New Insulin-Mimetic Zinc(II)Complexes;Bis-maltolato Zinc(II)and Bis-2-hydroxypyridine-N-oxido Zinc(II)with Zn(O_4)Coordination Mode

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概要

• 論文の詳細を見る
• 2000-08-05

著者

• YOSHIKAWA Yutaka

  Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University

• KOJIMA Yoshitane

  Department of Chemistry, Graduate School of Science, Osaka City University

• MIYAKE Hiroyuki

  Department of Chemistry, Faculty of Science, Osaka City University

• Kawabe Kenji

  Department Of Chemistry Graduate School Of Science Osaka City University

• Ueda Eriko

  Department Of Chemistry Graduate School Of Science Osaka City University

• Sakurai Hiromu

  Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University

• Kojima Y

  Department Of Chemistry Graduate School Of Science Osaka City University

• Kojima Yoshitane

  Department Of Chemistry Faculty Of Science Osaka City University

• Kumekawa Katsumi

  Department Of Biosciences Teikyo University

• Kawabe Kenji

  Department Of Chemistry Faculty Of Science Osaka City University

• Miyake Hiroyuki

  Department Of Chemistry Graduate School Of Science Osaka City University

• Yoshikawa Yutaka

  Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University

• Miyake Hiroyuki

  Department Of Chemistry Faculty Of Science Osaka City University

• Kawabe Kenji

  Department of Biosciences, Teikyo University

• Ueda Eriko

  Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University

関連論文

• Mononuclear to Tetranuclear Structural Transformation in Vanadyl Complexes of 3-Hydroxypyridine-2-carboxylic Acid (H_2hpic)
• Breaks in Double-Strand DNA by Cu(II) Complexes of Etoposide (VP-16) and Its Derivatives, as Evaluated by S1 Nuclease Treatment
• Evaluation of Distribution Patterns for Copper and Zinc in Metallothionein and Superoxide Dismutase in Chronic Liver Diseases and Hepatocellular Carcinoma Using High-Performance Liquid Chromatography(HPLC)(Analytical Biochemistry)
• Antidiabetic Activity of Zn(II) Complexes with a Derivative of L-Glutamine
• Insulinomimetic Zinc(II) Complexes with Natural Products: In Vitro Evaluation and Blood Glucose Lowering Effect in KK-A^y Mice with Type 2 Diabetes Mellitus
• Syntheses and Structures of Novel Optically Active Dinuclear Copper (II) Complexes of Structurally Reinforced Macrocyclic Polymines
• Syntheses of Novel Structurally Constrained (S)-Histidyl-(S)-Histidine Derivatives and Their Copper (II) Complexes
• Catalytic and Spectroscopic Properties of Imidazole(N)-Fe(III)porphyrin Complexes in Dioxygenation of Tryptophan Derivatives
• Preparations and Characterizations of Novel N, N'-Ethylene-Bridged-(S)-Histidyl-(S)-Tyrosine Derivatives and Their Copper(II) Complexes as Models of Galactose Oxidase
• Superoxide Dismutase Mimetic Complex of Mn (II)/N, N-Bis (2 - Pyridylmethyl) - (S) - Histidine
• Scavenging Activities of α-, β- and γ-Thujaplicins against Active Oxygen Species
• New Zinc (II) Complexes with Tetradentate Amino Acid Derivatives: Structure Characterization, Solution Chemistry, and in vitro Insulinomimetic Activity
• New Insulinomimetic Zinc(II)Complexes of α-Amino Acids and Their Derivatives with Zn(N_2O_2)Coordination Mode
• Selenium Supplementation Rescues Cardiac Output in Patients with Severe Heart Failure who are Intractable to ACE Inhibitors and β-Blockers(Heart Failure, Clinical 14 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Preventive Effects of Zn(II) Complex with Papaya Powder on Type 2 Diabetes Mellitus
