Effects of X-ray Irradiation on Genomic DNA Methylation Levels in Mouse Tissues
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概要
- 論文の詳細を見る
Effects of ionizing radiation on the level of genomic DNA methylation in liver, brain and spleen of mouse as well as in two kinds of cultured cells were examined by high-performance liquid chromatography. Ten Gy of whole body X-radiation reduced the 5-methyldeoxycytidine contents by about 40% within 8 hours after irradiation in liver. Similar effects were observed at 4 or 7 Gy of X-ray irradiation. However, no such change was detected in brain, spleen and cultured cells. The data indicate that radiation-induced alteration in genomic DNA methylation is not ubiquitous among different tissues and cells.
- 日本放射線影響学会の論文
著者
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Tawa R
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
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Tawa Riichi
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
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Komura Jun-ichiro
Section Of Genome And Radiation Biology Department Of Cell Biology Graduate School Of Medicine Tohok
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Sasaki Masao
Radiation Biology Center Kyoto University
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Ono T
Section Of Genome And Radiation Biology Department Of Cell Biology Graduate School Of Medicine Tohok
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Sakurai Hiromu
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
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Sakurai H
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Kurishita Akihiro
Procter &gambler Far East Inc.
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KIMURA.3 YUTAKA
Section of Genome and Radiation Biology, Department of Cell Biology, Graduate School of Medicine, To
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MIYAMURA.4 YOSHINORI
Section of Genome and Radiation Biology, Department of Cell Biology, Graduate School of Medicine, To
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ONO TETSUYA
Section of Genome and Radiation Biology, Department of Cell Biology, Graduate School of Medicine, To
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Miyamura.4 Yoshinori
Section Of Genome And Radiation Biology Department Of Cell Biology Graduate School Of Medicine Tohok
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Sasaki Masao
Radiat. Biol. Center Kyoto Univ.
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Kimura Y
Section Of Genome And Radiation Biology Department Of Cell Biology Graduate School Of Medicine Tohok
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Kimura Yutaka
Section of Genome and Radiation Biology, Department of Cell Biology, Graduate School of Medicine, Tohoku University,
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MIYAMURA YOSHINORI
Section of Genome and Radiation Biology, Department of Cell Biology, Graduate School of Medicine, Tohoku University,
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