Difructose Anhydride III Enhances Bioavailability of Water-Insoluble Iron in Anemic Vietnamese Women

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概要

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• Difructose anhydride III (DFAIII) is an indigestible disaccharide and has been shown to enhance iron absorption in animal studies; however, the effect has not been investigated in anemic subjects. We investigated the efficacy of co-administration of DFAIII with water-insoluble iron in the treatment of iron deficiency anemia in Vietnamese women. One hundred sixty-eight moderately anemic women (80 g/L<hemoglobin (Hb)<120 g/L) participated in a double-blinded, placebo-controlled study with daily supplementation of iron for 6 mo. The volunteers were randomly assigned into four groups, i.e., Group A: received 15 mg Fe as ferric pyrophosphate; Group B: received 15 mg Fe as ferric pyrophosphate and 1.25 g DFAIII; Group C: received 15 mg Fe as ferrous sulfate; Group D: received a placebo. Hb and iron status were measured at baseline and after 2, 4 and 6 mo of intervention. The ratio of transferrin receptor to ferritin was used to estimate stored and functional body iron (BI). One hundred sixteen (69.0%) women completed the trial. After 6 mo, mean (±SE) Hb concentration was higher in Group A (121.6±1.7 g/L), Group B (126.4±1.5 g/L) and Group C (126.8±1.6 g/L) compared to Group D (107.0±1.7 g/L, p<0.0001). Mean change in BI was twofold greater in Group B (5.0±0.5 mg/kg) than that in Group A (2.5±0.6 mg/kg, p=0.008). The percentage of anemia was significantly reduced in Group B (18.8%) compared to Group D (95.8%, p<0.0001) and Group A (39.1%, p=0.033). Co-administration of DFAIII enhances Hb concentration and iron stores more than single administration of water-insoluble iron in anemic Vietnamese women.

著者

• UOTSU Nobuo

  FANCL Research Institute, FANCL Corporation

• Nakamori Masayo

  Department of Nutrition and Food Science, Ochanomizu University

• Hien Vu

  National Institute of Nutrition

• Khan Nguyen

  National Institute of Nutrition

• LAM Nguyen

  National Institute of Nutrition

• DUNG Nguyen

  National Institute of Nutrition

• SHIOMI Takuya

  FANCL Research Institute, FANCL Corporation

• OKUHARA Yasuhide

  FANCL Research Institute, FANCL Corporation

• KISE Mitsuo

  FANCL Research Institute, FANCL Corporation

• SHIGEMATSU Norihiro

  FANCL Business Development Headquarters, Preventive Healthcare Division

• YAMAMOTO Shigeru

  Department of Nutrition and Food Science, Ochanomizu University

• Nakamori Masaya

  Department Of Electrical And Information Engineering Kinki University Technical College

• Nakamori Masaya

  Department Of Electrical Engineering Kumano Technical College

• Nakamori Masaya

  徳島大学医学部

• Lam Nguyen

  National Inst. Of Nutrition

• Nakamori Masaya

  Kinki Univ. Technical Coll. Mie Jpn

• Dung Nguyen

  National Inst. Of Nutrition

• Khan Nguyen

  National Inst. Of Nutrition

• Hien Vu

  National Inst. Of Nutrition

• Kise Mitsuo

  Fancl Research Institute Fancl Corporation

• Shiomi Takuya

  Fancl Res. Inst. Fancl Corp.

• Yamamoto Shigeru

  Department Of International Nutrition Institute Of Health Biosciences The University Of Tokushima Gr

• Shigematsu Norihiro

  Fancl Business Dev. Headquarters Preventive Healthcare Div.

• Nakamori Masayo

  Department Of International Public Health Nutrition

• Okuhara Yasuhide

  Fancl Res. Inst. Fancl Corp.

• Uotsu Nobuo

  Fancl Res. Inst. Fancl Corp.

• Yamamoto Shigeru

  Department Of Biology Faculty Of Science Kyushu University

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