Distribution and Immune Responses Resulting from Oral Administration of D-Limonene in Rats
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概要
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We investigated the relationship between the absorptive pathway and the immune responses of the lung, particularly the phagocytic function of alveolar macrophages (MO) after oral administration of D-limonene in rats. D-Limonene was orally administered in oily solution with a stomach tube in thoracic duct-cannulated rats, and the lymphatic out-put of D-limonene was measured. D-Limonene levels reached a maximum in thoracic duct lymph and lung 3 h after its oral administration. It also significantly increased in bronchoalveolar lavage fluid (BALF) and alveolar Mφ, in which there was frequently a focal exu-dation of lipid droplets containing D-limonene into the alveolar cavity through alveolar cap-illary walls. Second, D-limonene orally given to rats (250, 500, 1, 000mg/kg/d) for 8 con-secutive days resulted in a marked increase in both the number and the phagocytic activity of alveolar Mφ compared to the controls. BALF from rats dosed with D-limonene (1, 000mg/kg/d) enhanced the phagocytic activity of alveolar Mφ from control rats because the dose was prolonged. The activity of alveolar Mφ following in vitro incubation with D-limonene also increased in a dose-dependent manner. An oral administration of D-limonene enhanced the Con A-stimulated proliferation of splenocytes. These results suggest that D-limonene taken up from the thoracic duct lymph moves to the lung and directly activates the immune response of alveolar Mφ there, or indirectly activates it through activated lymphocytes.
- 財団法人 学会誌刊行センターの論文
- 2002-04-01
著者
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Yamamoto Shuhei
Department Of Chemistry Graduate School Of Science Osaka City University
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Uezu Kayoko
School Of Home Economics Tokushima Bunri University
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Kishino Y
Department Of Nutrition School Of Medicine University Of Tokushima
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Kishino Yasuo
School Of Home Economics Tokushima Bunri University
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Yamamoto Shozo
Department Of Biochemistry Tokushima University School Of Medicine
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Kishino Y
School Of Home Economics Tokushima Bunri University
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Hamada Masafumi
Department Of Nutrition School Of Medicine The University Of Tokushima
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Matsushita Junko
School Of Home Economics Tokushima Bunri University
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Yamamoto S
Department Of Applied Chemistry Graduate School Of Engineering Osaka City University (ocu)
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Yamamoto Shigeru
Department Of Nutrition School Of Medicine The University Of Tokushima
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Yamamoto Shigeru
Department Of Biology Faculty Of Science Kyushu University
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