Conformation and coordination behavior of zinc(II) complex with cyclo(L-methionyl-L-histidyl).
スポンサーリンク
概要
- 論文の詳細を見る
The crystal structure of a zinc(II) complex with cyclo(L-methionyl-L-histidyl) shows that all four ligands coordinated tetrahedrally to a Zn<SUP>2+</SUP> ion have a folded conformation, with the imidazole ring facing the piperazine ring in each ligand. The calculation from α-β coupling constant data (obtained by <SUP>1</SUP>H NMR measurement) of the histidyl residue of cyclo(L-methionyl-L-histidyl) linked to a Zn<SUP>2+</SUP> ion shows that the ratio of a folded conformation to an unfolded one is 61:39 in D<SUB>2</SUB>O.
- 公益社団法人 日本化学会の論文
著者
-
Hirotsu Ken
Department Of Chemistry Faculty Of Science Osaka City University
-
Kojima Yoshitane
Department Of Chemistry Faculty Of Science Osaka City University
-
Yamashita Tetsushi
Department Of Chemistry Faculty Of Science Osaka City University
-
Miwa Toshio
Department of Chemistry, Faculty of Science, Osaka City University
関連論文
- Stereochemistry of the Transamination Reaction Catalyzed by Aminodeoxychorismate Lyase from Escherichia coli: Close Relationship between Fold Type and Stereochemistry
- Three-Dimensional Structure of 4-Amino-4-Deoxychorismate Lyase from Escherichia coli
- Selenoprotein Biosynthesis and Selenium-Specific Enzymes (特集1:若手が拓く微量元素研究の最前線)
- A New Family of NAD(P)H-Dependent Oxidoreductases Distinct from Conventional Rossmann-Fold Proteins
- Antidiabetic Activity of Zn(II) Complexes with a Derivative of L-Glutamine
- Insulinomimetic Zinc(II) Complexes with Natural Products: In Vitro Evaluation and Blood Glucose Lowering Effect in KK-A^y Mice with Type 2 Diabetes Mellitus
- Syntheses and Structures of Novel Optically Active Dinuclear Copper (II) Complexes of Structurally Reinforced Macrocyclic Polymines
- Syntheses of Novel Structurally Constrained (S)-Histidyl-(S)-Histidine Derivatives and Their Copper (II) Complexes
- Preparations and Characterizations of Novel N, N'-Ethylene-Bridged-(S)-Histidyl-(S)-Tyrosine Derivatives and Their Copper(II) Complexes as Models of Galactose Oxidase
- Superoxide Dismutase Mimetic Complex of Mn (II)/N, N-Bis (2 - Pyridylmethyl) - (S) - Histidine
- New Zinc (II) Complexes with Tetradentate Amino Acid Derivatives: Structure Characterization, Solution Chemistry, and in vitro Insulinomimetic Activity
- New Insulinomimetic Zinc(II)Complexes of α-Amino Acids and Their Derivatives with Zn(N_2O_2)Coordination Mode
- Merallokinetic Study of Zinc in the Blood of Normal Rats Given Insulinomimetic Zinc(II) Complexes and Improvement of Diabetes Mellitus in Type 2 Diabetic GK Rats by their Oral Administration
- Structure-Activity Relationships of Dermorphin Analogues Containing Chiral Piperazin-2-one and Piperazine Derivatives
- Substrate Recognition Mechanism of Thermophilic Dual-Substrate Enzyme^1
- Three-Dimensional Structure of Rat-Liver Acyl-CoA Oxidase in Complex with a Fatty Acid : Insights into Substrate-Recognition and Reactivity toward Molecular Oxygen
- Structure of the Transition State Analog of Medium-Chain Acyl-CoA Dehydrogenase. Crystallographic and Molecular Orbital Studies on the Charge-Transfer Complex of Medium-Chain Acyl-CoA Dehydrogenase with 3-Thiaoctanoyl-CoA
- Three-Dimensional Structure of the Flavoenzyme Acyl-CoA Oxidase-II from Rat Liver, the Peroxisomal Counterpart of Mitochondrial Acy1-CoA Dehydrogenase
- Synthesis, Structure, and In Vitro and In Vivo Insulinomimetic Activities of the Zinc(II)-6-Ethylpicolinate Complex
- New Bioactive Zinc(II) Complexes with Peptides and Their Derivatives : Synthesis, Structure, and In Vitro Insulinomimetic Activity
- Structure of Imidazole Glycerol Phosphate Synthase from Thermus thermophilus HB8 : Open-Closed Conformational Change and Ammonia Tunneling
- Synthesis and Properties of Some Sterically Protected 2-(1- and 2-Azulenyl)-1-phosphathenes
- Three-Dimensional Structure of Porcine Kidney D-Amino Acid Oxidase at 3.0 Å Resolution
- Crystallization of Expressed Porcine Kidney D-Amino Acid Oxidase and Preliminary X-Ray Crystallographic Characterization
- Engineering the Substrate Specificity of Porcine Kidney D-Amino Acid Oxidase by Mutagenesis of the "Active-Site Lid"
- Glutamine : phenylpyruvate Aminotransferase from an Extremely Thermophilic Bacterium, Thermus thermophilus HB8
- Effects of Hydrogen Bonds in Association with Flavin and Substrate in Flavoenzyme D-Amino Acid Oxidase. The Catalytic and Structural Roles of Gly313 and Thr317
- Zinc(II) complexes with allixin-derivatives as oral therapeutics for type 2 diabetes
