Breaks in Double-Strand DNA by Cu(II) Complexes of Etoposide (VP-16) and Its Derivatives, as Evaluated by S1 Nuclease Treatment
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概要
- 論文の詳細を見る
Single-strand breaks (ssb) in double-strand (ds) DNA produced by hydroxyl radicals (・OH) generated by Cu(II) complexes of podophyllotoxin (PD)-related compounds were evaluated using S1 nuclease digestion. Cu(II) complexes of VP-16 (etoposide, 4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidene-β-D-glucopyranoside)), 4'-demethylepi-PD (DEPD), and syringic acid (SA) exhibited both ssb and ds breaks (dsb) in ColE1-HaeII and pBR322-BglI DNA fragments, in which the number of ssb was found to be more than three times and four times greater than that of dsb, respectively. Cytosine (C)methylation of cytosine-guanine doublet (CpG) in pBR322-BglI DNA inhibited both ssb and dsb within DNA segments by ・OH generated by the Cu(II) complexes.
- 社団法人日本薬学会の論文
- 1997-09-15
著者
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SAKURAI Hiromu
Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
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Lee Kuo-hsiung
Division Of Medicinal Chemistry And Natural Products School Of Pharmacy University Of North Carolina
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IMAKURA Yasuhiro
Faculty of Sciences, Naruto University of Education
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TAWA Riichi
Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
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TAKAMI Masashi
Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
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Tawa Riichi
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
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Imakura Yasuhiro
Faculty Of Science Naruto University Of Education
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Takami Masashi
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
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Sakurai Hiromu
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
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