• A New Physiologically Based Pharmacokinetic Analysis for In Vivo Organ Disposition of Nitroxyl Spin Probes in Mice as Measured by Multisite Detection L-band ESR (MSD-LESR)
• Role of oxidative stress on pathogenesis of hypertensive cerebrovascular lesions
• Relationship betweeen X- or L-Band ESR Spectra and Coordination Structures of Copper(II) Complexes with a CuO_4 Coordination Mode
• Coordination-Dependent ESR Spectra of Copper(II) Complexes with a CuN_4 Type Cooridnation Mode : Relationship between ESR Parameters and Stability Constants or Redox Potentials of the Complexes
• Oxovanadium(IV)-Porphyrin Complex as a Potent Insulin-Mimetic. Treatment of Experimental Type 1 Diabetic Mice by the Complex [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadate(IV)(4-)
• BCSJ Award Article: Oxovanadium(IV)-Porphyrin Complex as a Potent Insulin-Mimetic. Treatment of Experimental Type 1 Diabetic Mice by the Complex [meso-Tetrakis(4-sulfonatopbenyl)porphyrinato]oxovanadate(IV)(4-)
• Merallokinetic Study of Zinc in the Blood of Normal Rats Given Insulinomimetic Zinc(II) Complexes and Improvement of Diabetes Mellitus in Type 2 Diabetic GK Rats by their Oral Administration
• Lysophosphatidylcholine Enhances Superoxide Anions Production via Endothelial NADH/NADPH Oxidase
• A Chemical Model of Tryptophan 2,3-Dioxygenase : Reactivity and Formation of a Reactive Intermediate in the Dioxygenation Processes
• A New Determination Method of Nitric Oxide (NO) with a NO-selective Electrode Demonstrated by the Kinetic Analysis of NO Generation and Decomposition
• Structure-Activity Relationships of Dermorphin Analogues Containing Chiral Piperazin-2-one and Piperazine Derivatives
• Antioxidative Properties of Extracts from Ancient Rice Brans
• Novel screening method for ultraviolet protection : Combination of a human skin-equivalent model and 8-hydroxy-2'-deoxyguanosine
• Chemical Structure-Dependent Differential Effects of Flavonoids on the Catalase Activity as Evaluated by a Chemiluminescent Method(Analytical Biochemistry)
• An Improved Diagnostic Method for Chronic Hepatic Disorder : Analyses of Metallothionein Isoforms and Trace Metals in the Liver of Patients with Hepatocellular Carcinoma as Determined by Capillary Zone Electrophoresis and Inductively Coupled Plasma-Mass S
• A New Diagnostic Method for Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma Based on Serum Metallothionein,Copper, and Zinc Levels
• Synthesis, Structure, and In Vitro and In Vivo Insulinomimetic Activities of the Zinc(II)-6-Ethylpicolinate Complex
• New Bioactive Zinc(II) Complexes with Peptides and Their Derivatives : Synthesis, Structure, and In Vitro Insulinomimetic Activity
• New Insulinomimetic Zinc(II) Complexes of Nicotinamide and its Derivatives: X-ray Structure and Biochemical Activity
• A New Type of Orally Active Insulin-Mimetic Vanadyl Complex: Bis(l-oxy-2-pyridinethiolato)oxovanalum(IV)with VO(S_2O_2) Coordination Mode
• Evidence for Singlet Oxygen Involvement in Rat and Human Cytochrome P450-dependent Substrate Oxidations
• Oxovanadium (IV) and (V) Complexes with 3-Hydroxy-4(1H)-pyridinones and 1-Hydroxy-2(1H)-pyrimidinones - Synthesis, Structural Characteristics, and Their Insulin-mimetic Activities
• Insulinomimetic Vanadyl-Hydroxythiazolethione Complexes with VO(S_2O_2) Coordination Mode : The Correlation between the Activity and Hammett's Substituent Constant
• Synthesis of New Vanadyl Complexes of Hydroxyazine-type Heterocycles and Their Insulin-Mimetic Activities
• Zinc(II) complexes with allixin-derivatives as oral therapeutics for type 2 diabetes
