Potential Insulinominetic Agents of Zinc(II) Complexes with Picolinamide Derivatives : Preparations of Complexes, in Vitro and in Vivo Studies
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概要
- 論文の詳細を見る
Following the finding of in vitro insulinominetic activities of new prepared Zn(II) complexes with amide ligands (2-picolinamide (pa-a) and 6-methyl-2-picolinmethylamide (6mpa-ma)) in isolated rat adipocytes treated with epinephrine in terms of inhibition of free fatty acid release, their blood glucose normalizing effects were observed on daily intraperitoneal injections for 14d in a type 2 diabetes mellitus model animal, KK-A^y mice. The blood glucose levels of KK-A^y mice were maintained in a normal range during the administration of both complexes. After the administration of each complex for 14d, the improvement of glucose metabolism was confirmed as judged by the glucose tolerance test.
- 公益社団法人日本薬学会の論文
- 2002-03-01
著者
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KOJIMA Yoshitane
Department of Chemistry, Graduate School of Science, Osaka City University
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Ueda Eriko
Department Of Chemistry Graduate School Of Science Osaka City University
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Sakurai Hiromu
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
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Kojima Y
Department Of Chemistry Graduate School Of Science Osaka City University
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Kojima Yoshitane
Department Of Chemistry Faculty Of Science Osaka City University
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Yoshikawa Yutaka
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
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ISHINO Yoshio
Department of Organic Chemistry, Osaka Municipal Technical Research Institute
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Ishino Yoshio
Department Of Organic Chemistry Osaka Municipal Technical Research Institute
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Ueda Eriko
Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University
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Ishino Yoshio
Department of Chemistry, Faculty of Science, Osaka City University
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