinical 14 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- A New Physiologically Based Pharmacokinetic Analysis for In Vivo Organ Disposition of Nitroxyl Spin Probes in Mice as Measured by Multisite Detection L-band ESR (MSD-LESR)
- Role of oxidative stress on pathogenesis of hypertensive cerebrovascular lesions
- Relationship betweeen X- or L-Band ESR Spectra and Coordination Structures of Copper(II) Complexes with a CuO_4 Coordination Mode
- Coordination-Dependent ESR Spectra of Copper(II) Complexes with a CuN_4 Type Cooridnation Mode : Relationship between ESR Parameters and Stability Constants or Redox Potentials of the Complexes
- Oxovanadium(IV)-Porphyrin Complex as a Potent Insulin-Mimetic. Treatment of Experimental Type 1 Diabetic Mice by the Complex [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadate(IV)(4-)
- Merallokinetic Study of Zinc in the Blood of Normal Rats Given Insulinomimetic Zinc(II) Complexes and Improvement of Diabetes Mellitus in Type 2 Diabetic GK Rats by their Oral Administration
- Lysophosphatidylcholine Enhances Superoxide Anions Production via Endothelial NADH/NADPH Oxidase
- A Chemical Model of Tryptophan 2,3-Dioxygenase : Reactivity and Formation of a Reactive Intermediate in the Dioxygenation Processes
- A New Determination Method of Nitric Oxide (NO) with a NO-selective Electrode Demonstrated by the Kinetic Analysis of NO Generation and Decomposition
- Antioxidative Properties of Extracts from Ancient Rice Brans
- Novel screening method for ultraviolet protection : Combination of a human skin-equivalent model and 8-hydroxy-2'-deoxyguanosine
- Chemical Structure-Dependent Differential Effects of Flavonoids on the Catalase Activity as Evaluated by a Chemiluminescent Method(Analytical Biochemistry)
- An Improved Diagnostic Method for Chronic Hepatic Disorder : Analyses of Metallothionein Isoforms and Trace Metals in the Liver of Patients with Hepatocellular Carcinoma as Determined by Capillary Zone Electrophoresis and Inductively Coupled Plasma-Mass S
- A New Diagnostic Method for Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma Based on Serum Metallothionein,Copper, and Zinc Levels
- Synthesis, Structure, and In Vitro and In Vivo Insulinomimetic Activities of the Zinc(II)-6-Ethylpicolinate Complex
- New Bioactive Zinc(II) Complexes with Peptides and Their Derivatives : Synthesis, Structure, and In Vitro Insulinomimetic Activity
- New Insulinomimetic Zinc(II) Complexes of Nicotinamide and its Derivatives: X-ray Structure and Biochemical Activity
- A New Type of Orally Active Insulin-Mimetic Vanadyl Complex: Bis(l-oxy-2-pyridinethiolato)oxovanalum(IV)with VO(S_2O_2) Coordination Mode
- Evidence for Singlet Oxygen Involvement in Rat and Human Cytochrome P450-dependent Substrate Oxidations
- Oxovanadium (IV) and (V) Complexes with 3-Hydroxy-4(1H)-pyridinones and 1-Hydroxy-2(1H)-pyrimidinones - Synthesis, Structural Characteristics, and Their Insulin-mimetic Activities
- Insulinomimetic Vanadyl-Hydroxythiazolethione Complexes with VO(S_2O_2) Coordination Mode : The Correlation between the Activity and Hammett's Substituent Constant
- Synthesis of New Vanadyl Complexes of Hydroxyazine-type Heterocycles and Their Insulin-Mimetic Activities
- Zinc(II) complexes with allixin-derivatives as oral therapeutics for type 2 diabetes
- Insulinomimetic Activity of Vanadyl-Porphyrin Complexes
- A New Anti-diabetic Zn(II)-Hinokitiol (β-Thujaplicin) Complex with Zn(O_4) Coordination Mode
- A New Type of Orally Active Insulin-mimetic Vanadyl-porphyrin Complex : meso-Tetrakis({4-sulfonatophenyl}porphyrinato)oxovanadium(IV)
- Determination of trace element concentrations in ancient rices (red and black rices) and a present-day rice (Koshihikari) : Relationship among the trace element concentrations, species, harvest site and rice parts
- A Highly Potent Insulin-mimetic Zinc(II) Complex with a Zn(S_2O_2) Coordination Mode : Bis(1, 6-dimethyl-3-hydroxy-5-methoxy-2-pentyl-1, 4-dihydropyridine-4-thionato)zinc(II)
- Insulin-Mimetic Vanadyl (IV) Complexes as Evaluated by Both Glucose-Uptake and Inhibition of Free Fatty Acids (FFA) -Release in Isolated Rat Adipocytes
- Chemistry and Biochemistry of Insulin-Mimetic Vanadium and Zinc Complexes. Trial for Treatment of Diabetes Mellitus
- An Extremely High Insulin-Mimetic Activity of Bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridinolato)zinc(II) Complex
- Essential Role of Singlet Oxygen Species in Cytochrome P450-dependent Substrate Oxygenation by Rat Liver Microsomes
- Possible Involvement of Singlet Oxygen Species as Multiple Oxidants in P450 Catalytic Reactions