• Zinc(II) complexes with allixin-derivatives as oral therapeutics for type 2 diabetes (特集:糖尿病と金属)
• Insulinomimetic Activity of Vanadyl-Porphyrin Complexes
• A New Anti-diabetic Zn(II)-Hinokitiol (β-Thujaplicin) Complex with Zn(O_4) Coordination Mode
• A New Type of Orally Active Insulin-mimetic Vanadyl-porphyrin Complex : meso-Tetrakis({4-sulfonatophenyl}porphyrinato)oxovanadium(IV)
• Determination of trace element concentrations in ancient rices (red and black rices) and a present-day rice (Koshihikari) : Relationship among the trace element concentrations, species, harvest site and rice parts
• A Highly Potent Insulin-mimetic Zinc(II) Complex with a Zn(S_2O_2) Coordination Mode : Bis(1, 6-dimethyl-3-hydroxy-5-methoxy-2-pentyl-1, 4-dihydropyridine-4-thionato)zinc(II)
• Insulin-Mimetic Vanadyl (IV) Complexes as Evaluated by Both Glucose-Uptake and Inhibition of Free Fatty Acids (FFA) -Release in Isolated Rat Adipocytes
• Chemistry and Biochemistry of Insulin-Mimetic Vanadium and Zinc Complexes. Trial for Treatment of Diabetes Mellitus
• An Extremely High Insulin-Mimetic Activity of Bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridinolato)zinc(II) Complex
• Essential Role of Singlet Oxygen Species in Cytochrome P450-dependent Substrate Oxygenation by Rat Liver Microsomes
• Possible Involvement of Singlet Oxygen Species as Multiple Oxidants in P450 Catalytic Reactions
• Direct Reaction between Shikonin and Thiols Induces Apoptosis in HL60 Cells
• A zinc(II)-glycine complex is an effective inducer of metallothionein and removes oxidative stress
• A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative properties
• Dysfunction of dermal fibroblasts induced by advanced glycation end-products (AGEs) and the contribution of a nonspecific interaction with cell membrane and AGEs
• POSSIBLE ROLES OF ADVANCED GLYCATION END-PRODUCTS IN PROMOTING SKIN AGING
• Protective Effects of Baicalein against Cell Damage by Reactive Oxygen Species
• Europium(III)-N, N'-Ethylenebis(L-amino acid) Complexes as New Chiral NMR Lanthanide Shift Reagents for Unprotected α-Amino Acids in Neutral Aqueous Solution
• Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes
• Structure-Activity Relationship of Insulinomimetic Activity of Zinc(II) Complexes with Pyridine-2-sulfonic Acid Derivatives
• In Vitro Alpha-glucosidase Inhibitory Effect of Zn (II) Complex with 6-Methyl-2-picolinmethylamide
• Anti-diabetes Effect of Zn (II)/Carnitine Complex by Oral Administration (Communications to the Editor)
• Differential Reactivity of Metallothionein Isoforms I and II on Active Oxygen Species
• Antioxidative Compounds in the Extracts of Black Rice Brans
• Syntheses, Structures, and Insulin-like Activities of Oxovanadium (IV) Complexes with Tetra-and Penta-dentate Histidine Derivatives
• Seven-coordinate Rhenium(III) Complexes with a Labile Coordination Site Assembled on Indium-doped Tin Oxide (ITO) Electrodes : Catalytic Reduction of Dioxygen to Hydrogen Peroxide
• Analyses of the Metallothioneins and Trace Metals in the Liver and Serum of the Patients with Hepatocellular Carcinoma
• Effects of X-ray Irradiation on Genomic DNA Methylation Levels in Mouse Tissues
• New Insulin-Mimetic Zinc(II)Complexes;Bis-maltolato Zinc(II)and Bis-2-hydroxypyridine-N-oxido Zinc(II)with Zn(O_4)Coordination Mode
• Syntheses, Structures, and Insulin-like Activities of Two Vanadyl Complexes;[VO(GeG)(H_2O)]and[VO(MeM)(H_2O)]
• Inhibitory Effects of Alpinia speciosa K. SCHUM on the Porphyrin Photooxidative Reaction
• Local Detection of Aluminum in Livers of Rats Treated with Aluminum-maltolate Complex
