Anti-diabetes Effect of Zn (II)/Carnitine Complex by Oral Administration (Communications to the Editor)
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概要
- 論文の詳細を見る
A novel bis(L-carnitinato)Zn(II) complex, Zn(car)_2Cl_2, was prepared, and its insulinomimetic and antidiabetic activities were examined. The complex showed a tendency to lower the high blood glucose levels of KK-A^y mice with type 2 diabetes mellitus when given by oral administration at a dose of 20 mg Zn/kg body weight for 16 d. In addition, the complex improved glucose tolerance ability when examined by the oral glucose tolerance test (1g glucose/kg body weight).
- 公益社団法人日本薬学会の論文
- 2003-02-01
著者
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SAKURAI Hiromu
Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
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YOSHIKAWA Yutaka
Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
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KOJIMA Yoshitane
Department of Chemistry, Graduate School of Science, Osaka City University
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Ueda Eriko
Department of Chemistry, Graduate School of Science, Osaka City University
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Ueda Eriko
Department Of Chemistry Graduate School Of Science Osaka City University
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Sakurai Hiromu
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
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Sakurai H
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Kojima Y
Department Of Chemistry Graduate School Of Science Osaka City University
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Kojima Yoshitane
Department Of Chemistry Faculty Of Science Osaka City University
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Yoshikawa Yutaka
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
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Ueda Eriko
Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University
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