- An Extremely High Insulin-Mimetic Activity of Bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridinolato)zinc(II) Complex
- Europium(III)-N, N'-Ethylenebis(L-amino acid) Complexes as New Chiral NMR Lanthanide Shift Reagents for Unprotected α-Amino Acids in Neutral Aqueous Solution
- Three-Dimensional Structure of the Purple Intermediate of Porcine Kidney D-Amino Acid Oxidase. Optimization of the Oxidative Half-Reaction through Alignment of the Product with Reduced Flavin1
- Structural and Mechanistic Studies on D-Amino Acid Oxidase・Substrate Complex: Implications of the Crystal Structure of Enzyme・Substrate Analog Complex
- Structure-Activity Relationship of Insulinomimetic Activity of Zinc(II) Complexes with Pyridine-2-sulfonic Acid Derivatives
- In Vitro Alpha-glucosidase Inhibitory Effect of Zn (II) Complex with 6-Methyl-2-picolinmethylamide
- Anti-diabetes Effect of Zn (II)/Carnitine Complex by Oral Administration (Communications to the Editor)
- Synthesis and Opiate Activity of Pseudo-Tetrapeptides Containing Chiral Piperazin-2-one and Piperazine Derivatives
- Syntheses, Structures, and Insulin-like Activities of Oxovanadium (IV) Complexes with Tetra-and Penta-dentate Histidine Derivatives
- Three-Dimensional Structure of Escherichia coli Branched-Chain Amino Acid Aminotransferase at 2.5 A Resolution^1
- New Insulin-Mimetic Zinc(II)Complexes;Bis-maltolato Zinc(II)and Bis-2-hydroxypyridine-N-oxido Zinc(II)with Zn(O_4)Coordination Mode
- Syntheses, Structures, and Insulin-like Activities of Two Vanadyl Complexes;[VO(GeG)(H_2O)]and[VO(MeM)(H_2O)]
- New Chiral NMR Shift Reagent for α-Amino Acids and N-Protected Oligopeptides in Aqueous Solution
- Syntheses of Silver(I) Complexes with N,N'-Ethylene-Bridged-(S)-Histidyl-(S)-Histidine and -(S)-Methionyl-(S)-Methionine Derivatives
- Microcryoscopy of Water Employing Silver Iodide to Break Supercooling
- Structure of Cyclic Hexa-Pseudopeptide Constructed from N, N'-Ethylene-Bridged-(S)-Alanyl-(S)-Alanine and Glycine
- Binuclear Silver (I) Complex with Double Armed Diaza-Crown Ether Containing Short Metal-Metal Separation
- Potential Insulinominetic Agents of Zinc(II) Complexes with Picolinamide Derivatives : Preparations of Complexes, in Vitro and in Vivo Studies
- Comparative studies of 2-,3-,and 4-pyridylpalladium(II) complexes : Synthesis and properties.
- The Crystal and Molecular Structure of Pyromellitic Acid Dihydrate (Benzene-1,2,4,5-tetracarboxylic Acid Dihydrate)
- The Crystal Structure of Quinolinic Acid
- Asymmetric reactions. III. The asymmetric synthesis of methyl 2-phenylpropionate in the presence of chiral polymers.
- Crystal Structures of 1-(2-Thiazolylazo)-6-bromo-2-naphthol and Bis(1-(2-thiazolylazo)-2-naphthol)iron(II)
- Conformation and coordination behavior of zinc(II) complex with cyclo(L-methionyl-L-histidyl).
- The crystal and molecular structure of the aquabis(cyclo-L-histidyl-L-histidylato)dicopper(II) perchlorate hydrate [H2O Cu2(C12H13N6O2)2](ClO4)2 3.5H2O.
- The Crystal Structure of Dipicolinic Acid Monohydrate
- The Crystal Structure of Cinchomeronic Acid
- The Crystal and Molecular Structure of Nagilactone A Diacetate
- The enantioface-differentiating methylation of the N-benzylidene-DL-phenylalanine methyl ester in the presence of chiral lithium amides.
- Asymmetric reactions. IV. Asymmetric, catalytic activity of poly(2-quinuclidinylmethyl acrylate).
- Asymmetric, partial acetylation of dl-1-phenylethanol by means of chiral polymers.
- Asymmetric reactions. II. Asymmetric synthesis of methyl .ALPHA.-phenylpropionate by means of chiral polymers.
- Preparations and structures of silver(I) complexes with cyclo(glcyl-L-histidyl), cyclo(L-methionyl-L-histidyl), and cyclo(L-histidyl-L-histidyl).
- Stability constants of complex formations between divalent metal ions and cyclic dipeptides: Cyclo(glycyl-L-histidyl) and cyclo(L-methionyl-L-histidyl).
- The Synthesis and Asymmetric Adsorption of an Optically-active Basic Polymer Starting from L-Proline
- X-Ray Study of the Compound Obtained by the Reaction of Nδ-Salicylidene-L-ornithine and Palladium(II) acetate. The Crystal Structure of (Nα-Salicylidene-D-ornithinato) (Nα-Salicylidene-L-ornithinato)di
- Acetylation of 2-C-benzyl-L-lyxo-3-hexulosono-1,4-lactone.
- Structural studies of cyclo(L-histidyl-L-histidyl) and its metal complexes.
- Overproduction and preliminary X-ray characterization of aspartate aminotransferase from Escherichia coli.
- Substrate Recognition Mechanism of Thermophilic Dual-Substrate Enzyme.
- Three-Dimensional Structure of 4-Amino-4-Deoxychorismate Lyase from Escherichia coli.