• Protective activity of hamamelitannin on cell damage of murine skin fibroblasts induced by UVB irradiation
• Effects of Dissipation on Quantum Phase Slippage in Charge Density Wave Systems
• Comparative study of insulin-mimetic activity of vanadium and zinc complexes
• Increased generation of hydrogen peroxide possibly from mitochondrial respiratory chain after UVB irradiation of murine fibroblasts
• Superoxide Anion Scavenging Activity and Metal Contents of Coffee
• Aluminum Distribution in Organs of Animals treated with Aluminum Ion and Its Complex
• Suppressive effects of zinc compounds against UVA-induced reactive oxygen species (ROS) in the skin of hairless mice
• Cellular Mechanism of Zinc-Hinokitiol Complexes in Diabetes Mellitus
• The physiological effects of the undercurrent water from Mt. Fuji on type 2 diabetic KK-A^y mice
• New Chiral NMR Shift Reagent for α-Amino Acids and N-Protected Oligopeptides in Aqueous Solution
• Syntheses of Silver(I) Complexes with N,N'-Ethylene-Bridged-(S)-Histidyl-(S)-Histidine and -(S)-Methionyl-(S)-Methionine Derivatives
• Microcryoscopy of Water Employing Silver Iodide to Break Supercooling
• Structure of Cyclic Hexa-Pseudopeptide Constructed from N, N'-Ethylene-Bridged-(S)-Alanyl-(S)-Alanine and Glycine
• Protective effect of metallogluconates against UVA-induced cutaneous lesion in HR-1 hairless mice
• Oral Administration of Bis(aspirinato)zinc(II) Complex Ameliorates Hyperglycemia and Metabolic Syndrome-Like Disorders in Spontaneously Diabetic KK-Ay Mice: Structure–Activity Relationship on Zinc–Salicylate Complexes
• Molecular Mechanism for Antidiabetic Activity of [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadium(IV) (VO(tpps)) Complex : Studies on Akt Phosphorylation and GLUT4 Translocation in 3T3-L1 Adipocytes
• Potential Insulinominetic Agents of Zinc(II) Complexes with Picolinamide Derivatives : Preparations of Complexes, in Vitro and in Vivo Studies
• Medicinal Aspects of Vanadium Complexes : Treatment of Diabetes Mellitus in Model Animals
• Specific Binding of Vanadyl Ion (VO^) with Thiolate of the Cysteine-34 Residue in Serum Albumin, Demonstrated by CD Spectroscopy and Kinetic Property
• Evidence for the Improvement of Noninsulin-Dependent Diabetes Mellitus in KKA^y Mice with Daily Oral Administration of Bis(6-methylpicolinato)oxovanadium(IV) Complex
• In Vitro Study on the Transport of Zinc across Intestinal Epithelial Cells Using Caco-2 Monolayers and Isolated Rat Intestinal Membranes
• Inhibitory Effect of Oxovanadium(IV), Copper(II), and Zinc(II) Ions on the Activity of an Alpha-glucosidase from a Saccharomyces sp. (特集1:若手が拓く微量元素研究の最前線)
• Conformation and coordination behavior of zinc(II) complex with cyclo(L-methionyl-L-histidyl).
• The crystal and molecular structure of the aquabis(cyclo-L-histidyl-L-histidylato)dicopper(II) perchlorate hydrate [H2O Cu2(C12H13N6O2)2](ClO4)2 3.5H2O.
• Preparations and structures of silver(I) complexes with cyclo(glcyl-L-histidyl), cyclo(L-methionyl-L-histidyl), and cyclo(L-histidyl-L-histidyl).
• Stability constants of complex formations between divalent metal ions and cyclic dipeptides: Cyclo(glycyl-L-histidyl) and cyclo(L-methionyl-L-histidyl).
• X-Ray Study of the Compound Obtained by the Reaction of Nδ-Salicylidene-L-ornithine and Palladium(II) acetate. The Crystal Structure of (Nα-Salicylidene-D-ornithinato) (Nα-Salicylidene-L-ornithinato)di
• Structural studies of cyclo(L-histidyl-L-histidyl) and its metal complexes.

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