- Direct Reaction between Shikonin and Thiols Induces Apoptosis in HL60 Cells
- A zinc(II)-glycine complex is an effective inducer of metallothionein and removes oxidative stress
- A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative properties
- Dysfunction of dermal fibroblasts induced by advanced glycation end-products (AGEs) and the contribution of a nonspecific interaction with cell membrane and AGEs
- POSSIBLE ROLES OF ADVANCED GLYCATION END-PRODUCTS IN PROMOTING SKIN AGING
- Protective Effects of Baicalein against Cell Damage by Reactive Oxygen Species
- Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes
- Structure-Activity Relationship of Insulinomimetic Activity of Zinc(II) Complexes with Pyridine-2-sulfonic Acid Derivatives
- In Vitro Alpha-glucosidase Inhibitory Effect of Zn (II) Complex with 6-Methyl-2-picolinmethylamide
- Anti-diabetes Effect of Zn (II)/Carnitine Complex by Oral Administration (Communications to the Editor)
- Differential Reactivity of Metallothionein Isoforms I and II on Active Oxygen Species
- Antioxidative Compounds in the Extracts of Black Rice Brans
- Syntheses, Structures, and Insulin-like Activities of Oxovanadium (IV) Complexes with Tetra-and Penta-dentate Histidine Derivatives
- Analyses of the Metallothioneins and Trace Metals in the Liver and Serum of the Patients with Hepatocellular Carcinoma
- Effects of X-ray Irradiation on Genomic DNA Methylation Levels in Mouse Tissues
- New Insulin-Mimetic Zinc(II)Complexes;Bis-maltolato Zinc(II)and Bis-2-hydroxypyridine-N-oxido Zinc(II)with Zn(O_4)Coordination Mode
- Syntheses, Structures, and Insulin-like Activities of Two Vanadyl Complexes;[VO(GeG)(H_2O)]and[VO(MeM)(H_2O)]
- Inhibitory Effects of Alpinia speciosa K. SCHUM on the Porphyrin Photooxidative Reaction
- Local Detection of Aluminum in Livers of Rats Treated with Aluminum-maltolate Complex
- Protective activity of hamamelitannin on cell damage of murine skin fibroblasts induced by UVB irradiation
- Comparative study of insulin-mimetic activity of vanadium and zinc complexes
- Increased generation of hydrogen peroxide possibly from mitochondrial respiratory chain after UVB irradiation of murine fibroblasts
- Superoxide Anion Scavenging Activity and Metal Contents of Coffee
- Aluminum Distribution in Organs of Animals treated with Aluminum Ion and Its Complex
- Suppressive effects of zinc compounds against UVA-induced reactive oxygen species (ROS) in the skin of hairless mice
- The physiological effects of the undercurrent water from Mt. Fuji on type 2 diabetic KK-A^y mice
- Protective effect of metallogluconates against UVA-induced cutaneous lesion in HR-1 hairless mice
- Oral Administration of Bis(aspirinato)zinc(II) Complex Ameliorates Hyperglycemia and Metabolic Syndrome-Like Disorders in Spontaneously Diabetic KK-Ay Mice: Structure–Activity Relationship on Zinc–Salicylate Complexes
- Molecular Mechanism for Antidiabetic Activity of [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadium(IV) (VO(tpps)) Complex : Studies on Akt Phosphorylation and GLUT4 Translocation in 3T3-L1 Adipocytes
- Potential Insulinominetic Agents of Zinc(II) Complexes with Picolinamide Derivatives : Preparations of Complexes, in Vitro and in Vivo Studies
- 119 Influence of body weight increment from birth to 3 years of age for body weight indices, serum lipid, and leptin concentrations at 10 and 13 years old
- 136 Basal analysis of tissue-specific glucocorticoid metabolism : Approach from 11 β-hydroxysteroid dehydrogenase type 1 gene promoter analysis
- 134 The effects of diabetic pregnancy on fetal glucocorticoid and glucose metabolism in rats
- 179 DIFFERENT RESPONSIVENESS IN BODY WEIGHT TO 11β-HYDROXYSTEROID DEHYDROGENASE INHIBITION BY GLYCYRRHETINIC ACID IN OBESE AND LEAN ZUCKER RATS
- 177 SEXUAL DIFFERENCES IN THEIR CORRELATION BETWEEN SERUM LEPTIN CONCENTRATIONS AND INDICES OF BODY FAT AND WEIGHT : BODY MASS INDEX, PERCENTAGE OF OVERWEIGHT AND PERCENTAGE OF BODY FAT
- Medicinal Aspects of Vanadium Complexes : Treatment of Diabetes Mellitus in Model Animals
- Specific Binding of Vanadyl Ion (VO^) with Thiolate of the Cysteine-34 Residue in Serum Albumin, Demonstrated by CD Spectroscopy and Kinetic Property
- Evidence for the Improvement of Noninsulin-Dependent Diabetes Mellitus in KKA^y Mice with Daily Oral Administration of Bis(6-methylpicolinato)oxovanadium(IV) Complex
- Inhibitory Effect of Oxovanadium(IV), Copper(II), and Zinc(II) Ions on the Activity of an Alpha-glucosidase from a Saccharomyces sp. (特集1:若手が拓く微量元素研究の最前線)