Insulinomimetic Zinc(II) Complexes with Natural Products: In Vitro Evaluation and Blood Glucose Lowering Effect in KK-A^y Mice with Type 2 Diabetes Mellitus

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概要

• 論文の詳細を見る

• In vitro insulinomimetic activities of Zn(II) complexes with three natural products, betaine, L-lactic acid, and D-(-)-quinic acid (qui), were found in rat adipocytes treated with epinephrine in terms of the inhibition of free fatty acid release. Based on the results, the blood glucose lowering effect in KK-A^y mice with type 2 diabetes mellitus was observed by daily I.p. injections of a monomeric zinc(II) complex, Zn(qui)_2, for 13 d.

• 公益社団法人日本薬学会の論文
• 2003-08-01

著者

• SAKURAI Hiromu

  Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University

• YAMAMOTO Shinobu

  Showa College of Pharmaceutical Sciences

• Yamamoto Shuhei

  Department Of Chemistry Graduate School Of Science Osaka City University

• 山本 晋

  Faculty Of Pharmaceutical Sciences Osaka University

• YOSHIKAWA Yutaka

  Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University

• KOJIMA Yoshitane

  Department of Chemistry, Graduate School of Science, Osaka City University

• Ueda Eriko

  Department of Chemistry, Graduate School of Science, Osaka City University

• Ueda Rie

  Department of Chemistry, Graduate School of Science, Osaka City University

• Kumekawa Katsumi

  Department of Biosciences, Teikyo University

• Yanagihara Naohisa

  Department of Biosciences, Teikyo University

• Kawabe Kenji

  Department Of Chemistry Graduate School Of Science Osaka City University

• Ueda Rie

  Department Of Chemistry Graduate School Of Science Osaka City University

• Ueda Rie

  Department Of Chemistry Faculty Of Science Nara Women's University

• Ueda Eriko

  Department Of Chemistry Graduate School Of Science Osaka City University

• Sakurai Hiromu

  Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University

• Sakurai H

  Kyoto Pharmaceutical Univ. Kyoto Jpn

• Yamamoto Shozo

  Department Of Biochemistry Tokushima University School Of Medicine

• Kojima Y

  Department Of Chemistry Graduate School Of Science Osaka City University

• Kojima Yoshitane

  Department Of Chemistry Faculty Of Science Osaka City University

• Kumekawa Katsumi

  Department Of Biosciences Teikyo University

• Ueda Rie

  Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University

• Yoshikawa Yutaka

  Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University

• Yanagihara N

  Department Of Biosciences Teikyo University

• Yanagihara Naohisa

  Department Of Biosciences Faculty Of Science And Engineering Teikyo University

• Ueda Eriko

  Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University

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